Relationship of C-reactive protein with hypertension and interactions between increased C-reactive protein and other risk factors on hypertension in Mongolian people, China.

BACKGROUND The relationship between C-reactive protein (CRP) concentration and hypertension and interactions between CRP and other risk factors on hypertension have not been studied in Mongolian people of Inner Mongolia, China. METHODS AND RESULTS A total of 767 hypertensives and 762 non-hypertensives people aged 30 or more were selected as participants for the case-control study. Lifestyle risk factors and family history of hypertension were investigated, body weight measured, fasting plasma glucose, blood lipids, insulin and CRP examined for all participants. After adjustment for covariates, high level of CRP (>or=2.54) were associated with hypertension and the odds ratio (OR) was 1.337. The participants were also divided into even quartiles of CRP, compared to the lowest quartile, multivariate adjusted OR were 1.144, 1.330, 1.556 for the second, third and fourth quartiles of CRP, respectively. There were significant interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension, corresponding relative excess risk due to interactions were 0.799 and 0.651, respectively. CONCLUSION Increased CRP was associated with hypertension, there were interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension in Mongolian people.

[1]  H. Ogawa,et al.  Coronary spasm is associated with chronic low-grade inflammation. , 2007, Circulation journal : official journal of the Japanese Circulation Society.

[2]  P. Veeraveedu,et al.  The optimal cut-off point of C-reactive protein as an optional component of metabolic syndrome in Japan. , 2006, Circulation journal : official journal of the Japanese Circulation Society.

[3]  K. Sung,et al.  C-reactive protein concentrations are related to insulin resistance and metabolic syndrome as defined by the ATP III report. , 2004, International journal of cardiology.

[4]  Paul M Ridker,et al.  Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? , 2004, Circulation.

[5]  Yasmin,et al.  C-Reactive Protein Is Associated With Arterial Stiffness in Apparently Healthy Individuals , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[6]  Heejung Bang,et al.  Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Coronary Heart Disease in Middle-Aged Men and Women in the Atherosclerosis Risk in Communities (ARIC) Study , 2004, Circulation.

[7]  P. Ridker,et al.  C-reactive protein and the risk of developing hypertension. , 2003, JAMA.

[8]  P. Macfarlane,et al.  Metabolic Syndrome With and Without C-Reactive Protein as a Predictor of Coronary Heart Disease and Diabetes in the West of Scotland Coronary Prevention Study , 2003, Circulation.

[9]  T. Henry,et al.  Detecting vulnerable plaque using peripheral blood: inflammatory and cellular markers. , 2003, Journal of interventional cardiology.

[10]  H. Yatsuya,et al.  The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state , 2003, International Journal of Obesity.

[11]  N. Cook,et al.  C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events: An 8-Year Follow-Up of 14 719 Initially Healthy American Women , 2003, Circulation.

[12]  Yuichiro Yamada,et al.  C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients. , 2002, Metabolism: clinical and experimental.

[13]  H. Parving,et al.  Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death. , 2002, Diabetes.

[14]  Natalia S. Rost,et al.  Plasma Concentration of C-Reactive Protein and Risk of Ischemic Stroke and Transient Ischemic Attack: The Framingham Study , 2001, Stroke.

[15]  P. López-Jaramillo,et al.  Is C-reactive protein an independent risk factor for essential hypertension? , 2001, Journal of hypertension.

[16]  S. Haffner,et al.  Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). , 2000, Circulation.

[17]  P. Ridker,et al.  Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. , 2000, Circulation.

[18]  P. Ridker,et al.  C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. , 2000, The New England journal of medicine.

[19]  A. Folsom,et al.  Chlamydia pneumoniae infection and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. , 1999, American journal of epidemiology.

[20]  C. Visser,et al.  C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? , 1999, Circulation.

[21]  J. Danesh,et al.  Risk factors for coronary heart disease and acute-phase proteins. A population-based study. , 1999, European heart journal.

[22]  K. Williams,et al.  Atherosclerosis--an inflammatory disease. , 1999, The New England journal of medicine.

[23]  R Sessa,et al.  Chlamydia pneumoniae infection and atherosclerotic coronary disease. , 1999, American heart journal.

[24]  S. Coppack,et al.  C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[25]  A. Döring,et al.  C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. , 1999, Circulation.

[26]  W. Koenig,et al.  C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[27]  E. Feskens,et al.  Chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but Helicobacter pylori and cytomegalovirus are not , 1998, Epidemiology and Infection.

[28]  L. Kuller,et al.  Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[29]  P. Ridker,et al.  Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. , 1997, The New England journal of medicine.

[30]  G. Vercellotti,et al.  C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor , 1993 .

[31]  K. Kayaba,et al.  Metabolic Syndrome and C-Reactive Protein in the General Population JMS Cohort Study , 2006 .

[32]  Hao Bing.  Serum C-reactive protein level is associated with essential hypertension , 2003 .

[33]  Harry,et al.  C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor. , 1993, Blood.