k 3D Deformable Magnetic Resonance Textbook Based on Elasticity

complex shape variability evident in intersubject oanatomies can be accommodated using GrenanGlobal Shape models. Following the approach of :, 3, 4], we construct a digitized textbook containall of the information currently available about a :al neuroanatomy on a fixed 3D coordinate system. textbook contains anatomical information (mag: resonance images, cryosection blockfaces, etc...) symbolic information (structure names, functions, actions with other structures, etc...). The textanatomy is individualized by deforming the shape .1atomic atlas images to match corresponding irafrom an individual. Symbolic information in the ~ook is then deformed and projected onto the inlual’s anatomy using the same estimated trans.ation. In addition, functional information such ~sitron emission tomography (PET) images in the .~ individual can be mapped back to the textbook omy using the inverse transformation. By removhe individual shape variability from functional imthe relationship between function and anatomy ~s a normal population can be delineated. Once ocation of normal function is established, abhorties associated with disease states can be detected.