In situ microwave fixation provides an instantaneous snapshot of the brain metabolome

[1]  E. Taylor,et al.  Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments , 2022, bioRxiv.

[2]  Yingjun Zhao,et al.  Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease , 2022, Molecular neurodegeneration.

[3]  Garry P. Nolan,et al.  Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments , 2022, Immunity.

[4]  R. Paolicelli,et al.  Microglial metabolic flexibility: emerging roles for lactate , 2022, Trends in Endocrinology & Metabolism.

[5]  Chi Wang,et al.  In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[6]  Matthew S. Gentry,et al.  Emerging roles of N-linked glycosylation in brain physiology and disorders , 2021, Trends in Endocrinology & Metabolism.

[7]  J. D. del Río,et al.  Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease. , 2021, Brain : a journal of neurology.

[8]  B. Faubert,et al.  Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies. , 2021, Med.

[9]  V. Devanathan,et al.  Glucose metabolism in the brain: An update , 2021 .

[10]  R. Sun,et al.  Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics , 2020, Metabolites.

[11]  Tsang-Wei Tu,et al.  Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain using 1H‐MRS , 2020, NMR in biomedicine.

[12]  Bret N. Smith,et al.  "Musings on the wanderer: What's new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism." , 2020, American journal of physiology. Gastrointestinal and liver physiology.

[13]  Jéssica K A Macêdo,et al.  Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools , 2020, bioRxiv.

[14]  G. Cavestro,et al.  Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes , 2020, Acta Diabetologica.

[15]  Matthew S. Gentry,et al.  Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry. , 2020, Carbohydrate polymers.

[16]  Chi Wang,et al.  Improved workflow for mass spectrometry–based metabolomics analysis of the heart , 2020, The Journal of Biological Chemistry.

[17]  R. Michelucci,et al.  FDG-PET assessment and metabolic patterns in Lafora disease , 2019, European Journal of Nuclear Medicine and Molecular Imaging.

[18]  Gang Zhao,et al.  Upregulation Of Renal GLUT2 And SGLT2 Is Involved In High-Fat Diet-Induced Gestational Diabetes In Mice , 2019, Diabetes, metabolic syndrome and obesity : targets and therapy.

[19]  Gary D. Bader,et al.  Single-cell transcriptomic profiling of the aging mouse brain , 2019, Nature Neuroscience.

[20]  G. Yellen,et al.  Neurons rely on glucose rather than astrocytic lactate during stimulation , 2019, Journal of neuroscience research.

[21]  Matthew S. Gentry,et al.  Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion , 2019, bioRxiv.

[22]  L. Good,et al.  Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency , 2019, Science Translational Medicine.

[23]  M. Nedergaard,et al.  State-Dependent Changes in Brain Glycogen Metabolism. , 2019, Advances in neurobiology.

[24]  G. Dienel Brain Glucose Metabolism: Integration of Energetics with Function. , 2019, Physiological reviews.

[25]  R. Spang,et al.  Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR , 2018, Scientific Reports.

[26]  Douglas L. Rothman,et al.  Glycemic Variability and Brain Glucose Levels in Type 1 Diabetes , 2018, Diabetes.

[27]  M. Pletcher,et al.  Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes , 2018, Diabetes Care.

[28]  R. Deberardinis,et al.  Applications of metabolomics to study cancer metabolism. , 2018, Biochimica et biophysica acta. Reviews on cancer.

[29]  A. Drzezga,et al.  Clinical utility of FDG PET in Parkinson’s disease and atypical parkinsonism associated with dementia , 2018, European Journal of Nuclear Medicine and Molecular Imaging.

[30]  S. Lehtonen,et al.  Glucose Transporters in Diabetic Kidney Disease—Friends or Foes? , 2018, Front. Endocrinol..

[31]  Michael J. Dagley,et al.  DExSI: a new tool for the rapid quantitation of 13C-labelled metabolites detected by GC-MS , 2018, Bioinform..

[32]  P. Puigserver,et al.  Insulin regulation of gluconeogenesis , 2018, Annals of the New York Academy of Sciences.

[33]  J. Girard Glucagon, a key factor in the pathophysiology of type 2 diabetes. , 2017, Biochimie.

[34]  A. Lane,et al.  Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing , 2017, Nature Communications.

[35]  L. Szablewski Glucose transporters in healthy heart and in cardiac disease. , 2017, International journal of cardiology.

[36]  Sujuan Gao,et al.  Type 1 Diabetes Mellitus and Cognitive Impairments: A Systematic Review. , 2017, Journal of Alzheimer's disease : JAD.

[37]  A. Schousboe,et al.  Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-13C]Glucose and [1,2-13C]Acetate as Substrates , 2017, Neurochemical Research.

[38]  C. Boychuk,et al.  Glutamatergic drive facilitates synaptic inhibition of dorsal vagal motor neurons after experimentally induced diabetes in mice. , 2016, Journal of neurophysiology.

[39]  O. Fiehn Metabolomics by Gas Chromatography–Mass Spectrometry: Combined Targeted and Untargeted Profiling , 2016, Current protocols in molecular biology.

[40]  J. Mukherjee,et al.  Initial Assessment of β3-Adrenoceptor-Activated Brown Adipose Tissue in Streptozotocin-Induced Type 1 Diabetes Rodent Model Using [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography , 2015, Molecular imaging.

[41]  B. Smith,et al.  Molecular and functional changes in glucokinase expression in the brainstem dorsal vagal complex in a murine model of type 1 diabetes , 2015, Neuroscience.

[42]  R. Bucala,et al.  Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer’s disease , 2015, Journal of Neuroinflammation.

[43]  L. Tenori,et al.  Metabolomics profiling of pre-and post-anesthesia plasma samples of colorectal patients obtained via Ficoll separation , 2015, Metabolomics.

[44]  Sang J. Chung,et al.  A Lactate-Induced Response to Hypoxia , 2015, Cell.

[45]  Charles F. Burant,et al.  Impact of Anesthesia and Euthanasia on Metabolomics of Mammalian Tissues: Studies in a C57BL/6J Mouse Model , 2015, PloS one.

[46]  Jason W Locasale,et al.  Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step , 2014, eLife.

[47]  E. Airoldi,et al.  Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. , 2014, Cell reports.

[48]  S. M. de la Monte,et al.  Brain metabolic dysfunction at the core of Alzheimer's disease. , 2014, Biochemical pharmacology.

[49]  J. Geschwind,et al.  Tumor glycolysis as a target for cancer therapy: progress and prospects , 2013, Molecular Cancer.

[50]  A. Lammertsma,et al.  Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes , 2013, Diabetes.

[51]  R. Deberardinis,et al.  Metabolism of [U‐13C]glucose in human brain tumors in vivo , 2012, NMR in biomedicine.

[52]  E. Masliah,et al.  Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease , 2012, Neuroscience.

[53]  Dinesh Rakheja,et al.  2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated glioma patients , 2011, Nature Medicine.

[54]  M. Boly,et al.  Influence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity , 2011, Current opinion in anaesthesiology.

[55]  A. Nehlig,et al.  Ultra fast in vivo microwave irradiation for enhanced metabolic stability of brain biopsy samples during HRMAS NMR analysis , 2011, Journal of Neuroscience Methods.

[56]  M. J. Charron,et al.  Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice , 2011, Diabetes.

[57]  Michèle Allard,et al.  Brain fuel metabolism, aging, and Alzheimer's disease. , 2011, Nutrition (Burbank, Los Angeles County, Calif.).

[58]  R. Gruetter,et al.  Deep thiopental anesthesia alters steady‐state glucose homeostasis but not the neurochemical profile of rat cortex , 2010, Journal of neuroscience research.

[59]  O. Fiehn,et al.  FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. , 2009, Analytical chemistry.

[60]  David S. Wishart,et al.  MetaboAnalyst: a web server for metabolomic data analysis and interpretation , 2009, Nucleic Acids Res..

[61]  K. Behar,et al.  In situ 3D magnetic resonance metabolic imaging of microwave‐irradiated rodent brain: a new tool for metabolomics research , 2009, Journal of neurochemistry.

[62]  J. Im,et al.  Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress , 2009, Journal of Neurochemistry.

[63]  W. T. Cade,et al.  Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting , 2008, Physical Therapy.

[64]  E. Reiman,et al.  Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias , 2008, Journal of Nuclear Medicine.

[65]  Craig R. Malloy,et al.  Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR , 2007, Proceedings of the National Academy of Sciences.

[66]  R. Wennberg,et al.  The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis , 2007, Seizure.

[67]  I. Gabriely,et al.  Role of hepatic glycogen breakdown in defective counterregulation of hypoglycemia in intensively treated type 1 diabetes. , 2006, Diabetes.

[68]  C. Cobelli,et al.  Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. , 2004, Diabetes.

[69]  K. Petersen,et al.  Regulation of net hepatic glycogenolysis and gluconeogenesis during exercise: impact of type 1 diabetes. , 2004, The Journal of clinical endocrinology and metabolism.

[70]  J. O'Callaghan,et al.  Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteins , 2004, Journal of Neuroscience Methods.

[71]  Niall J. English,et al.  Molecular dynamics simulations of microwave heating of water , 2003 .

[72]  H. Kitagawa,et al.  Heparin and Heparan Sulfate Biosynthesis , 2002, IUBMB life.

[73]  R. V. Van Heertum,et al.  Imaging the metabolic footprint of Glut1 deficiency on the brain , 2002, Annals of neurology.

[74]  M. Roden,et al.  Effects of short-term improvement of insulin treatment and glycemia on hepatic glycogen metabolism in type 1 diabetes. , 2001, Diabetes.

[75]  R. Shulman,et al.  In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion , 2001, Journal of neurochemistry.

[76]  O. Fiehn,et al.  Metabolite profiling for plant functional genomics , 2000, Nature Biotechnology.

[77]  M. Jensen,et al.  Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. , 2000, Diabetes.

[78]  J. F. Staples,et al.  Relationships between enzymatic flux capacities and metabolic flux rates: nonequilibrium reactions in muscle glycolysis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[79]  T. J. French,et al.  Ischaemia and tissue pyruvate dehydrogenase activities in the rat: a comparison of the effects of cervical dislocation and pentobarbital anaesthesia. , 1986, Biochemistry international.

[80]  T. Zalewska,et al.  Energy utilization and changes in some intermediates of glucose metabolism in normal and hypoxic rat brain after decapitation. , 1979, Resuscitation.

[81]  G. Login Microwave fixation versus formalin fixation of surgical and autopsy tissue. , 1978, The American journal of medical technology.

[82]  C. Mayers Histological fixation by microwave heating. , 1970, Journal of clinical pathology.

[83]  H. C. Robinson,et al.  The biosynthesis of chondroitin sulfate. , 1966, Archives of biochemistry and biophysics.

[84]  R. Friede,et al.  Relations between postmortem alterations and glycolytic metabolism in the brain. , 1961, Experimental neurology.

[85]  A. Bernsmeier,et al.  [The glucose consumption of the brain & its dependence on the liver]. , 1958, Archiv fur Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift fur die gesamte Neurologie und Psychiatrie.