Imaging in neurodegenerative disorders: recent studies

Purpose of review Advances in neuroimaging have expanded its already central role in neurodegenerative disorders. Recent findings The main advances we emphasize are imaging of amyloid in Alzheimer's disease, serial co-registered magnetic resonance imaging in frontotemporal lobar degeneration and imaging of nigrostriatal dysfunction in dementia with Lewy bodies. Summary All of these techniques offer ways of improving diagnosis.

[1]  I. McKeith,et al.  Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. , 2004, Brain : a journal of neurology.

[2]  Agneta Nordberg,et al.  PET imaging of amyloid in Alzheimer's disease , 2004, The Lancet Neurology.

[3]  F. Fazio,et al.  Frontotemporal dementia: impact of P301L tau mutation on a healthy carrier , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[4]  Nick C Fox,et al.  Imaging cerebral atrophy: normal ageing to Alzheimer's disease , 2004, The Lancet.

[5]  Daniela Perani,et al.  Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration , 2005, Annals of neurology.

[6]  J. Kaye,et al.  Predicting the rate of cognitive decline in aging and early Alzheimer disease , 2004, Neurology.

[7]  A. Drzezga,et al.  Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study , 2004, Neurobiology of Aging.

[8]  W. Klunk,et al.  Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B , 2004, Annals of neurology.

[9]  B L Miller,et al.  Behavioral disorders in the frontal and temporal variants of frontotemporal dementia , 2004, Neurology.

[10]  E. David Williams,et al.  The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease , 2004, NeuroImage.

[11]  Alan A. Wilson,et al.  In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. , 2004, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[12]  C. Jack,et al.  Longitudinal characterization of two siblings with frontotemporal dementia and parkinsonism linked to chromosome 17 associated with the S305N tau mutation. , 2005, Brain : a journal of neurology.

[13]  Paul M. Thompson,et al.  Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effects , 2004, NeuroImage.

[14]  S. Gilman,et al.  Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease , 2004, Annals of neurology.

[15]  P. Scheltens,et al.  Advances in the early detection of Alzheimer's disease , 2004, Nature Reviews Neuroscience.

[16]  T Shallice,et al.  Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. , 2005, Brain : a journal of neurology.

[17]  M. Weiner,et al.  Cognition and anatomy in three variants of primary progressive aphasia , 2004, Annals of neurology.

[18]  Nick C Fox,et al.  Longitudinal Patterns of Regional Change on Volumetric MRI in Frontotemporal Lobar Degeneration , 2004, Dementia and Geriatric Cognitive Disorders.

[19]  Z Walker,et al.  Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand , 2002, Journal of neurology, neurosurgery, and psychiatry.

[20]  D. Silverman.  Brain 18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  Dag Aarsland,et al.  Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. , 2004, Archives of neurology.

[22]  Hisao Tachibana,et al.  Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging , 2005, Dementia and Geriatric Cognitive Disorders.

[23]  N. Herrmann,et al.  Medial temporal hypoperfusion and aggression in Alzheimer disease. , 2004, Archives of neurology.

[24]  Karl Herholz,et al.  In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease , 2004, NeuroImage.

[25]  I. McKeith,et al.  Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease , 2004, Neurology.

[26]  G. Alexander,et al.  Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. Jack,et al.  Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD , 2004, Neurology.

[28]  J. Baron,et al.  'In the course of time': a PET study of the cerebral substrates of autobiographical amnesia in Alzheimer's disease. , 2004, Brain : a journal of neurology.

[29]  Nick C Fox,et al.  Mapping the onset and progression of atrophy in familial frontotemporal lobar degeneration , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[30]  G. Small.  Neuroimaging as a Diagnostic Tool in Dementia with Lewy Bodies , 2003, Dementia and Geriatric Cognitive Disorders.

[31]  H. Soininen,et al.  Hippocampus and entorhinal cortex in mild cognitive impairment and early AD , 2004, Neurobiology of Aging.

[32]  T. Bekinschtein,et al.  White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer’s disease , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[33]  I. McKeith,et al.  Temporal lobe atrophy on MRI in Parkinson disease with dementia , 2005, Neurology.

[34]  S. Gilman,et al.  Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testing , 2005, Experimental Neurology.

[35]  M. Iyo,et al.  A simple method for the detection of abnormal brain regions in Alzheimer’s disease patients using [11C]MP4A: Comparison with [123I]IMP SPECT , 2004, Annals of nuclear medicine.