Exploiting Dark Fluorophore States to Implement Resonance Energy Transfer Pre-Charge Logic

As lithographic feature sizes approach fundamental scaling limits, a variety of computational domains remain incompatible with integrated circuits merely due to their operating principles. Resonance energy transfer (RET) logic offers a molecular-scale solution for accessing these untapped domains. This emerging technology uses self-assembled networks of fluorescent molecules to perform computation at scales far below the diffraction limit and in environments that preclude silicon electronics. In this article, the authors propose a new form of RET logic design that yields a library of nonlinear logic gates that can be cascaded to build more complex integrated molecular circuits.

[2]  Chris L Dwyer,et al.  An Optically Modulated Self-Assembled Resonance Energy Transfer Pass Gate. , 2017, Nano letters.

[3]  Peng Yin,et al.  Genetic encoding of DNA nanostructures and their self-assembly in living bacteria , 2016, Nature Communications.

[4]  Chris Dwyer,et al.  Architectural implications of nanoscale integrated sensing and computing , 2009, ASPLOS.

[5]  Hao Yan,et al.  DNA Origami with Complex Curvatures in Three-Dimensional Space , 2011, Science.

[6]  G. Seelig,et al.  Dynamic DNA nanotechnology using strand-displacement reactions. , 2011, Nature chemistry.

[7]  Heather Duschl,et al.  DNA-enabled integrated molecular systems for computation and sensing. , 2014, Accounts of chemical research.

[8]  B. Valeur,et al.  Molecular Fluorescence: Principles and Applications , 2001 .

[9]  P. Rothemund Folding DNA to create nanoscale shapes and patterns , 2006, Nature.

[10]  Chris Dwyer,et al.  Encoded multichromophore response for simultaneous label-free detection. , 2010, Small.

[11]  X. Zhuang,et al.  Evaluation of Fluorophores for Optimal Performance in Localization-Based Super-Resolution Imaging , 2012 .

[12]  Mark Bates,et al.  Multicolor Super-Resolution Imaging with Photo-Switchable Fluorescent Probes , 2007, Science.

[13]  Chris Dwyer,et al.  Architectural Implications of Nanoscale-Integrated Sensing and Computing , 2010, IEEE Micro.

[14]  P ? ? ? ? ? ? ? % ? ? ? ? , 1991 .

[15]  Xue Han,et al.  Light-Triggered Release of Bioactive Molecules from DNA Nanostructures. , 2016, Nano letters.

[16]  Siyang Wang,et al.  Nanoscale Resonance Energy Transfer-Based Devices for Probabilistic Computing , 2015, IEEE Micro.

[18]  Mike Heilemann,et al.  Super-resolution imaging with small organic fluorophores. , 2009, Angewandte Chemie.

[19]  Mike Heilemann,et al.  Photoinduced formation of reversible dye radicals and their impact on super-resolution imaging , 2011, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.