Autoimmune thrombocytopenia and neutropenia after remission induction therapy for acute leukaemia

Patients with acute leukaemia who are exposed to intensive chemotherapy, with or without radiotherapy, may remain thrombocytopenic or neutropenic in remission. The incidence of these prolonged cytopenias was examined retrospectively in 46 patients in remission and prospectively in 14 patients. The patients were tested for the presence of autoantibodies to platelets and neutrophils using a fluorescent antihuman globulin technique with paraformaldehyde‐fixed cells. In the retrospective study nine patients (20%) had neutrophil autoantibodies and seven (15%) had platelet autoantibodies; only one of the former had neutropenia and one of the latter thrombocytopenia. In the prospective study three (21%) had neutrophil autoantibodies and seven (50%) had platelet autoantibodies. One of the patients with platelet autoantibodies had transient thrombocytopenia, and shortened platelet survival was demonstrated. None of the patients with neutrophil autoantibodies had neutropenia.

[1]  J. Kelton.  PLATELET AUTOANTIBODIES IN SEPTICAEMIA , 1985, British journal of haematology.

[2]  M. Amylon,et al.  Immune thrombocytopenia associated with acute nonlymphocytic leukemia. , 1984, The Journal of pediatrics.

[3]  D. J. Perry,et al.  Hodgkin's disease presenting as idiopathic thrombocytopenic purpura. , 1984, Postgraduate medical journal.

[4]  W. Buchanan,et al.  The relationship among platelet-associated IgG, platelet lifespan, and reticuloendothelial cell function , 1984 .

[5]  D. Harmon,et al.  Autoimmune neutropenia, hemolytic anemia, and reticulocytopenia in Hodgkin's disease. , 1984, Annals of internal medicine.

[6]  A. Waters,et al.  Platelet‐ and Granulocyte‐Specific Antibodies after Allogeneic and Autologous Bone Marrow Grafts 1 , 1984, Vox sanguinis.

[7]  W. Buchanan,et al.  The relationship among platelet-associated IgG, platelet lifespan, and reticuloendothelial cell function. , 1984, Blood.

[8]  S. Devereux,et al.  Platelet associated IgG and immune thrombocytopenia in lymphoproliferative and autoimmune disorders. , 2008, Clinical and laboratory haematology.

[9]  R. Smeenk,et al.  Interference of IgG, IgG aggregates and immune complexes in tests for platelet autoantibodies , 1983, British journal of haematology.

[10]  P. Plotz.  AUTOANTIBODIES ARE ANTI-IDIOTYPE ANTIBODIES TO ANTIVIRAL ANTIBODIES , 1983, The Lancet.

[11]  R. Aster,et al.  Immune thrombocytopenia associated with carcinoma. , 1983, Annals of internal medicine.

[12]  Z. Handzel.  regulators of the T-cell system , 1983 .

[13]  Z. Handzel,et al.  Thymic hormones: inducers and. , 1983, Immunology today.

[14]  A. von dem Borne,et al.  Primary and secondary autoimmune thrombocytopenia. A serological and clinical analysis. , 2009, Scandinavian journal of haematology.

[15]  J. Turk,et al.  Effect of Cyclophosphamide on Immunological Control Mechanisms , 1982, Immunological reviews.

[16]  S. Weitzman,et al.  Lymphoma with autoimmune neutropenia and hepatic sinusoidal infiltration: a syndrome. , 1982, Annals of internal medicine.

[17]  L. Harker,et al.  Immune‐mediated platelet destruction and thrombocytopenia in patients with solid tumours , 1982, British journal of haematology.

[18]  S. Osman,et al.  The labelling of blood cells in plasma with 111In-tropolonate. , 1982, The British journal of radiology.

[19]  D. Shimm,et al.  Autoimmune granulocytopenia. , 1980, Annual review of medicine.

[20]  W. Rosse,et al.  Immune thrombocytopenia in lymphoproliferative diseases. , 1979, Blood.

[21]  F. Verheugt,et al.  Autoimmune Granulocytopenia: the Detection of Granulocyte Autoantibodies with the Immunofluorescence Test , 1978, British journal of haematology.

[22]  F. Oosterhof,et al.  A Simple Immunofluorescence Test for the Detection of Platelet Antibodies , 1978, British journal of haematology.

[23]  A. von dem Borne,et al.  THE DETECTION OF GRANULOCYTE ALLOANTIBODIES WITH AN INDIRECT IMMUNOFLUORESCENCE TEST , 1978, British journal of haematology.

[24]  C. Engelfriet,et al.  IgG4 Autoantibodies against Erythrocytes, without Increased Haemolysis: a Case Report , 1977, British journal of haematology.

[25]  F. Verheugt,et al.  The Detection of Granulocyte Alloantibodies with an Indirect Immunofluorescence Test , 1977, British journal of haematology.

[26]  D. Keast,et al.  Erythrocyte autoantibodies induced in mice immunized with rat erythrocytes. , 1973, Immunology.

[27]  J. Playfair,et al.  Induction of red cell autoantibodies in normal mice. , 1973, Nature: New biology.

[28]  I. B. Fridleifsson,et al.  Strontium Isotopes and Rare Earth Elements in Basalts from the Heimaey and Surtsey Volcanic Eruptions , 1973, Nature.

[29]  A. Schiller,et al.  Hodgkin's disease presenting as “idiopathic” thrombocytopenic purpura , 1972, Cancer.