Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE 1 α signaling

France; Centre Hospitalier Universitaire Nice, Hôpital l’Archet, Département Digestif, 06200 Nice, France; Université Paris Descartes, Sorbonne Paris Cité; Paris, France; Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers; Paris, France; INSERM, U1138; Paris, France; Université Pierre et Marie Curie, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus; Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP; Paris, France; Department of Women's and Children's Health,

[1]  K. Schroder,et al.  NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. , 2017, Journal of hepatology.

[2]  P. Walter,et al.  Targeting IRE1 with small molecules counteracts progression of atherosclerosis , 2017, Proceedings of the National Academy of Sciences.

[3]  Robert Blissett,et al.  The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe , 2016, Hepatology.

[4]  T. Kanneganti,et al.  The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation , 2016, The Journal of cell biology.

[5]  V. Lagente,et al.  Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis , 2016, Bioscience reports.

[6]  J. Gugenheim,et al.  ER stress induces NLRP3 inflammasome activation and hepatocyte death , 2015, Cell Death and Disease.

[7]  J. Tavernier,et al.  Getting RIDD of RNA: IRE1 in cell fate regulation. , 2014, Trends in biochemical sciences.

[8]  P. Gual,et al.  Osteopontin deficiency aggravates hepatic injury induced by ischemia–reperfusion in mice , 2014, Cell Death and Disease.

[9]  A. Wree,et al.  NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice , 2014, Hepatology.

[10]  L. Galluzzi,et al.  Decoding cell death signals in liver inflammation. , 2013, Journal of hepatology.

[11]  S. Werner,et al.  Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. , 2013, Journal of hepatology.

[12]  L. Glimcher,et al.  Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. , 2012, Cell metabolism.

[13]  C. Croce,et al.  Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice. , 2012, Blood.

[14]  P. Greengard,et al.  IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. , 2012, Cell metabolism.

[15]  C. Hetz.  The unfolded protein response: controlling cell fate decisions under ER stress and beyond , 2012, Nature Reviews Molecular Cell Biology.

[16]  P. Walter,et al.  The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation , 2011, Science.

[17]  R. Green,et al.  Dysregulation of the unfolded protein response in db/db mice with diet‐induced steatohepatitis , 2011, Hepatology.

[18]  A. Dolganiuc,et al.  Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells , 2011, Hepatology.

[19]  Randal J. Kaufman,et al.  Endoplasmic reticulum stress in liver disease. , 2011, Journal of hepatology.

[20]  A. Koong,et al.  Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. , 2011, Blood.

[21]  G. Hotamisligil,et al.  Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease , 2010, Cell.

[22]  J. Mauer,et al.  Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance* , 2009, The Journal of Biological Chemistry.

[23]  S. Rensen,et al.  Gastrointestinal , Hepatobiliary and Pancreatic Pathology Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis , 2009 .

[24]  D. Kastner,et al.  Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. , 2009, Immunity.

[25]  F. Martinon,et al.  BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. , 2009, Molecular cell.

[26]  B. S. Mohammed,et al.  Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss , 2009, Diabetes.

[27]  M. Katze,et al.  UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.

[28]  L. Glimcher,et al.  Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1 , 2008, Science.

[29]  John Calvin Reed,et al.  BI-1 Regulates Endoplasmic Reticulum Ca2+ Homeostasis Downstream of Bcl-2 Family Proteins* , 2008, Journal of Biological Chemistry.

[30]  Ramesh Natarajan,et al.  Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. , 2008, Gastroenterology.

[31]  John Calvin Reed,et al.  Mice lacking bi-1 gene show accelerated liver regeneration. , 2007, Cancer research.

[32]  John Calvin Reed,et al.  Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[33]  M. Pagliassotti,et al.  Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. , 2006, Endocrinology.

[34]  H. Kaneto,et al.  Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes* , 2005, Journal of Biological Chemistry.

[35]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[36]  S. Lipton,et al.  BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. , 2004, Molecular cell.

[37]  S. Oyadomari,et al.  Roles of CHOP/GADD153 in endoplasmic reticulum stress , 2004, Cell Death and Differentiation.

[38]  Stevan R. Hubbard,et al.  IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA , 2002, Nature.

[39]  C. Barlow,et al.  Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α* , 1996, The Journal of Biological Chemistry.

[40]  D. Ron,et al.  Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). , 1992, The Journal of clinical investigation.

[41]  F. Schaffner,et al.  Nonalcoholic fatty liver disease. , 1986, Progress in liver diseases.