An original method for staging sleep based on dynamical analysis of a single EEG signal

BACKGROUND The dynamical complexity of brain electrical activity manifested in the EEG is quantifiable using recurrence analysis (RA). Employing RA, we described and validated an originative method for automatically classifying epochs of sleep that is conceptually and instrumentally distinct from the existing method. NEW METHOD Complexity in single overnight EEGs was characterized second-by-second using four RA variables that were each averaged over consecutive 30-sec epochs to form four-component vectors. The vectors were staged using four-component cluster analysis. Method validity and utility were established by showing: (1) inter- and intra-subject consistency of staging results (method insusceptible to nonstationarity of the EEG); (2) use of method to eliminate costly and arduous visual staging in a binary classifications task for detecting a neurogenic disorder; (3) ability of method to provide new physiological insights into brain activity during sleep. RESULTS RA of sleep-acquired EEGs yielded four continuous measures of complexity and its change-rate that allowed automatic classification of epochs into four statistically distinct clusters ("stages"). Matched subjects with and without mental distress were accurately classified using biomarkers based on stage designations. COMPARISON WITH EXISTING METHODS For binary-classification purposes, the method was cheaper, faster, and at least as accurate as the existing staging method. Epoch-by-epoch comparison of new versus existing methods revealed that the latter assigned epochs having widely different dynamical complexities into the same stage (dynamical incoherence). CONCLUSIONS Sleep can be automatically staged using an originative method that is fundamentally different from the existing method.