Nuclear transplantation in mammals: Remodelling of transplanted nuclei under the influence of maturation promoting factor

Whilst the role of Maturation or M‐phase Promoting Factor (MPF) as a universal M‐phase regulator is well documented, much less attention has been paid to its role in nuclear transplantation experiments and especially to its influence upon remodelling of transplanted nuclei. There is currently wide acceptance that successful nuclear transplantation using differentiated nuclei is possible only in a cytoplasmic environment that is capable of inducing rapid nuclear de‐differentiation to a pronuclear‐like form. In this review our purpose is firstly, to outline the conditions under which such remodelling can be induced, and secondly, to extend the debate to include a consideration of whether complete nuclear remodelling is an absolute necessity for clonal development.

[1]  I. Wilmut,et al.  Sheep cloned by nuclear transfer from a cultured cell line , 1996, Nature.

[2]  I Wilmut,et al.  Cell cycle co-ordination in embryo cloning by nuclear transfer. , 1996, Reviews of reproduction.

[3]  P. Trefil,et al.  Response of avian nuclei to mammalian maturation promoting factor (MPF) , 1995, Zygote.

[4]  J. Fulka,et al.  Replicating DNA does not block germinal vesicle breakdown in mouse oocytes. , 1995, The Journal of experimental zoology.

[5]  R. Moor,et al.  5 Nuclear Transplantation in Mammalian Eggs and Embryos , 1995 .

[6]  J. Fulka,et al.  Chromosome condensation activity (CCA) in bisected C57BL/6JxCBA mouse oocytes. , 1995, Reproduction, fertility, and development.

[7]  N. Winston,et al.  The exit of mouse oocytes from meiotic M-phase requires an intact spindle during intracellular calcium release. , 1995, Journal of cell science.

[8]  J. Fulka,et al.  A reversible block at the G1/S border during cell cycle progression of mouse embryos. , 1994, The International journal of developmental biology.

[9]  J. Fulka,et al.  Sister chromatid separation and the metaphase-anaphase transition in mouse oocytes. , 1994, Developmental biology.

[10]  I Wilmut,et al.  Improved development to blastocyst of ovine nuclear transfer embryos reconstructed during the presumptive S-phase of enucleated activated oocytes. , 1994, Biology of reproduction.

[11]  J. Garrels,et al.  Alterations in protein synthesis following transplantation of mouse 8-cell stage nuclei to enucleated 1-cell embryos. , 1994, Developmental biology.

[12]  H. Cheong,et al.  Relationship between nuclear remodeling and subsequent development of mouse embryonic nuclei transferred to enucleated oocytes , 1994, Molecular reproduction and development.

[13]  J. Fulka,et al.  Kinetics of MPF and histone H1 kinase activity differ during the G2- to M-phase transition in mouse oocytes. , 1993, The International journal of developmental biology.

[14]  I. Wilmut,et al.  Nuclear-cytoplasmic interactions during the first cell cycle of nuclear transfer reconstructed bovine embryos: implications for deoxyribonucleic acid replication and development. , 1993, Biology of reproduction.

[15]  N. Winston,et al.  The metaphase II arrest in mouse oocytes is controlled through microtubule‐dependent destruction of cyclin B in the presence of CSF. , 1993, The EMBO journal.

[16]  J. Fulka,et al.  Early changes in embryonic nuclei fused to chemically enucleated mouse oocytes. , 1993, The International journal of developmental biology.

[17]  R. Schultz.  Regulation of zygotic gene activation in the mouse , 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.

[18]  H. Cheong,et al.  Birth of mice after transplantation of early cell-cycle-stage embryonic nuclei into enucleated oocytes. , 1993, Biology of reproduction.

[19]  J. Fulka,et al.  Noninvasive chemical enucleation of mouse oocytes , 1993, Molecular reproduction and development.

[20]  M. S. Szöllösi,et al.  Changes in embryonic 8-cell nuclei transferred by means of cell fusion to mouse eggs. , 1992, The International journal of developmental biology.

[21]  R. Moor,et al.  The fall of biological maturation promoting factor (MPF) and histone H1 kinase activity during anaphase and telophase in mouse oocytes , 1992, Molecular reproduction and development.

[22]  R. Moor,et al.  Reconstruction of ungulate embryos by nuclear transplantation , 1992 .

[23]  K. Naito,et al.  Comparison of histone H1 kinase activity during meiotic maturation between two types of porcine oocytes matured in different media in vitro. , 1992, Biology of reproduction.

[24]  N. H. Orr,et al.  Genomic potential of erythroid and leukocytic cells of Rana pipiens analyzed by nuclear transfer into diplotene and maturing oocytes. , 1992, Differentiation; research in biological diversity.

[25]  Y. Kato,et al.  Synchronous division of mouse two-cell embryos with nocodazole in vitro. , 1992, Journal of reproduction and fertility.

[26]  P. Collas,et al.  Influence of cell cycle stage of the donor nucleus on development of nuclear transplant rabbit embryos. , 1992, Biology of reproduction.

[27]  P. Collas,et al.  Effect of donor cell cycle stage on chromatin and spindle morphology in nuclear transplant rabbit embryos. , 1992, Biology of Reproduction.

[28]  R. Prather,et al.  Genomic potential in mammals. , 1991, Differentiation; research in biological diversity.

[29]  G. Schatten,et al.  Cytoplasmic modification of the nuclear lamina during pronuclear-like transformation of mouse blastomere nuclei , 1991, Mechanisms of Development.

[30]  J. Fulka,et al.  Nuclear transplantation in bovine embryo: Fine structural and autoradiographic studies , 1991, Molecular reproduction and development.

[31]  G. Schatten,et al.  The expression of nuclear lamin A and C epitopes is regulated by the developmental stage of the cytoplasm in mouse oocytes or embryos. , 1991, The Journal of experimental zoology.

[32]  R. Prather,et al.  Nuclear transplantation in the pig embryo: nuclear swelling. , 1990, The Journal of experimental zoology.

[33]  N. First,et al.  Development of preimplantation mammalian embryos. , 1989, Progress in clinical and biological research.

[34]  V. Kopečný.  High-resolution autoradiographic studies of comparative nucleologenesis and genome reactivation during early embryogenesis in pig, man and cattle. , 1989, Reproduction, nutrition, development.

[35]  A. Tarkowski,et al.  Remodeling of mouse thymocyte nuclei depends on the time of their transfer into activated, homologous oocytes. , 1988, Journal of cell science.

[36]  D. Szőllősi,et al.  'Blebbing' of the nuclear envelope of mouse zygotes, early embryos and hybrid cells. , 1988 .

[37]  J. Blow,et al.  A role for the nuclear envelope in controlling DNA replication within the cell cycle , 1988, Nature.

[38]  J. Tesarik,et al.  High-resolution autoradiographic localization of DNA-containing sites and RNA synthesis in developing nucleoli of human preimplantation embryos: a new concept of embryonic nucleologenesis. , 1987, Development.

[39]  M. Diberardino.  Genomic potential of differentiated cells analyzed by nuclear transplantation , 1987 .

[40]  A. Tarkowski,et al.  Remodelling of thymocyte nuclei in activated mouse oocytes: an ultrastructural study. , 1986, European journal of cell biology.

[41]  S. Willadsen,et al.  Nuclear transplantation in sheep embryos , 1986, Nature.

[42]  B. Maro,et al.  Mechanism of polar body formation in the mouse oocyte: an interaction between the chromosomes, the cytoskeleton and the plasma membrane. , 1986, Journal of embryology and experimental morphology.

[43]  G. Schatten,et al.  Microtubule configurations during fertilization, mitosis, and early development in the mouse and the requirement for egg microtubule-mediated motility during mammalian fertilization. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Solter,et al.  Nuclear transplantation in the mouse embryo by microsurgery and cell fusion. , 1983, Science.

[45]  T. Puck,et al.  Premature chromosome condensation and cell cycle analysis , 1977, Journal of cellular physiology.