Encephalitozoon cuniculi antibodies in a specific-pathogen-free rabbit unit

We describe our discovery of Encephalitozoon cuniculi antibodies in a specific-pathogen-free rabbit colony. Small-sized samples had failed to reveal the presence of infection with a prevalence of about 5%. Using an India ink immunoreaction test by which we were able to visualize both negative and positive reactions, we were able to undertake a 100% screen of the colony of more than 700 rabbits and to repeat this 4 weeks later when we had culled the positive reactors. By collating the results of those tests with the results of tests on previously collected samples, we have been able to discuss and observe age and sex susceptibilities and the mode of transmission of the naturally occurring disease.

[1]  B S Kellett,et al.  A modified india-ink immunoreaction for the detection of encephalitozoonosis , 1978, Laboratory animals.

[2]  D. Pye,et al.  Isolation of Encephalitozoon cuniculi from urine samples , 1977, Laboratory animals.

[3]  T. Waller.  The india-ink immunoreaction: a method for the rapid diagnosis of encephalitozoonosis , 1977, Laboratory animals.

[4]  J. Cox.  Altered immune responsiveness associated with Encephalitozoon cuniculi infection in rabbits , 1977, Infection and immunity.

[5]  D. Pye,et al.  Serodiagnosis of nosematosis by immunofluorescence using cell-culture-grown organisms , 1975, Laboratory animals.

[6]  J. Shadduck,et al.  A diagnostic skin test for encephalitozoonosis (nosematosis) in rabbits. , 1972, Laboratory animal science.

[7]  N. King,et al.  Encephalitozoonosis: evidence for vertical transmission. , 1972, The Journal of infectious diseases.

[8]  J. Cox,et al.  Presumptive diagnosis of Nosema cuniculi in rabbits by immunofluorescence. , 1972, Research in veterinary science.

[9]  J. Shadduck,et al.  Encephalitozoonosis (nosematosis) and toxoplasmosis. , 1971, The American journal of pathology.

[10]  J. Bismanis.  Detection of latent murine nosematosis and growth of Nosema cuniculi in cell cultures. , 1970, Canadian journal of microbiology.

[11]  M. Petri.  Studies on Nosema cuniculi found in transplantable ascites tumours with a survey of microsporidiosis in mammals. , 1969, Acta pathologica et microbiologica Scandinavica. Supplement.

[12]  J. McC. Howell,et al.  The Production of Rabbits free from Lesions Associated with Encephalitozoon Cuniculi , 1968 .

[13]  J. Innes,et al.  Occult endemic encephalitozoonosis of the central nervous system of mice (Swiss-Bagg-O'Grady strain). , 1962, Journal of neuropathology and experimental neurology.

[14]  MEDICAL RESEARCH COUNCIL , 1931, British medical journal.

[15]  J. E. Mccartney.  BRAIN LESIONS OF THE DOMESTIC RABBIT , 1923, The Journal of experimental medicine.

[16]  J. H. Wright,et al.  INFECTIOUS MOTOR PARALYSIS IN YOUNG RABBITS , 1922, The Journal of experimental medicine.