Pediatric blunt renal trauma practice management guidelines: Collaboration between the Eastern Association for the Surgery of Trauma and the Pediatric Trauma Society

BACKGROUND Injury to the kidney from either blunt or penetrating trauma is the most common urinary tract injury. Children are at higher risk of renal injury from blunt trauma than adults, but no pediatric renal trauma guidelines have been established. The authors reviewed the literature to guide clinicians in the appropriate methods of management of pediatric renal trauma. METHODS Grading of Recommendations Assessment, Development and Evaluation methodology was used to aid with the development of these evidence-based practice management guidelines. A systematic review of the literature including citations published between 1990 and 2016 was performed. Fifty-one articles were used to inform the statements presented in the guidelines. When possible, a meta-analysis with forest plots was created, and the evidence was graded. RESULTS When comparing nonoperative management versus operative management in hemodynamically stable pediatric patient with blunt renal trauma, evidence suggests that there is a reduced rate of renal loss and blood transfusion in patients managed nonoperatively. We found that in pediatric patients with high-grade American Association for the Surgery of Trauma grade III-V (AAST III-V) renal injuries and ongoing bleeding or delayed bleeding, angioembolization has a decreased rate of renal loss compared with surgical intervention. We found the rate of posttraumatic renal hypertension to be 4.2%. CONCLUSION Based on the completed meta-analyses and Grading of Recommendations Assessment, Development and Evaluation profile, we are making the following recommendations: (1) In pediatric patients with blunt renal trauma of all grades, we strongly recommend nonoperative management versus operative management in hemodynamically stable patients. (2) In hemodynamically stable pediatric patients with high-grade (AAST grade III-V) renal injuries, we strongly recommend angioembolization versus surgical intervention for ongoing or delayed bleeding. (3) In pediatric patients with renal trauma, we strongly recommend routine blood pressure checks to diagnose hypertension. This review of the literature reveals limitations and the need for additional research on diagnosis and management of pediatric renal trauma. LEVEL OF EVIDENCE Guidelines study, level III.

[1]  S. Daniels,et al.  Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents , 2017, Pediatrics.

[2]  David M. Notrica,et al.  Nonoperative Management of Blunt Solid Organ Injury in Pediatric Surgery. , 2017, The Surgical clinics of North America.

[3]  S. Arslan,et al.  Management of high-grade renal injury in children , 2017, European Journal of Trauma and Emergency Surgery.

[4]  Tianyu Li,et al.  Unexpected High Rates of Angiography and Angioembolization for Isolated Low-grade Renal Trauma: Results From a Large, Statewide, Trauma Database. , 2016, Urology.

[5]  B. Gaines,et al.  Evolving Mechanisms of Injury and Management of Pediatric Blunt Renal Trauma--20 Years of Experience. , 2016, Urology.

[6]  J. N. Lee,et al.  Predictive factors for conservative treatment failure in grade IV pediatric blunt renal trauma. , 2016, Journal of pediatric urology.

[7]  D. Notrica Pediatric blunt abdominal trauma: current management , 2015, Current opinion in critical care.

[8]  Ross E. Anderson,et al.  The incidence of long-term hypertension in children after high-grade renal trauma. , 2015, Journal of pediatric surgery.

[9]  Chien-Heng Lin,et al.  The role of interventional radiology for pediatric blunt renal trauma , 2015, Italian Journal of Pediatrics.

[10]  S. Doğanay,et al.  Management of renal injury in children. , 2015, Annali italiani di chirurgia.

[11]  N. Lumen,et al.  Review of the current management of upper urinary tract injuries by the EAU Trauma Guidelines Panel. , 2015, European urology.

[12]  Mathew D. Sorensen,et al.  Demographics of pediatric renal trauma. , 2014, The Journal of urology.

[13]  M. Ost,et al.  Timing and predictors for urinary drainage in children with expectantly managed grade IV renal trauma. , 2014, The Journal of urology.

[14]  Thomas G. Smith,et al.  Urotrauma: AUA guideline. , 2014, The Journal of urology.

[15]  J. Recicar,et al.  The utility of initial and follow-up ultrasound reevaluation for blunt renal trauma in children and adolescents. , 2012, Journal of pediatric urology.

[16]  David M. Notrica,et al.  Prospective observational study with an abbreviated protocol in the management of blunt renal injury in children. , 2014, Journal of pediatric surgery.

[17]  T. Schuster,et al.  Selective Angioembolization in Blunt Solid Organ Injury in Children and Adolescents: Review of Recent Literature and Own Experiences , 2013, European Journal of Pediatric Surgery.

[18]  I. Geçit,et al.  Conservative Approach in the Treatment of Renal Trauma in Children , 2013, Urologia Internationalis.

[19]  R. Santucci,et al.  Computed tomography findings in patients with pediatric blunt renal trauma in whom expectant (nonoperative) management failed. , 2012, Urology.

[20]  E. Haut,et al.  The Eastern Association of the Surgery of Trauma approach to practice management guideline development using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology , 2012, The journal of trauma and acute care surgery.

[21]  J. Lazarus,et al.  Non-operative management of renal trauma in very young children: experiences from a dedicated South African paediatric trauma unit. , 2012, Injury.

[22]  F. Arena,et al.  Natural history of non-operative treatment for renal injuries in children. , 2012, Minerva Pediatrica.

[23]  F. Rivara,et al.  Conservative management vs early surgery for high grade pediatric renal trauma--do nephrectomy rates differ? , 2012, The Journal of urology.

[24]  G. Wei,et al.  Management of blunt renal trauma: an experience in 84 children , 2011, International Urology and Nephrology.

[25]  M. Hiremath,et al.  Severe renal injuries in children following blunt abdominal trauma: selective management and outcome , 2011, Pediatric Surgery International.

[26]  R. Santucci,et al.  Instituting a conservative management protocol for pediatric blunt renal trauma: evaluation of a prospectively maintained patient registry. , 2011, The Journal of urology.

[27]  A. Zisman,et al.  Use of adult criteria for slice imaging may limit unnecessary radiation exposure in children presenting with hematuria and blunt abdominal trauma. , 2011, Urology.

[28]  R. Karlsberg,et al.  Contrast-induced acute kidney injury (CI-AKI) following intra-arterial administration of iodinated contrast media. , 2010, Journal of nephrology.

[29]  S. S. St. Peter,et al.  Nonoperative management of blunt renal injury: a need for further study. , 2010, Journal of pediatric surgery.

[30]  Essam Kotb,et al.  Management of major blunt pediatric renal trauma: single-center experience. , 2010, Journal of pediatric urology.

[31]  D. Vane,et al.  Angiographic embolization is safe and effective therapy for blunt abdominal solid organ injury in children. , 2010, The Journal of trauma.

[32]  A. Morey,et al.  American Association for the Surgery of Trauma grade 4 renal injury substratification into grades 4a (low risk) and 4b (high risk). , 2010, The Journal of urology.

[33]  M. A. El-Ghar,et al.  Nonoperative management of grade 5 renal injury in children: does it have a place? , 2010, European urology.

[34]  S. Halachmi,et al.  Single center experience with application of the ALARA concept to serial imaging studies after blunt renal trauma in children--is ultrasound enough? , 2009, The Journal of urology.

[35]  M. Keller,et al.  Comparison of short- and long-term functional outcome of nonoperatively managed renal injuries in children. , 2009, Journal of pediatric surgery.

[36]  V. Master,et al.  Minimally invasive endovascular techniques to treat acute renal hemorrhage. , 2008, The Journal of urology.

[37]  D. Bulas,et al.  Management of high grade renal trauma: 20-year experience at a pediatric level I trauma center. , 2007, The Journal of urology.

[38]  H. Salem,et al.  Management of high-grade renal injuries in children after blunt abdominal trauma: experience of 40 cases. , 2007, Journal of pediatric urology.

[39]  Y. Shibamoto,et al.  Blunt renal trauma: comparison of contrast-enhanced CT and angiographic findings and the usefulness of transcatheter arterial embolization. , 2007, VASA. Zeitschrift fur Gefasskrankheiten.

[40]  E. Vaughan,et al.  Renal artery embolization: clinical indications and experience from over 100 cases , 2007, BJU international.

[41]  K. Strauss,et al.  The ALARA (as low as reasonably achievable) concept in pediatric interventional and fluoroscopic imaging: striving to keep radiation doses as low as possible during fluoroscopy of pediatric patients--a white paper executive summary. , 2006, Radiology.

[42]  Sue C. Kaste,et al.  The ALARA (as low as reasonably achievable) concept in pediatric interventional and fluoroscopic imaging: striving to keep radiation doses as low as possible during fluoroscopy of pediatric patients—a white paper executive summary , 2006, Pediatric Radiology.

[43]  R. Santucci,et al.  Pediatric blunt renal trauma: its conservative management and patterns of associated injuries. , 2006, Urology.

[44]  F. Rivara,et al.  American Association for the Surgery of Trauma Organ Injury Scale for kidney injuries predicts nephrectomy, dialysis, and death in patients with blunt injury and nephrectomy for penetrating injuries. , 2006, The Journal of trauma.

[45]  D. Canning High-grade renal injuries in children--is conservative management possible? , 2005, The Journal of urology.

[46]  R. Santucci,et al.  EAU guidelines on urological trauma. , 2005, European urology.

[47]  A. Morey Renovascular injury: an argument for renal preservation. , 2005, Journal of Urology.

[48]  M. Nance,et al.  Blunt renal injuries in children can be managed nonoperatively: outcome in a consecutive series of patients. , 2004, The Journal of trauma.

[49]  K. Macura,et al.  High-grade renal injuries in children--is conservative management possible? , 2004, Urology.

[50]  J. Mcaninch,et al.  Pediatric renal injuries: management guidelines from a 25-year experience. , 2004, The Journal of urology.

[51]  D. Partrick,et al.  Renovascular injury: an argument for renal preservation. , 2004 .

[52]  K. Sartorelli,et al.  Functional outcome of nonoperatively managed renal injuries in children. , 2004, The Journal of trauma.

[53]  Ayman Abu Hammad,et al.  Late renal functional and morphological evaluation after non‐operative treatment of high‐grade renal injuries in children , 2004, BJU international.

[54]  R. Santucci,et al.  Evaluation and management of renal injuries: consensus statement of the renal trauma subcommittee , 2004, BJU international.

[55]  H. Ozturk,et al.  Non-operative management of isolated solid organ injuries due to blunt abdominal trauma in children: a fifteen-year experience. , 2004, European journal of pediatric surgery.

[56]  A. Şencan,et al.  Blunt renal injuries in Turkish children: a review of 205 cases , 2003, Pediatric Surgery International.

[57]  S. Greenfield,et al.  The incidence of recreational genitourinary and abdominal injuries in the Western New York pediatric population. , 2003, The Journal of urology.

[58]  J. Mcaninch Blunt renal trauma in children: 26 years clinical experience in an alpine region. , 2003, Journal of Urology.

[59]  J. Elder,et al.  Sports participation and high grade renal injuries in children. , 2002, The Journal of urology.

[60]  J. Guys,et al.  Major renal injuries in children: the real incidence of kidney loss. , 2002, Journal of pediatric surgery.

[61]  G. Bartsch,et al.  Blunt renal trauma in children: 26 years clinical experience in an alpine region. , 2002, European urology.

[62]  A. Kirsch,et al.  Blunt traumatic hematuria in children. Is a simplified algorithm justified? , 2002, The Journal of urology.

[63]  J. Margenthaler,et al.  Blunt renal trauma in children: experience with conservative management at a pediatric trauma center. , 2002, The Journal of trauma.

[64]  D. Andrews,et al.  Management of grade IV renal injury in children. , 2001, The Journal of urology.

[65]  J. Elder,et al.  Are pediatric patients more susceptible to major renal injury from blunt trauma? A comparative study. , 1998, The Journal of urology.

[66]  M. Thompson-Fawcett,et al.  Paediatric renal trauma: caution with conservative management of major injuries. , 1996, The Australian and New Zealand journal of surgery.

[67]  S. Levitt,et al.  Optimal renal preservation with timely percutaneous intervention: a changing concept in the management of blunt renal trauma in children in the 1990s. , 1994, British journal of urology.

[68]  S. Zderic,et al.  Nonoperative management of blunt pediatric major renal trauma. , 1993, Urology.

[69]  G. Shaftan,et al.  Surgical management of pediatric renal trauma: an urban experience. , 1993, The American surgeon.

[70]  J. Elder,et al.  Major blunt renal trauma in the pediatric population: is a nonoperative approach indicated? , 1993, The Journal of urology.

[71]  P. Carroll,et al.  Renal reconstruction after injury. , 1991, The Journal of urology.

[72]  D. Bass,et al.  Investigation and management of blunt renal injuries in children: a review of 11 years' experience. , 1991, Journal of pediatric surgery.