Induction of human pancreatic beta cell replication by inhibitors of dual specificity tyrosine regulated kinase

[1]  Javier León,et al.  Myc and cell cycle control. , 2015, Biochimica et biophysica acta.

[2]  T. Miyatsuka,et al.  Menin determines K-RAS proliferative outputs in endocrine cells. , 2014, The Journal of clinical investigation.

[3]  M. Atkinson,et al.  GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis , 2014, Diabetes.

[4]  Y. Hérault,et al.  Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance , 2014, Cell cycle.

[5]  A. Jain,et al.  Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease. , 2014, Current drug targets.

[6]  A. F. Stewart,et al.  Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map , 2014, Diabetes.

[7]  R. Scharfmann,et al.  Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass , 2014, Diabetologia.

[8]  R. Vasavada,et al.  Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration , 2013, Diabetes.

[9]  W. Becker,et al.  Mechanism of dual specificity kinase activity of DYRK1A , 2013, The FEBS journal.

[10]  Halit Ongen,et al.  Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome , 2013, Genome research.

[11]  Matthew S. Tremblay,et al.  Small-molecule inducer of β cell proliferation identified by high-throughput screening. , 2013, Journal of the American Chemical Society.

[12]  Taosheng Chen,et al.  Data Analysis Approaches in High Throughput Screening , 2013 .

[13]  R. Rizza,et al.  β-Cell Mass and Turnover in Humans , 2012, Diabetes Care.

[14]  D. I. Brierley,et al.  Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[15]  L. Meijer,et al.  Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. , 2012, Journal of medicinal chemistry.

[16]  A. F. Stewart,et al.  ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation , 2012, Diabetes.

[17]  G. Crabtree,et al.  Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. , 2012, Developmental cell.

[18]  Rohit N. Kulkarni,et al.  Human β-Cell Proliferation and Intracellular Signaling , 2012, Diabetes.

[19]  M. Atkinson,et al.  Formation of a human β-cell population within pancreatic islets is set early in life. , 2012, The Journal of clinical endocrinology and metabolism.

[20]  C. Rhodes,et al.  Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca2+-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells , 2011, Diabetes.

[21]  Amy E. Cox,et al.  cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. , 2011, Molecular endocrinology.

[22]  W. Sippl,et al.  Activation, regulation, and inhibition of DYRK1A , 2011, The FEBS journal.

[23]  Nobutoshi Ito,et al.  Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. , 2010, Nature communications.

[24]  A. F. Stewart,et al.  Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6 , 2010, Diabetes.

[25]  G. Evan,et al.  The ups and downs of Myc biology. , 2010, Current opinion in genetics & development.

[26]  Peter G. Schultz,et al.  Identification of small-molecule inducers of pancreatic β-cell expansion , 2009, Proceedings of the National Academy of Sciences.

[27]  A. F. Stewart,et al.  Survey of the Human Pancreatic β-Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human β-Cell Replication and Function In Vivo , 2009, Diabetes.

[28]  B. Sicari,et al.  Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines , 2008, Diabetes.

[29]  A. F. Stewart,et al.  Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets. , 2008 .

[30]  R. Rizza,et al.  β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans , 2008, Diabetes.

[31]  R. Mirmira.  Faculty Opinions recommendation of Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. , 2008 .

[32]  G. Evan,et al.  Regulated β-Cell Regeneration in the Adult Mouse Pancreas , 2008, Diabetes.

[33]  Marc Ferrer,et al.  Median Absolute Deviation to Improve Hit Selection for Genome-Scale RNAi Screens , 2008, Journal of biomolecular screening.

[34]  John S Lazo,et al.  Improved low molecular weight Myc-Max inhibitors , 2007, Molecular Cancer Therapeutics.

[35]  R. Damoiseaux,et al.  The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. , 2007, Cell metabolism.

[36]  J. Leahy,et al.  Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse , 2006, Diabetes.

[37]  J. Neilson,et al.  Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function , 2006, Nature.

[38]  G. Evan,et al.  Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms. , 2006, Cancer cell.

[39]  Robert A. Rizza,et al.  β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes , 2003, Diabetes.

[40]  X. Estivill,et al.  Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice , 2002, Molecular and Cellular Biology.

[41]  R. Palmiter,et al.  Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. , 2002, Diabetes.

[42]  G. Evan,et al.  Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression , 2002, Cell.

[43]  S. Pelengaris,et al.  Oncogenic co-operation in beta-cell tumorigenesis. , 2001, Endocrine-related cancer.

[44]  B. Glaser,et al.  Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. , 2000, Diabetes.

[45]  Thomas D. Y. Chung,et al.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.

[46]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[47]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[48]  R. Rizza,et al.  b-Cell Mass and Turnover in Humans Effects of obesity and aging , 2012 .

[49]  R. Rizza,et al.  Effects of obesity and aging , 2012 .

[50]  A. Tannapfel,et al.  Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas. , 2011, American journal of physiology. Endocrinology and metabolism.

[51]  Stella Pelengaris,et al.  Regulated beta-cell regeneration in the adult mouse pancreas. , 2008, Diabetes.

[52]  I. Wierstra,et al.  The c-myc promoter: still MysterY and challenge. , 2008, Advances in cancer research.

[53]  Meir Liebergall,et al.  Miniature Robotic Guidance for Spine Surgery , 2008 .

[54]  G. Crabtree,et al.  Lymphocyte calcium signaling from membrane to nucleus , 2005, Nature Immunology.

[55]  Robert A Rizza,et al.  Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. , 2003, Diabetes.

[56]  F. Alt,et al.  Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. , 2001, Immunity.

[57]  S. Pelengaris,et al.  Oncogenic co-operation in -cell tumorigenesis , 2001 .