Scientific Understanding of the Induced Membrane Technique: Current Status and Future Directions

Objectives: To review the most recent basic science advances made in relation to the induced membrane technique and how those relate to clinical practice, applications, and future research directions. Design: Review of the literature. Setting: Any trauma center which might encounter large segmental bone defects. Articles Reviewed: Basic science articles that looked at characteristics of the induced membrane published in the past 30 years. Intervention: None.

[1]  C. Boudot,et al.  Osteoclasts and their precursors are present in the induced‐membrane during bone reconstruction using the Masquelet technique , 2017, Journal of tissue engineering and regenerative medicine.

[2]  Esther J. Lee,et al.  Effects of Local Antibiotic Delivery from Porous Space Maintainers on Infection Clearance and Induction of an Osteogenic Membrane in an Infected Bone Defect. , 2016, Tissue engineering. Part A.

[3]  I. Marzi,et al.  Establishment and characterization of the Masquelet induced membrane technique in a rat femur critical‐sized defect model , 2016, Journal of tissue engineering and regenerative medicine.

[4]  C. Mauffrey,et al.  Reconstruction of Long Bone Infections Using the Induced Membrane Technique: Tips and Tricks , 2016, Journal of orthopaedic trauma.

[5]  M. Bosse,et al.  Osteogenic, stem cell and molecular characterisation of the human induced membrane from extremity bone defects , 2016, Bone & joint research.

[6]  F. Luo,et al.  Induced membrane technique for the treatment of bone defects due to post-traumatic osteomyelitis , 2016, Bone & joint research.

[7]  I. Marzi,et al.  Effect of the harvest procedure and tissue site on the osteogenic function of and gene expression in human mesenchymal stem cells , 2016, International journal of molecular medicine.

[8]  I. Marzi,et al.  Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat's femur. , 2016, Injury.

[9]  P. Giannoudis.  Treatment of bone defects: Bone transport or the induced membrane technique? , 2016, Injury.

[10]  G. Schmidmaier,et al.  RIA fractions contain mesenchymal stroma cells with high osteogenic potency. , 2015, Injury.

[11]  Benjamin C. Taylor,et al.  Treatment of Bone Loss With the Induced Membrane Technique: Techniques and Outcomes , 2015, Journal of orthopaedic trauma.

[12]  Z. Mao,et al.  A Systematic Review and Meta-Analysis of Ilizarov Methods in the Treatment of Infected Nonunion of Tibia and Femur , 2015, PloS one.

[13]  C. Mauffrey,et al.  Innovative strategies for the management of long bone infection: a review of the Masquelet technique , 2015, Patient Safety in Surgery.

[14]  S. Flohe,et al.  Reconstruction of septic diaphyseal bone defects with the induced membrane technique. , 2015, Injury.

[15]  F. Wei,et al.  Induction of granulation tissue for the secretion of growth factors and the promotion of bone defect repair , 2015, Journal of Orthopaedic Surgery and Research.

[16]  D. Hak,et al.  Local antibiotic therapy strategies in orthopaedic trauma: Practical tips and tricks and review of the literature. , 2015, Injury.

[17]  H. Isaksson,et al.  The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect , 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[18]  Cyril Mauffrey,et al.  Management of Segmental Bone Defects , 2015, The Journal of the American Academy of Orthopaedic Surgeons.

[19]  W. Walsh,et al.  The Masquelet Technique for Membrane Induction and the Healing of Ovine Critical Sized Segmental Defects , 2014, PloS one.

[20]  K. Yeung,et al.  Masquelet Technique for Treatment of Posttraumatic Bone Defects , 2014, TheScientificWorldJournal.

[21]  Zhaowei Lin,et al.  Effects of BMP2 and VEGF165 on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells , 2013, Experimental and therapeutic medicine.

[22]  Y. Shen,et al.  Histological characteristics of induced membranes in subcutaneous, intramuscular sites and bone defect. , 2013, Orthopaedics & traumatology, surgery & research : OTSR.

[23]  P. Giannoudis,et al.  Induced periosteum a complex cellular scaffold for the treatment of large bone defects. , 2013, Bone.

[24]  I. Tarkin,et al.  Open supracondylar femur fractures with bone loss in the polytraumatized patient - Timing is everything! , 2013, Injury.

[25]  M. Bosse,et al.  Genomewide Molecular and Biologic Characterization of Biomembrane Formation Adjacent to a Methacrylate Spacer in the Rat Femoral Segmental Defect Model , 2013, Journal of orthopaedic trauma.

[26]  Hannu-Ville Leskelä,et al.  The mechanism of action of induced membranes in bone repair. , 2013, The Journal of bone and joint surgery. American volume.

[27]  H. Sagi,et al.  Qualitative and quantitative differences between bone graft obtained from the medullary canal (with a Reamer/Irrigator/Aspirator) and the iliac crest of the same patient. , 2012, The Journal of bone and joint surgery. American volume.

[28]  M. Bosse,et al.  Osteogenic and chondrogenic potential of biomembrane cells from the PMMA‐segmental defect rat model , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[29]  L. Obert,et al.  Harvest of cortico-cancellous intramedullary femoral bone graft using the Reamer-Irrigator-Aspirator (RIA). , 2012, Orthopaedics & traumatology, surgery & research : OTSR.

[30]  B. French,et al.  Induced Membrane Technique for Reconstruction To Manage Bone Loss , 2012, The Journal of the American Academy of Orthopaedic Surgeons.

[31]  F. Fitoussi,et al.  Treatment of posttraumatic bone defects by the induced membrane technique. , 2012, Orthopaedics & traumatology, surgery & research : OTSR.

[32]  Derek J Donegan,et al.  Staged bone grafting following placement of an antibiotic spacer block for the management of segmental long bone defects. , 2011, Orthopedics.

[33]  Rozalia Dimitriou,et al.  Masquelet technique for the treatment of bone defects: tips-tricks and future directions. , 2011, Injury.

[34]  B. Norris,et al.  Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases. , 2010, Injury.

[35]  I. Marzi,et al.  RIA reamings and hip aspirate: a comparative evaluation of osteoprogenitor and endothelial progenitor cells. , 2010, Injury.

[36]  P. Cronier,et al.  Two-stage reconstruction of post-traumatic segmental tibia bone loss with nailing. , 2010, Orthopaedics & traumatology, surgery & research : OTSR.

[37]  Ashutosh Kumar Singh,et al.  Foreign body-induced granulation tissue is a source of adult stem cells. , 2010, Translational research : the journal of laboratory and clinical medicine.

[38]  A. Masquelet,et al.  The concept of induced membrane for reconstruction of long bone defects. , 2010, The Orthopedic clinics of North America.

[39]  D. Hak,et al.  Biological rationale for the intramedullary canal as a source of autograft material. , 2010, The Orthopedic clinics of North America.

[40]  T. Weber,et al.  Treatment of large segmental bone defects with reamer-irrigator-aspirator bone graft: technique and case series. , 2010, The Orthopedic clinics of North America.

[41]  Sylvain Catros,et al.  Subcutaneous‐induced membranes have no osteoinductive effect on macroporous HA‐TCP in vivo , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[42]  C. Pilapil,et al.  Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[43]  E. Schneider,et al.  Effect of re-implanted particles from intramedullary reaming on mechanical properties and callus formation. A laboratory study. , 2007, The Journal of bone and joint surgery. British volume.

[44]  V. Bousson,et al.  Long‐bone critical‐size defects treated with tissue‐engineered grafts: A study on sheep , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[45]  T. Flinkkilä,et al.  Staged method using antibiotic beads and subsequent autografting for large traumatic tibial bone loss , 2007, Acta orthopaedica.

[46]  N. P. Haas,et al.  Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. , 2006, Bone.

[47]  V. Bousson,et al.  Induction of a barrier membrane to facilitate reconstruction of massive segmental diaphyseal bone defects: an ovine model. , 2006, Veterinary surgery : VS.

[48]  D. Hose,et al.  Human reaming debris: a source of multipotent stem cells. , 2005, Bone.

[49]  F. Wei,et al.  One-stage reconstruction of composite bone and soft-tissue defects in traumatic lower extremities. , 2004, Plastic and reconstructive surgery.

[50]  J. K. Nulend,et al.  Viable osteoblastic potential of cortical reamings from intramedullary nailing , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[51]  A C Masquelet,et al.  Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[52]  Ming-Te Chen,et al.  Double-strut free vascular fibular grafting for reconstruction of the lower extremities. , 2003, Injury.

[53]  F. Bakker,et al.  Reaming debris in osteotomized sheep tibiae. , 2001, The Journal of trauma.

[54]  F. Fitoussi,et al.  [Reconstruction of the long bones by the induced membrane and spongy autograft]. , 2000, Annales de chirurgie plastique et esthetique.

[55]  F. Wei,et al.  Free fibula osteoseptocutaneous graft for reconstruction of segmental femoral shaft defects. , 1997, The Journal of trauma.