The relationship between wasting and stunting in Cambodian children: Secondary analysis of longitudinal data of children below 24 months of age followed up until the age of 59 months

The interrelationship between wasting and stunting has been poorly investigated. We assessed the association between two indicators of linear growth, height-for-age Z-score (HAZ) change and occurrence of accelerated linear growth, and selected indicators of wasting and wasting reversal in 5,172 Cambodian children aged less than 24 months at enrolment in the ‘MyHealth’ study. The specific objectives were to evaluate the relationship between temporal changes in wasting and 1) change in HAZ and 2) episodes of accelerated linear growth. At enrolment, the stunting and wasting prevalence were 22.2 (21.0;23.3) % and 9.1 (8.1;10.1) %, respectively, and reached 41.4 (39.3;43.6) %, and 12.4 (11.5;13.3) % respectively, two years later. Between 14–19% of stunted children were also wasted throughout the whole study period. For each centimetre increase in Mid-Upper Arm Circumference (MUAC) from the previous assessment, the HAZ increased by 0.162 (0.150; 0.174) Z-score. We also observed a delayed positive association between the weight for height Z score (WHZ) unit increase and HAZ change of +0.10 to +0.22 units consistent with a positive relationship between linear growth and an increase in WHZ occurring with a lag of approximately three months. A similar positive correlation was observed for the occurrence of an episode of accelerated linear growth. These results show that interventions to prevent and treat wasting can contribute to stunting reduction and call for integrated wasting and stunting programming.

[1]  P. Bahwere,et al.  The Forgotten Agenda of Wasting in Southeast Asia: Burden, Determinants and Overlap with Stunting: A Review of Nationally Representative Cross-Sectional Demographic and Health Surveys in Six Countries , 2020, Nutrients.

[2]  N. Roos,et al.  Age-Appropriate Feeding Practices in Cambodia and the Possible Influence on the Growth of the Children: A Longitudinal Study , 2019, Nutrients.

[3]  F. Checchi,et al.  Child-Sensitive WASH Composite Score and the Nutritional Status in Cambodian Children , 2019, Nutrients.

[4]  A. Laillou,et al.  The Interaction between Morbidity and Nutritional Status among Children under Five Years Old in Cambodia: A Longitudinal Study , 2019, Nutrients.

[5]  S. Collins,et al.  Soya, maize and sorghum ready-to-use therapeutic foods are more effective in correcting anaemia and iron deficiency than the standard ready-to-use therapeutic food: randomized controlled trial , 2019, BMC Public Health.

[6]  Md. Mizanur Rahman,et al.  Reducing childhood malnutrition in Bangladesh: the importance of addressing socio-economic inequalities , 2019, Public Health Nutrition.

[7]  R. Grais,et al.  Linear growth faltering and the role of weight attainment: Prospective analysis of young children recovering from severe wasting in Niger , 2019, Maternal & child nutrition.

[8]  Jihye Kim,et al.  Risk factors for undernutrition among children 0–59 months of age in Myanmar , 2019, Proceedings of the Nutrition Society.

[9]  J. Wells,et al.  The relationship between wasting and stunting: a retrospective cohort analysis of longitudinal data in Gambian children from 1976 to 2016 , 2019, The American journal of clinical nutrition.

[10]  A. Briend,et al.  Concurrent wasting and stunting among under‐five children in Niakhar, Senegal , 2018, Maternal & child nutrition.

[11]  A. Dangour,et al.  Factors associated with catch‐up growth in early infancy in rural Pakistan: A longitudinal analysis of the women's work and nutrition study , 2018, Maternal & child nutrition.

[12]  Reza Ghadimi Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017 , 2018, Lancet.

[13]  R. Black,et al.  Relapse after severe acute malnutrition: A systematic literature review and secondary data analysis , 2018, Maternal & child nutrition.

[14]  L. De‐Regil,et al.  Prevalence thresholds for wasting, overweight and stunting in children under 5 years , 2018, Public Health Nutrition.

[15]  A. Laillou,et al.  Stunting, Beyond Acute Diarrhoea: Giardia Duodenalis, in Cambodia , 2018, Nutrients.

[16]  A. Briend,et al.  Children who are both wasted and stunted are also underweight and have a high risk of death: a descriptive epidemiology of multiple anthropometric deficits using data from 51 countries , 2018, Archives of Public Health.

[17]  P. Webb,et al.  Factors associated with wasting among children under five years old in South Asia: Implications for action , 2018, PloS one.

[18]  A. Laillou,et al.  Identification of Acute Malnutrition in Children in Cambodia Requires Both Mid Upper Arm Circumference and Weight-For-Height to Offset Gender Bias of Each Indicator , 2018, Nutrients.

[19]  A. Laillou,et al.  Diets and Feeding Practices during the First 1000 Days Window in the Phnom Penh and North Eastern Districts of Cambodia , 2018, Nutrients.

[20]  Y. Berhane,et al.  Choosing Anthropometric Indicators to Monitor the Response to Treatment for Severe Acute Malnutrition in Rural Southern Ethiopia—Empirical Evidence , 2017, Nutrients.

[21]  P. Bahwere,et al.  Use of tuberculin skin test for assessment of immune recovery among previously malnourished children in Ethiopia , 2017, BMC Research Notes.

[22]  Sinuon Muth,et al.  Strongyloides stercoralis is associated with significant morbidity in rural Cambodia, including stunting in children , 2017, PLoS neglected tropical diseases.

[23]  T. Khara,et al.  Children concurrently wasted and stunted: A meta‐analysis of prevalence data of children 6–59 months from 84 countries , 2017, Maternal & child nutrition.

[24]  J. Wells,et al.  Chronic disease outcomes after severe acute malnutrition in Malawian children (ChroSAM): a cohort study , 2016, The Lancet. Global health.

[25]  R. Moench-Pfanner,et al.  The Economic Burden of Malnutrition in Pregnant Women and Children under 5 Years of Age in Cambodia , 2016, Nutrients.

[26]  A. Laillou,et al.  Persistent Inequalities in Child Undernutrition in Cambodia from 2000 until Today , 2016, Nutrients.

[27]  A. Laillou,et al.  Inequalities in Nutrition between Cambodian Women over the Last 15 Years (2000–2014) , 2016, Nutrients.

[28]  C. Ritz,et al.  Short children with a low midupper arm circumference respond to food supplementation: an observational study from Burkina Faso. , 2016, The American journal of clinical nutrition.

[29]  M. Hoq,et al.  Relationship between mid upper arm circumference and weight changes in children aged 6–59 months , 2015, Archives of Public Health.

[30]  K. Reddy,et al.  The Global Nutrition Report 2014: actions and accountability to accelerate the world's progress on nutrition. , 2015, The Journal of nutrition.

[31]  A. Briend,et al.  Wasting and Stunting—Similarities and Differences: Policy and Programmatic Implications , 2015, Food and nutrition bulletin.

[32]  H. De Steur,et al.  Efficacy of mid-upper arm circumference in identification, follow-up and discharge of malnourished children during nutrition rehabilitation , 2015, Nutrition research and practice.

[33]  G. Fink,et al.  Childhood growth, schooling, and cognitive development: further evidence from the Young Lives study. , 2014, The American journal of clinical nutrition.

[34]  P. Engle,et al.  Postinfancy growth, schooling, and cognitive achievement: Young Lives , 2013, The American journal of clinical nutrition.

[35]  R. Martorell,et al.  Maternal and child undernutrition and overweight in low-income and middle-income countries , 2013, The Lancet.

[36]  Patrick Webb,et al.  Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? , 2013, The Lancet.

[37]  Soekirman,et al.  Key Strategies to Further Reduce Stunting in Southeast Asia: Lessons from the ASEAN Countries Workshop , 2013, Food and nutrition bulletin.

[38]  W. Fawzi,et al.  Associations of Suboptimal Growth with All-Cause and Cause-Specific Mortality in Children under Five Years: A Pooled Analysis of Ten Prospective Studies , 2013, PloS one.

[39]  J. Borja The impact of early nutrition on health: key findings from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). , 2013, Malaysian journal of nutrition.

[40]  W. Fawzi,et al.  The effect of multiple anthropometric deficits on child mortality: meta-analysis of individual data in 10 prospective studies from developing countries. , 2013, The American journal of clinical nutrition.

[41]  K. Maleta,et al.  Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery. , 2013, The Journal of nutrition.

[42]  F M Blows,et al.  Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer , 2011, British Journal of Cancer.

[43]  J. Stanford,et al.  Children who recover from early stunting and children who are not stunted demonstrate similar levels of cognition. , 2010, The Journal of nutrition.

[44]  R. Grais,et al.  Reducing Wasting in Young Children With Preventive Supplementation: A Cohort Study in Niger , 2010, Pediatrics.

[45]  Douglas G Altman,et al.  Comparison of techniques for handling missing covariate data within prognostic modelling studies: a simulation study , 2010, BMC medical research methodology.

[46]  Robert E Black,et al.  What works? Interventions for maternal and child undernutrition and survival , 2008, The Lancet.

[47]  J. Wells,et al.  Evaluation of Arm Anthropometry for Assessing Pediatric Body Composition: Evidence from Healthy and Sick Children , 2006, Pediatric Research.

[48]  C. Victora,et al.  Rapid growth in infancy and childhood and obesity in later life – a systematic review , 2005, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[49]  S. Virtanen,et al.  Seasonality of growth and the relationship between weight and height gain in children under three years of age in rural Malawi , 2003, Acta paediatrica.

[50]  D. S. Berkman,et al.  Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study , 2002, The Lancet.

[51]  M. Golden,et al.  Is complete catch-up possible for stunted malnourished children? , 1994, European journal of clinical nutrition.

[52]  S Greenland,et al.  Modeling and variable selection in epidemiologic analysis. , 1989, American journal of public health.

[53]  S. Walker,et al.  Growth in length of children recovering from severe malnutrition. , 1988, European journal of clinical nutrition.

[54]  R. Hayes,et al.  Seasonal variations in the nutritional status of urban Gambian children , 1986, British Journal of Nutrition.

[55]  R. Black,et al.  Patterns of physical growth in a longitudinal study of young children in rural Bangladesh. , 1982, The American journal of clinical nutrition.

[56]  T. Rikimaru What Are the Current Situations and the Challenges of Maternal and Child Malnutrition in Asia? , 2015, Journal of nutritional science and vitaminology.

[57]  L. Grummer-Strawn,et al.  Extension of the WHO maternal, infant and young child nutrition targets to 2030. , 2015 .

[58]  N. Cameron,et al.  The Human Growth Curve, Canalization and Catch-Up Growth , 2002 .