Bio-sensing textile based patch with integrated optical detection system for sweat monitoring

Sensors, which can be integrated into clothing and used to measure biochemical changes in body fluids, such as sweat, constitute a major advancement in the area of wearable sensors. Initial applications for such technology exist in personal health and sports performance monitoring. However, sample collection is a complicated matter as analysis must be done in real-time in order to obtain a useful examination of its composition. This work outlines the development of a textile-based fluid handling platform which uses a passive pump to gather sweat and move it through a pre-defined channel for analysis. The system is tested both in vitro and in vivo. In addition, a pH sensor, which depends on the use of a pH sensitive dye and paired emitter-detector LEDs to measure colour changes, has been developed. In vitro and on-body trials have shown that the sensor has the potential to record real-time variations in sweat during exercise.

[1]  Oliver P Kreyden,et al.  Anatomy of the sweat glands, pharmacology of botulinum toxin, and distinctive syndromes associated with hyperhidrosis. , 2004, Clinics in dermatology.

[2]  P. Groscurth Anatomy of sweat glands. , 2002, Current problems in dermatology.

[3]  R. Daniels,et al.  Primary care , 1998, Nursing management.

[4]  Mark J. Patterson,et al.  The reproducibility of closed-pouch sweat collection and thermoregulatory responses to exercise–heat stress , 2004, European Journal of Applied Physiology.

[5]  J A Stone,et al.  National athletic trainers' association position statement: fluid replacement for athletes. , 2000, Journal of athletic training.

[6]  M. Nimmo,et al.  Acute effects of dehydration on sweat composition in men during prolonged exercise in the heat. , 2004, Acta physiologica Scandinavica.

[7]  S. Galloway,et al.  Effect of induced metabolic alkalosis on sweat composition in men. , 2002, Acta physiologica Scandinavica.

[8]  A. Lymberis,et al.  Wearable health systems: From smart technologies to real applications , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[9]  H. M. Emrich,et al.  pH of sweat of patients with cystic fibrosis , 1976, Klinische Wochenschrift.

[10]  B.R. Soller,et al.  Design of intravascular fiber optic blood gas sensors , 1994, IEEE Engineering in Medicine and Biology Magazine.

[11]  陶仲为,et al.  Hyponatremia , 2010 .

[12]  Shekhar Bhansali,et al.  Novel lactate and pH biosensor for skin and sweat analysis based on single walled carbon nanotubes , 2006 .

[13]  R. W. Bullard EFFECTS OF CARBON DIOXIDE INHALATION ON SWEATING. , 1964, Journal of applied physiology.

[14]  R. Laprade,et al.  Na+/H+ exchangers in the human eccrine sweat duct. , 2003, American journal of physiology. Cell physiology.

[15]  Rita Paradiso,et al.  A wearable health care system based on knitted integrated sensors , 2005, IEEE Transactions on Information Technology in Biomedicine.

[16]  G. R. Brisson,et al.  A simple and disposable sweat collector , 2004, European Journal of Applied Physiology and Occupational Physiology.

[17]  R. Paradiso,et al.  Wearable system for vital signs monitoring. , 2004, Studies in health technology and informatics.

[18]  Kenji Saga,et al.  Structure and function of human sweat glands studied with histochemistry and cytochemistry. , 2002, Progress in histochemistry and cytochemistry.

[19]  K. Lau,et al.  Novel fused-LEDs devices as optical sensors for colorimetric analysis. , 2004, Talanta.

[20]  D. Diamond,et al.  Wireless sensor networks and chemo-/biosensing. , 2008, Chemical reviews.

[21]  N. Taccini,et al.  Sensing Fabrics for Monitoring Physiological and Biomechanical Variables: E-textile solutions , 2006, 2006 3rd IEEE/EMBS International Summer School on Medical Devices and Biosensors.

[22]  A. V. Rawlings,et al.  Erroneous gender differences in axillary skin surface/sweat pH , 2001, International journal of cosmetic science.

[23]  Dermot Diamond,et al.  Bio-sensing textiles - Wearable Chemical Biosensors for Health Monitoring , 2007, BSN.

[24]  A. G. R. Whitehouse The dissolved constituents of human sweat. , 1935 .

[25]  S. Galloway,et al.  Variations in Regional Sweat Composition in Normal Human Males , 2000, Experimental physiology.

[26]  K. Lau,et al.  Quantitative colorimetric analysis of dye mixtures using an optical photometer based on LED array , 2006 .

[27]  T. Tsuda,et al.  Human perspiration measurement. , 1998, Physiological measurement.