L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury

[1]  B. Vissel,et al.  Maternal Cigarette Smoke Exposure Worsens Neurological Outcomes in Adolescent Offspring with Hypoxic-Ischemic Injury , 2017, Front. Mol. Neurosci..

[2]  N. Greig,et al.  Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration , 2017, Scientific Reports.

[3]  K. Anstey,et al.  Anxiety and comorbid depression following traumatic brain injury in a community-based sample of young, middle-aged and older adults. , 2017, Journal of affective disorders.

[4]  C. Pollock,et al.  Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers , 2017, Front. Mol. Neurosci..

[5]  L. Nguyen,et al.  Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterations , 2016, Clinical and experimental pharmacology & physiology.

[6]  C. Pollock,et al.  Impact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring , 2016, Scientific Reports.

[7]  J. Verhaagen,et al.  Evaluation of Five Tests for Sensitivity to Functional Deficits following Cervical or Thoracic Dorsal Column Transection in the Rat , 2016, PloS one.

[8]  R. Gruen,et al.  Pharmacological interventions in traumatic brain injury: Can we rely on systematic reviews for evidence? , 2016, Injury.

[9]  David Tweedie,et al.  Blast traumatic brain injury–induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4 , 2016, Alzheimer's & Dementia.

[10]  Victoria P. A. Johnstone,et al.  Experimental Traumatic Brain Injury Results in Long-Term Recovery of Functional Responsiveness in Sensory Cortex but Persisting Structural Changes and Sensorimotor, Cognitive, and Emotional Deficits. , 2015, Journal of neurotrauma.

[11]  J. Pierce,et al.  Traumatic Brain Injury and Mitochondrial Dysfunction , 2015, The American journal of the medical sciences.

[12]  A. Anwer,et al.  Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking. , 2015, The international journal of biochemistry & cell biology.

[13]  Martin E. Gosnell,et al.  L-Carnitine reverses maternal cigarette smoke exposure-induced renal oxidative stress and mitochondrial dysfunction in mouse offspring. , 2015, American journal of physiology. Renal physiology.

[14]  F. Kobeissy,et al.  Translational Considerations for Behavioral Impairment and Rehabilitation Strategies after Diffuse Traumatic Brain Injury , 2015 .

[15]  Xiaoxi Li,et al.  Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental stroke , 2015, Neurochemistry International.

[16]  R. Vemuganti,et al.  Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries , 2014, Molecular Neurobiology.

[17]  M. Pekny,et al.  Astrocyte reactivity and reactive astrogliosis: costs and benefits. , 2014, Physiological reviews.

[18]  C. Mallard,et al.  Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2 Polarization , 2014, PloS one.

[19]  Xinglong Wang,et al.  Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. , 2014, Biochimica et biophysica acta.

[20]  Ajit S. Divakaruni,et al.  Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark‐Type Oxygen Electrode , 2014, Current protocols in toxicology.

[21]  S. Mitra,et al.  Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. , 2014, Physiological reviews.

[22]  M. Morris,et al.  Maternal obesity impairs brain glucose metabolism and neural response to hyperglycemia in male rat offspring , 2014, Journal of neurochemistry.

[23]  J. DiNicolantonio,et al.  L-carnitine for the treatment of acute myocardial infarction. , 2014, Reviews in cardiovascular medicine.

[24]  M. Kossut,et al.  Functional assessment of sensory functions after photothrombotic stroke in the barrel field of mice , 2014, Behavioural Brain Research.

[25]  V. Yong,et al.  Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury. , 2014, Brain : a journal of neurology.

[26]  S. Saad,et al.  Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents , 2014, Diabetologia.

[27]  A. Atlante,et al.  Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway , 2014, Front. Aging Neurosci..

[28]  E. Yan,et al.  Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor , 2013, Journal of Neuroinflammation.

[29]  K. Byrnes,et al.  Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury , 2013, Journal of Neuroinflammation.

[30]  N. Greig,et al.  Exendin-4 Ameliorates Traumatic Brain Injury-Induced Cognitive Impairment in Rats , 2013, PloS one.

[31]  A. Mustafa,et al.  Pathophysiology of traumatic brain injury. , 2013, Neurosciences.

[32]  Guanghui Wang,et al.  Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance , 2013, Autophagy.

[33]  Kaj Blennow,et al.  Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers , 2013, Nature Reviews Neurology.

[34]  G. Cheng,et al.  Mitochondria in traumatic brain injury and mitochondrial‐targeted multipotential therapeutic strategies , 2012, British journal of pharmacology.

[35]  W. Deng,et al.  Exenatide prevents high-glucose-induced damage of retinal ganglion cells through a mitochondrial mechanism , 2012, Neurochemistry International.

[36]  Rui Zhang,et al.  Neuroprotective Effects of Pre-Treament with l-Carnitine and Acetyl-l-Carnitine on Ischemic Injury In Vivo and In Vitro , 2012, International journal of molecular sciences.

[37]  M. Antunes,et al.  The novel object recognition memory: neurobiology, test procedure, and its modifications , 2011, Cognitive Processing.

[38]  T. Librowski,et al.  L-carnitine--metabolic functions and meaning in humans life. , 2011, Current drug metabolism.

[39]  N. Hattori,et al.  Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[40]  G. Fiskum,et al.  Neuroprotection by Acetyl-L-Carnitine after Traumatic Injury to the Immature Rat Brain , 2011, Developmental Neuroscience.

[41]  J. Oliveira.  Nature and cause of mitochondrial dysfunction in Huntington’s disease: focusing on huntingtin and the striatum , 2010, Journal of neurochemistry.

[42]  T. Maher,et al.  Acetyl‐l‐carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats , 2010, Annals of the New York Academy of Sciences.

[43]  Guy C. Brown,et al.  Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons , 2010, Molecular Neurobiology.

[44]  Chang-kai Sun,et al.  Implications of astrocytes in neurovascular coupling , 2010 .

[45]  M. Sofroniew,et al.  Astrocytes: biology and pathology , 2009, Acta Neuropathologica.

[46]  Ian Q. Whishaw,et al.  The Ladder Rung Walking Task: A Scoring System and its Practical Application. , 2009, Journal of visualized experiments : JoVE.

[47]  L. Rönnbäck,et al.  Mental fatigue and impaired information processing after mild and moderate traumatic brain injury , 2009, Brain injury.

[48]  S. Scheff,et al.  Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. , 2008, Free radical biology & medicine.

[49]  B. Stoica,et al.  Roscovitine Reduces Neuronal Loss, Glial Activation, and Neurologic Deficits after Brain Trauma , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[50]  B. MacVicar,et al.  Astrocyte control of the cerebrovasculature , 2007, Glia.

[51]  C. McMurray,et al.  Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases , 2007, Neuroscience.

[52]  A. Walf,et al.  The use of the elevated plus maze as an assay of anxiety-related behavior in rodents , 2007, Nature Protocols.

[53]  A. Young,et al.  Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures , 2006, International Journal of Obesity.

[54]  D. Arciniegas,et al.  Mild traumatic brain injury: a neuropsychiatric approach to diagnosis, evaluation, and treatment , 2005, Neuropsychiatric disease and treatment.

[55]  P. Renshaw,et al.  Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research , 2005, Molecular Psychiatry.

[56]  A. Rahbar,et al.  Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus , 2005, European Journal of Clinical Nutrition.

[57]  A. Nitta,et al.  Involvement of glial cell line‐derived neurotrophic factor in activation processes of rodent macrophages , 2005, Journal of neuroscience research.

[58]  D. Mele,et al.  Therapeutic Effects of l‐Carnitine and Propionyl‐l‐carnitine on Cardiovascular Diseases: A Review , 2004, Annals of the New York Academy of Sciences.

[59]  D. Hovda,et al.  Mitochondrial damage and dysfunction in traumatic brain injury. , 2004, Mitochondrion.

[60]  P. Blumbergs,et al.  Early Expression and Cellular Localization of Proinflammatory Cytokines Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-&agr; in Human Traumatic Spinal Cord Injury , 2004, Spine.

[61]  Ngan B. Doan,et al.  Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury , 2004, The Journal of Neuroscience.

[62]  J. Borg,et al.  Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. , 2004, Journal of rehabilitation medicine.

[63]  J. Turrens,et al.  Mitochondrial formation of reactive oxygen species , 2003, The Journal of physiology.

[64]  P. Kochanek,et al.  Assessment of Antioxidant Reserves and Oxidative Stress in Cerebrospinal Fluid after Severe Traumatic Brain Injury in Infants and Children , 2002, Pediatric Research.

[65]  Z. Binienda,et al.  Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity. , 2001, Toxicology letters.

[66]  I. Black,et al.  Brain-Derived Neurotrophic Factor in Astrocytes, Oligodendrocytes, and Microglia/Macrophages after Spinal Cord Injury , 2000, Neurobiology of Disease.

[67]  John DeLuca,et al.  Speed of Information Processing in Traumatic Brain Injury: Modality‐Specific Factors , 2000, The Journal of head trauma rehabilitation.

[68]  N. Greig,et al.  Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats. , 2000, Endocrinology.

[69]  Simon C Watkins,et al.  Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats , 2000, Journal of neurochemistry.

[70]  A. De Gaetano,et al.  L-carnitine improves glucose disposal in type 2 diabetic patients. , 1999, Journal of the American College of Nutrition.

[71]  G. Kelly.  L-Carnitine: therapeutic applications of a conditionally-essential amino acid. , 1998, Alternative medicine review : a journal of clinical therapeutic.

[72]  J. B. Hutchins,et al.  Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction , 1998, The Journal of Neuroscience.

[73]  M. Mattson,et al.  Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury , 1997, Brain Research.

[74]  Alan D. Lopez,et al.  Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study , 1997, The Lancet.

[75]  V. Mildažienė,et al.  Dependence of H2O2 Formation by Rat Heart Mitochondria on Substrate Availability and Donor Age , 1997, Journal of bioenergetics and biomembranes.

[76]  B Chance,et al.  Hydroperoxide metabolism in mammalian organs. , 1979, Physiological reviews.

[77]  N. Gadoth,et al.  Oxidative Stress and Free Radical Damage in Neurology , 2011 .

[78]  Michel Boulouard,et al.  The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice , 2009, Nature Protocols.

[79]  R. Linden,et al.  DNA damage-induced cell death: lessons from the central nervous system , 2008, Cell Research.

[80]  A. Evans,et al.  Pharmacokinetics of L-Carnitine , 2003, Clinical pharmacokinetics.

[81]  D. Santoro,et al.  History of L-carnitine: implications for renal disease. , 2003, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[82]  Elsa Lauwers,et al.  Synaptic Mitochondria in Synaptic Transmission and Organization of Vesicle Pools in Health and Disease , 2010, Front. Syn. Neurosci..