Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in Apo E‐/‐ mice and rabbits fed a high fat and cholesterol diet (607.11)

Objective ‐‐ Glycosphingolipids are integral components of the cell membrane and have been shown to serve as messengers, transducing growth factor initiated phenotypes. Here we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atherosclerosis and arterial stiffness in transgenic mice and in rabbits.

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