Fiber Bragg Grating Sensors for Performance Evaluation of Fast Magnetic Resonance Thermometry on Synthetic Phantom

The increasing recognition of minimally invasive thermal treatment of tumors motivate the development of accurate thermometry approaches for guaranteeing the therapeutic efficacy and safety. Magnetic Resonance Thermometry Imaging (MRTI) is nowadays considered the gold-standard in thermometry for tumor thermal therapy, and assessment of its performances is required for clinical applications. This study evaluates the accuracy of fast MRTI on a synthetic phantom, using dense ultra-short Fiber Bragg Grating (FBG) array, as a reference. Fast MRTI is achieved with a multi-slice gradient-echo echo-planar imaging (GRE-EPI) sequence, allowing monitoring the temperature increase induced with a 980 nm laser source. The temperature distributions measured with 1 mm-spatial resolution with both FBGs and MRTI were compared. The root mean squared error (RMSE) value obtained by comparing temperature profiles showed a maximum error of 1.2 °C. The Bland-Altman analysis revealed a mean of difference of 0.1 °C and limits of agreement 1.5/−1.3 °C. FBG sensors allowed to extensively assess the performances of the GRE-EPI sequence, in addition to the information on the MRTI precision estimated by considering the signal-to-noise ratio of the images (0.4 °C). Overall, the results obtained for the GRE-EPI fully satisfy the accuracy (~2 °C) required for proper temperature monitoring during thermal therapies.

[1]  Kyriacos Kalli,et al.  Fiber Bragg Gratings: Fundamentals and Applications in Telecommunications and Sensing , 2000 .

[2]  E. Purcell,et al.  Relaxation Effects in Nuclear Magnetic Resonance Absorption , 1948 .

[3]  Emiliano Schena,et al.  In vivo image-guided MR thermometry during laser ablation: experience in kidney and liver , 2018, 2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[4]  Bruno Quesson,et al.  Magnetic resonance temperature imaging for guidance of thermotherapy , 2000, Journal of magnetic resonance imaging : JMRI.

[5]  O Søreide,et al.  Validation of estimated 3D temperature maps during hepatic cryo surgery. , 2001, Magnetic resonance imaging.

[6]  Daniele Tosi,et al.  Fiber Bragg Grating Sensor for Temperature Monitoring During HIFU Ablation of Ex Vivo Breast Fibroadenoma , 2019, IEEE Sensors Letters.

[7]  Hubert Cochet,et al.  Assessment of left ventricle magnetic resonance temperature stability in patients in the presence of arrhythmias , 2019, NMR in biomedicine.

[8]  D. Feinberg,et al.  Halving MR imaging time by conjugation: demonstration at 3.5 kG. , 1986, Radiology.

[9]  R. Turner,et al.  Echo-planar imaging: magnetic resonance imaging in a fraction of a second. , 1991, Science.

[10]  B. Hooper.  Optical-thermal response of laser-irradiated tissue , 1996 .

[11]  C. Moonen,et al.  MR thermometry for monitoring tumor ablation , 2007, European Radiology.

[12]  T. Nelson,et al.  Temperature dependence of proton relaxation times in vitro. , 1987, Magnetic resonance imaging.

[13]  Lars Frich.  Non‐invasive thermometry for monitoring hepatic radiofrequency ablation , 2006, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[14]  F. Izzo,et al.  New Approaches to the Treatment of Hepatic Malignancies Other Thermal Ablation Techniques: Microwave and Interstitial Laser Ablation of Liver Tumors , 2003 .

[15]  Assaf Govari,et al.  Improved cardiac magnetic resonance thermometry and dosimetry for monitoring lesion formation during catheter ablation , 2017, Magnetic resonance in medicine.

[16]  Henrik Odéen,et al.  Magnetic resonance thermometry and its biological applications - Physical principles and practical considerations. , 2019, Progress in nuclear magnetic resonance spectroscopy.

[17]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[18]  T E Conturo,et al.  Signal‐to‐noise in phase angle reconstruction: Dynamic range extension using phase reference offsets , 1990, Magnetic resonance in medicine.

[19]  D L Parker,et al.  Temperature distribution measurements in two-dimensional NMR imaging. , 1983, Medical physics.

[20]  R. R. Bowman.  A Probe for Measuring Temperature in Radio-Frequency-Heated Material (Short Papers) , 1976 .

[21]  K. Kuroda,et al.  A precise and fast temperature mapping using water proton chemical shift , 1995, Magnetic resonance in medicine.

[22]  Sergio Silvestri,et al.  Feasibility assessment of magnetic resonance-thermometry on pancreas undergoing laser ablation: Sensitivity analysis of three sequences , 2016 .

[23]  Bharat Gowardhan,et al.  Cryotherapy for the prostate: an in vitro and clinical study of two new developments; advanced cryoneedles and a temperature monitoring system , 2007, BJU international.

[24]  E. Samset,et al.  Temperature measurement in soft tissue using a distributed fibre Bragg-grating sensor system , 2001, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[25]  Alexandru Cernicanu,et al.  Validation of fast MR thermometry at 1.5 T with gradient‐echo echo planar imaging sequences: phantom and clinical feasibility studies , 2008, NMR in biomedicine.

[26]  Fritz Schick,et al.  Accuracy of real-time MR temperature mapping in the brain: a comparison of fast sequences. , 2010, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[27]  Emiliano Schena,et al.  Optical Fiber-Based MR-Compatible Sensors for Medical Applications: An Overview , 2013, Sensors.

[28]  Michael A. Davis,et al.  Fiber grating sensors , 1997 .

[29]  Rainer Schneider,et al.  Feasibility of real-time MR thermal dose mapping for predicting radiofrequency ablation outcome in the myocardium in vivo , 2017, Journal of Cardiovascular Magnetic Resonance.

[30]  T. Vogl,et al.  Temperature imaging of laser-induced thermotherapy (LITT) by MRI: evaluation of different sequences in phantom , 2013, Lasers in Medical Science.

[31]  A. Wolf,et al.  Femtosecond point-by-point inscription of Bragg gratings by drawing a coated fiber through ferrule. , 2016, Optics express.

[32]  Alfredo Cigada,et al.  Fiber-Optic Temperature and Pressure Sensors Applied to Radiofrequency Thermal Ablation in Liver Phantom: Methodology and Experimental Measurements , 2015, J. Sensors.

[33]  P van Gelderen,et al.  Fast magnetic-resonance temperature imaging. , 1996, Journal of magnetic resonance. Series B.

[34]  Paola Saccomandi,et al.  Spatially resolved thermometry during laser ablation in tissues: Distributed and quasi-distributed fiber optic-based sensing , 2020, Optical Fiber Technology.

[35]  Henrik Odéen,et al.  Improved MR thermometry for laser interstitial thermotherapy , 2019, Lasers in surgery and medicine.

[36]  R. R. Ernst,et al.  Application of Fourier Transform Spectroscopy to Magnetic Resonance , 1966 .

[37]  Elfed Lewis,et al.  Fiber Optic Sensors for Temperature Monitoring during Thermal Treatments: An Overview , 2016, Sensors.

[38]  Pierre Schnyder,et al.  Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems , 2003, European Radiology.

[39]  P. Walker,et al.  Preparation of agarose gels as reference substances for NMR relaxation time measurement. EEC Concerted Action Program. , 1988, Magnetic resonance imaging.

[40]  E Schena,et al.  Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver. , 2015, Medical engineering & physics.

[41]  K. Krebber,et al.  Medical Textiles With Embedded Fiber Optic Sensors for Monitoring of Respiratory Movement , 2012, IEEE Sensors Journal.

[42]  G. Gazelle,et al.  Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. , 2000, AJR. American journal of roentgenology.

[43]  Michael Schacht Hansen,et al.  Gadgetron: An open source framework for medical image reconstruction , 2013, Magnetic resonance in medicine.

[44]  E Schena,et al.  Temperature monitoring during microwave ablation in ex vivo porcine livers. , 2015, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[45]  Robin M Heidemann,et al.  Generalized autocalibrating partially parallel acquisitions (GRAPPA) , 2002, Magnetic resonance in medicine.

[46]  Hypolito José Kalinowski,et al.  A fibre optic Bragg grating strain sensor for monitoring ventilatory movements , 2001 .