Glucagonlike peptide 1: a newly discovered gastrointestinal hormone.

[1]  B. Göke,et al.  Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung. , 2009, Experimental and clinical endocrinology.

[2]  G. Dockray,et al.  Gut Peptides: Biochemistry and Physiology , 1994 .

[3]  J. Holst,et al.  Subcutaneous Injection of the Incretin Hormone Glucagon-Like Peptide 1 Abolishes Postprandial Glycemia in NIDDM , 1994, Diabetes Care.

[4]  J. Holst,et al.  Proglucagon processing in porcine and human pancreas. , 1994, The Journal of biological chemistry.

[5]  John R. Christiansen,et al.  Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. , 1994, Scandinavian journal of gastroenterology.

[6]  S. Kahn,et al.  Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. , 1994, The Journal of clinical investigation.

[7]  J. Holst,et al.  Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans , 1994, Diabetes.

[8]  T. Kato,et al.  Stimulation of truncated glucagon-like peptide-1 release from the isolated perfused canine ileum by glucose absorption. , 1994, Digestion.

[9]  J. Holst,et al.  Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man. , 1994, Metabolism: clinical and experimental.

[10]  I. Valverde,et al.  Renal catabolism of truncated glucagon-like peptide 1. , 1993, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[11]  Shaoping Deng,et al.  Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor , 1993, Diabetes.

[12]  C. Strader,et al.  Cloning and functional expression of a human glucagon-like peptide-1 receptor. , 1993, Biochemical and biophysical research communications.

[13]  M. Permutt,et al.  Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. , 1993, Endocrinology.

[14]  B. Göke,et al.  GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery. , 1993, The American journal of physiology.

[15]  B. Göke,et al.  Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. , 1993, The Journal of biological chemistry.

[16]  M. Stoffel,et al.  Human Glucagon-Like Peptide-1 Receptor Gene: Localization to Chromosome Band 6p21 by Fluorescence In Situ Hybridization and Linkage of a Highly Polymorphic Simple Tandem Repeat DNA Polymorphism to Other Markers on Chromosome 6 , 1993, Diabetes.

[17]  M. Wheeler,et al.  Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C. , 1993, Endocrinology.

[18]  P. Brubaker,et al.  Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop. , 1993, Endocrinology.

[19]  V. Marks,et al.  Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. , 1993, The Journal of endocrinology.

[20]  J. Holst,et al.  Glucagon-Like Peptide 1: On Its Way to Clinical Application , 1993 .

[21]  B. Gallwitz,et al.  Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. , 1993, European journal of biochemistry.

[22]  J. Holst,et al.  Biological Effects and Metabolic Rates of Glucagonlike Peptide-1 7–36 Amide and Glucagonlike Peptide-1 7–37 in Healthy Subjects Are Indistinguishable , 1993, Diabetes.

[23]  M. Nauck,et al.  Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. , 1993, The Journal of clinical endocrinology and metabolism.

[24]  J. Habener,et al.  Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37) , 1993, Nature.

[25]  J. Holst,et al.  Effect of Intestinal Inhibitory Peptides on Vagally Induced Secretion from Isolated Perfused Porcine Pancreas , 1993, Pancreas.

[26]  J. Holst,et al.  GLP-1 : a humoral mediator of the ileal brake in humans ? , 1993 .

[27]  B. Göke,et al.  Regulation of glucagon-like peptide release from the isolated perfused rat ileum by nutrients, peptides and neuromediators , 1993 .

[28]  V. Go The Pancreas : biology, pathobiology, and disease , 1993 .

[29]  S. Efendić,et al.  Glucagon-like insulinotropic peptide has a stronger antidiabetogenic effect than glibenclamide , 1993 .

[30]  J. Holst,et al.  Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. , 1993, The Journal of clinical investigation.

[31]  M. Wheeler,et al.  The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). , 1993, Endocrinology.

[32]  I. Valverde,et al.  Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue. , 1993, Endocrinology.

[33]  P. Layer,et al.  [Regulation of gastrointestinal functions by the ileocecal area]. , 1992, Zeitschrift fur Gastroenterologie.

[34]  G. Singhg,et al.  Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea pig pancreas. Identification of a mammalian analogue of the reptilian peptide exendin-4. , 1992, The Journal of biological chemistry.

[35]  J. Habener,et al.  Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. , 1992, Trends in biochemical sciences.

[36]  B. Thorens Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Y. Matsuzawa,et al.  Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells. , 1992, Biochemical and biophysical research communications.

[38]  D. Buckley Analysis of the degradation of insulinotropin [GLP-1(7–37)] in human plasma and production of degradation resistant analogs , 1992, Regulatory Peptides.

[39]  J. Habener,et al.  Insulinotropic glucagonlike peptide-I(7–37)/(7–36)amide A new incretin hormone , 1992, Trends in Endocrinology & Metabolism.

[40]  J. Holst,et al.  Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. , 1992, The New England journal of medicine.

[41]  H. Vermeer,et al.  Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man , 1992, European journal of clinical investigation.

[42]  E. Blázquez,et al.  Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain , 1992, Neuropeptides.

[43]  D. Nathan,et al.  Insulinotropic Action of Glucagonlike Peptide-I-(7–37) in Diabetic and Nondiabetic Subjects , 1992, Diabetes Care.

[44]  J. Holst,et al.  All products of proglucagon are elevated in plasma from uremic patients. , 1992, The Journal of clinical endocrinology and metabolism.

[45]  J. Habener,et al.  Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. , 1992, Endocrinology.

[46]  P. Flatt Nutrient regulation of insulin secretion , 1992 .

[47]  S. Poulsen,et al.  Glucagonlike Peptide-I-(7–36)-Amide Receptors Only in Islets of Langerhans: Autoradiographic Survey of Extracerebral Tissues in Rats , 1991, Diabetes.

[48]  J. Habener,et al.  Functional receptors for the insulinotropic hormone glucagon‐like peptide‐I(7–37) on a somatostatin secreting cell line , 1991, FEBS letters.

[49]  J. Holst,et al.  Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. , 1991, The Journal of clinical investigation.

[50]  T. Suda,et al.  Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops. , 1990, Acta endocrinologica.

[51]  B. Eipper,et al.  The 108-kDA peptidylglycine alpha-amidating monooxygenase precursor contains two separable enzymatic activities involved in peptide amidation. , 1990, Biochemical and biophysical research communications.

[52]  S. Bloom,et al.  Glucagon-like peptide-1 (7-36)-NH2: a physiological inhibitor of gastric acid secretion in man. , 1990, The Journal of endocrinology.

[53]  M. Hiratsuka,et al.  Alterations of plasma immunoreactive glucagon-like peptide-1 behavior in non-insulin-dependent diabetics. , 1990, Diabetes research and clinical practice.

[54]  G. Weir,et al.  Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation. , 1990, Endocrinology.

[55]  W. Fujimoto,et al.  Effects of Glucagonlike Peptide l-(7–36) on Release of Insulin, Glucagon, and Somatostatin by Rat Pancreatic Islet Cell Monolayer Cultures , 1989, Diabetes.

[56]  J. Holst,et al.  Complete sequences of glucagon-like peptide-1 from human and pig small intestine. , 1989, The Journal of biological chemistry.

[57]  J. Holst,et al.  Carboxypeptidase‐B‐like processing of the C‐terminus of glucagon‐like peptide‐2 in pig and human small intestine , 1989, FEBS letters.

[58]  J. Holst,et al.  Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. , 1988, Endocrinology.

[59]  J. Holst,et al.  Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine. , 1988, The Journal of biological chemistry.

[60]  T. Krarup Immunoreactive gastric inhibitory polypeptide. , 1988, Endocrine reviews.

[61]  S. Bloom,et al.  GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN , 1987, The Lancet.

[62]  A. Wilks,et al.  Identical mRNA for preproglucagon in pancreas and gut. , 1987, European journal of biochemistry.

[63]  G. Weir,et al.  Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. , 1987, The Journal of clinical investigation.

[64]  J. Holst,et al.  Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut , 1987, FEBS letters.

[65]  J. Holst,et al.  Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. , 1986, Endocrinology.

[66]  L. Orci,et al.  Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. , 1986, The Journal of biological chemistry.

[67]  N. Yanaihara,et al.  Rat pancreas contains the proglucagon(64–69) fragment and arginine stimulates its release , 1985, FEBS letters.

[68]  J. Holst Gut glucagon, enteroglucagon, gut glucagonlike immunoreactivity, glicentin--current status. , 1983, Gastroenterology.

[69]  G. Bell,et al.  Hamster preproglucagon contains the sequence of glucagon and two related peptides , 1983, Nature.

[70]  Graeme I. Bell,et al.  Exon duplication and divergence in the human preproglucagon gene , 1983, Nature.

[71]  J. Holst Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin. , 1982, The Biochemical journal.

[72]  V. Mutt,et al.  Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum , 1982 .

[73]  L. Thim,et al.  Purification and chemical characterization of a glicentin-related pancreatic peptide (proglucagon fragment) from porcine pancreas. , 1982, Biochimica et biophysica acta.

[74]  V. Mutt,et al.  Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum , 1982, FEBS letters.

[75]  L. Thim,et al.  The primary structure of porcine glicentin (proglucagon) , 1981, Regulatory Peptides.

[76]  L. Thim,et al.  Relationship of glicentin to proglucagon and glucagon in the porcine pancreas , 1981, Nature.

[77]  J. Holst Evidence that glicentin contains the entire sequence of glucagon. , 1980, The Biochemical journal.

[78]  A. J. Hood,et al.  Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa. , 1979, The Journal of physiology.

[79]  V Marks,et al.  The enteroinsular axis. , 1978, Journal of clinical pathology. Supplement.