Atracurium in the neonate. Dose‐response with halothane

Atracurium in doses of 40, 65, 85 or 100 μg·kg−1 was given to four groups of five neonates anaesthetized with nitrous oxide and halothane. The dose‐response relationship was determined by measurement of the EMG response to train‐of‐four stimulation. The doses calculated to produce 50 and 95% depression of the first twitch response were 56.3 and 101.3 μg·kg−1 respectively. These values are lower than those reported during nitrous oxide/oxygen/narcotic anaesthesia in neonates and older children breathing halothane. The change in train‐of‐four ratio during onset appeared similar to that observed in adults.

[1]  O. Meretoja,et al.  Influence of age on the dose‐response relationship of atracurium in paediatric patients , 1988, Acta anaesthesiologica Scandinavica.

[2]  E. Mortier,et al.  Comparison of evoked electromyography and mechanical activity during vecuronium-induced neuromuscular blockade. , 1988, European Journal of Anaesthesiology.

[3]  G. Meakin,et al.  Comparison of atracurium-induced neuromuscular blockade in neonates, infants and children. , 1988, British journal of anaesthesia.

[4]  N. Harper,et al.  Evoked electromyographic and mechanical responses of the adductor pollicis compared during the onset of neuromuscular blockade by atracurium or alcuronium, and during antagonism by neostigmine. , 1986, British journal of anaesthesia.

[5]  R. M. Jones,et al.  Factors affecting train-of-four fade. , 1985, British journal of anaesthesia.

[6]  L. M. Liu,et al.  Neuromuscular effects of atracurium in infants and children. , 1985, Anesthesiology.

[7]  R. Miller,et al.  Vecuronium‐induced Neuromuscular Blockade during Enflurane, Isoflurane, and Halothane Anesthesia in Humans , 1984, Anesthesiology.

[8]  D. Sigman,et al.  Conformational effects of volatile anesthetics on the membrane-bound acetylcholine receptor protein: facilitation of the agonist-induced affinity conversion. , 1983, Biochemistry.

[9]  D. R. Cook,et al.  Clinical pharmacology of atracurium in paediatric patients. , 1983, British journal of anaesthesia.

[10]  R. Katz,et al.  Modification of atracurium blockade by halothane and by suxamethonium. A review of clinical experience. , 1983, British Journal of Anaesthesia.

[11]  R. Friesen,et al.  Cardiovascular Depression during Halothane Anesthesia in Infants: A Study of Three Induction Techniques , 1982, Anesthesia and analgesia.

[12]  E. Yodlowski,et al.  Assessment of Neuromuscular Function in Infants , 1981, Anesthesiology.

[13]  N. Goudsouzian.  Maturation of neuromuscular transmission in the infant. , 1980, British journal of anaesthesia.

[14]  B. Waud.  Decrease in dose requirement of d-tubocurarine by volatile anesthetics. , 1980, Anesthesiology.

[15]  B. Waud.  Decrease in Dose Requireement of d‐Tubocurarine by Volatile Anesthetics , 1979 .

[16]  R. Kennedy,et al.  Neuromuscular Transmission in a Mammalian Preparation during Exposure to Enflurane , 1975, Anesthesiology.

[17]  W. L. Nastuk,et al.  Effect of halothane on neuromuscular transmission. , 1966, JAMA.