Imaging Recommendations for Acute Stroke and Transient Ischemic Attack Patients: A Joint Statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery

SUMMARY: Stroke is a leading cause of death and disability worldwide. Imaging plays a critical role in evaluating patients suspected of acute stroke and transient ischemic attack, especially before initiating treatment. Over the past few decades, major advances have occurred in stroke imaging and treatment, including Food and Drug Administration approval of recanalization therapies for the treatment of acute ischemic stroke. A wide variety of imaging techniques has become available to assess vascular lesions and brain tissue status in acute stroke patients. However, the practical challenge for physicians is to understand the multiple facets of these imaging techniques, including which imaging techniques to implement and how to optimally use them, given available resources at their local institution. Important considerations include constraints of time, cost, access to imaging modalities, preferences of treating physicians, availability of expertise, and availability of endovascular therapy. The choice of which imaging techniques to employ is impacted by both the time urgency for evaluation of patients and the complexity of the literature on acute stroke imaging. Ideally, imaging algorithms should incorporate techniques that provide optimal benefit for improved patient outcomes without delaying treatment.

[1]  D L Schriger,et al.  Cranial computed tomography interpretation in acute stroke: physician accuracy in determining eligibility for thrombolytic therapy. , 1998, JAMA.

[2]  Takashi Inoue,et al.  Randomized Trial of Intraarterial Infusion of Urokinase Within 6 Hours of Middle Cerebral Artery Stroke: The Middle Cerebral Artery Embolism Local Fibrinolytic Intervention Trial (MELT) Japan , 2007, Stroke.

[3]  S. Warach,et al.  The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A Phase II MRI-Based 9-Hour Window Acute Stroke Thrombolysis Trial With Intravenous Desmoteplase , 2005, Stroke.

[4]  B R Rosen,et al.  Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time. , 1999, Radiology.

[5]  J. Alger,et al.  Impact on stroke subtype diagnosis of early diffusion-weighted magnetic resonance imaging and magnetic resonance angiography. , 2000, Stroke.

[6]  Erik Buskens,et al.  Imaging of carotid arteries in symptomatic patients: cost-effectiveness of diagnostic strategies. , 2004, Radiology.

[7]  Werner Hacke,et al.  Imaging-Based Decision Making in Thrombolytic Therapy for Ischemic Stroke: Present Status , 2003, Stroke.

[8]  Michael D Hill,et al.  Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. , 2013, The New England journal of medicine.

[9]  J. Grotta,et al.  Guidelines for Thrombolytic Therapy for Acute Stroke: a Supplement to the Guidelines for the Management of Patients with Acute Ischemic Stroke. A statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. , 1996, Stroke.

[10]  Stephen Rose,et al.  Diffusion‐ and perfusion‐weighted MRI response to thrombolysis in stroke , 2002, Annals of neurology.

[11]  S M Davis,et al.  Identification of major ischemic change. Diffusion-weighted imaging versus computed tomography. , 1999, Stroke.

[12]  M. Wintermark,et al.  Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association , 2013, Stroke.

[13]  S. Kasner,et al.  Is the ABCD Score Useful for Risk Stratification of Patients With Acute Transient Ischemic Attack? , 2006, Stroke.

[14]  L. Schwamm,et al.  The evolving role of acute stroke imaging in intravenous thrombolytic therapy: patient selection and outcomes assessment. , 2005, Neuroimaging clinics of North America.

[15]  M. E. Moseley,et al.  Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke , 1998, Neurology.

[16]  P. Rothwell,et al.  A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack , 2005, The Lancet.

[17]  S. Warach,et al.  Recommendations for imaging of acute ischemic stroke: a scientific statement from the American Heart Association. , 2009, Stroke.

[18]  A. Lepoutre,et al.  Critical review of non- or minimally invasive methods (duplex ultrasonography, MR- and CT-angiography) for evaluating stenosis of the proximal internal carotid artery. , 2002, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[19]  M. Jauss,et al.  Contribution of diffusion-weighted imaging in determination of stroke etiology. , 2006, AJNR. American journal of neuroradiology.

[20]  D B Matchar,et al.  Noninvasive Carotid Artery Testing: A Meta-analytic Review , 1995, Annals of Internal Medicine.

[21]  M. Ryan,et al.  Guidelines for the primary prevention of stroke : a guideline for health care professionals from the American Heart Association / American Stroke Association , 2013 .

[22]  B. Siewert,et al.  Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imaging , 1995, Annals of neurology.

[23]  M. Luby,et al.  Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison , 2007, The Lancet.

[24]  A. Demchuk,et al.  Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. , 2000, Lancet.

[25]  D. Schriger,et al.  Detection of early CT signs of >1/3 middle cerebral artery infarctions : interrater reliability and sensitivity of CT interpretation by physicians involved in acute stroke care. , 2000, Stroke.

[26]  M. Wintermark,et al.  A Pictorial Essay of Brain Perfusion‐CT: Not Every Abnormality Is a Stroke! , 2012, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[27]  Erik Buskens,et al.  Preoperative Diagnosis of Carotid Artery Stenosis: Accuracy of Noninvasive Testing , 2002, Stroke.

[28]  E. Vittinghoff,et al.  How Accurate Is CT Angiography in Evaluating Intracranial Atherosclerotic Disease? , 2008, Stroke.

[29]  T. Huisman,et al.  Intracranial hemorrhage: ultrasound, CT and MRI findings , 2005, European Radiology.

[30]  R. Bammer,et al.  Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute Stroke , 2009, Stroke.

[31]  J. Saver Time Is Brain—Quantified , 2006, Stroke.

[32]  C. Chung,et al.  Usefulness of triphasic perfusion computed tomography for intravenous thrombolysis with tissue-type plasminogen activator in acute ischemic stroke. , 2000, Archives of neurology.

[33]  A. Demchuk,et al.  Cerebral Microhemorrhages Predict New Disabling or Fatal Strokes in Patients With Acute Ischemic Stroke or Transient Ischemic Attack , 2006, Stroke.

[34]  M. E. Moseley,et al.  Clinical importance of microbleeds in patients receiving IV thrombolysis , 2005, Neurology.

[35]  Keith Muir,et al.  Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial , 2008, The Lancet Neurology.

[36]  L H Schwamm,et al.  Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. , 1999, Radiology.

[37]  W. Koroshetz,et al.  Contrast computed tomography scan in acute stroke: “You can't always get what you want but…you get what you need” , 2002, Annals of neurology.

[38]  Joseph P. Broderick,et al.  Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. , 1995 .

[39]  L. Caplan,et al.  Stroke Thrombolysis: Slow Progress , 2006, Circulation.

[40]  C. Levi,et al.  Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra. , 2013, Radiology.

[41]  Christopher Putman,et al.  Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:: Prediction of Final Infarct Volume and Clinical Outcome , 2001, Stroke.

[42]  W. Heiss,et al.  Does the Mismatch Match the Penumbra?: Magnetic Resonance Imaging and Positron Emission Tomography in Early Ischemic Stroke , 2005, Stroke.

[43]  J. Saver Intra-arterial fibrinolysis for acute ischemic stroke: the message of melt. , 2007, Stroke.

[44]  A. Demchuk,et al.  Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy , 2000, The Lancet.

[45]  Jeffrey L Saver,et al.  The Impact of Recanalization on Ischemic Stroke Outcome: A Meta-Analysis , 2007, Stroke.

[46]  C. Gerloff,et al.  [EU-funded treatment study: WAKE-UP: a randomized, placebo-controlled MRI-based trial of thrombolysis in wake-up stroke]. , 2012, Der Nervenarzt.

[47]  W. Hacke,et al.  Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke. , 1998, Stroke.

[48]  S. Kwon,et al.  Wake-Up or Unclear-Onset Strokes: Are they Waking up to the World of Thrombolysis Therapy? , 2012, International journal of stroke : official journal of the International Stroke Society.

[49]  Erich Bluhmki,et al.  Risk Factors for Severe Hemorrhagic Transformation in Ischemic Stroke Patients Treated With Recombinant Tissue Plasminogen Activator: A Secondary Analysis of the European-Australasian Acute Stroke Study (ECASS II) , 2001, Stroke.

[50]  M. Kaste,et al.  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. , 2008, The New England journal of medicine.

[51]  P. Vespa,et al.  Analysis of Thrombi Retrieved from Cerebral Arteries of Patients with Acute Ischemic Stroke. , 2005 .

[52]  L Bozzao,et al.  Early prediction of irreversible brain damage after ischemic stroke at CT. , 2001, Radiology.

[53]  P. Schellinger,et al.  Stroke-MRI: Extending the Time-Window: Recent Trials and Clinical Practice , 2007, International journal of stroke : official journal of the International Stroke Society.

[54]  A. Demchuk,et al.  Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study , 2012, The Lancet Neurology.

[55]  Gregory W Albers,et al.  Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials , 2010, The Lancet.

[56]  F Di Salle,et al.  Diffusion MRI in patients with transient ischemic attacks. , 1999, Stroke.

[57]  C. Levi,et al.  Perfusion computer tomography: imaging and clinical validation in acute ischaemic stroke. , 2011, Brain : a journal of neurology.

[58]  Gary A. Ford,et al.  Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. , 2008, Cerebrovascular diseases.

[59]  M. Wiesmann,et al.  Dynamic CT perfusion imaging of acute stroke. , 2000, AJNR. American journal of neuroradiology.

[60]  M. Moseley,et al.  Yield of combined perfusion and diffusion MR imaging in hemispheric TIA , 2009, Neurology.

[61]  E. Ringelstein,et al.  Detectability of cerebral hemisphere ischaemic infarcts by CT within 6 h of stroke , 2004, Neuroradiology.

[62]  W Hacke,et al.  Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. , 1994, AJNR. American journal of neuroradiology.

[63]  W. Hacke,et al.  Comparison of CT and CT Angiography Source Images With Diffusion-Weighted Imaging in Patients With Acute Stroke Within 6 Hours After Onset , 2002, Stroke.

[64]  M. Kaste,et al.  Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) , 1995, JAMA.

[65]  M. Edwards,et al.  Symptoms , 2008, The Lancet.

[66]  A. Doerfler,et al.  Feasibility and Safety of Magnetic Resonance Imaging-Based Thrombolysis in Patients with Stroke on Awakening: Initial Single-Centre Experience , 2010, International journal of stroke : official journal of the International Stroke Society.

[67]  M. Wintermark,et al.  Blood-Brain Barrier Permeability Assessed by Perfusion CT Predicts Symptomatic Hemorrhagic Transformation and Malignant Edema in Acute Ischemic Stroke , 2010, American Journal of Neuroradiology.

[68]  L. Goldstein,et al.  Clinical carotid endarterectomy decision making , 2001, Neurology.

[69]  P D Lyden,et al.  Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. , 1996, Circulation.

[70]  K. Furie,et al.  Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. , 2008, Stroke.

[71]  H. Rowley Extending the time window for thrombolysis: evidence from acute stroke trials. , 2005, Neuroimaging clinics of North America.

[72]  W. Heiss,et al.  Heterogeneity in the penumbra , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[73]  A. Fox,et al.  CT Angiographic Source Images: Flow- or Volume-Weighted? , 2011, American Journal of Neuroradiology.

[74]  Bing Wang,et al.  Imaging: Diagnostic Accuracy in Patients Imaged within 6 Hours of Stroke Symptom , 1999 .

[75]  R. Aviv,et al.  CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT , 2013, American Journal of Neuroradiology.

[76]  N. Salamon,et al.  CT and MRI Early Vessel Signs Reflect Clot Composition in Acute Stroke , 2011, Stroke.

[77]  Gary A. Ford,et al.  Multivariable Analysis of Outcome Predictors and Adjustment of Main Outcome Results to Baseline Data Profile in Randomized Controlled Trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST) , 2008, Stroke.

[78]  Jean-Philippe Thiran,et al.  Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients , 2002, Annals of neurology.

[79]  Patrick McElduff,et al.  Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography , 2010, Cerebrovascular Diseases.

[80]  A. Ferbert,et al.  Computed tomographic angiography findings in 103 patients following vascular events in the posterior circulation; potential and clinical relevance , 2000, Journal of Neurology.

[81]  Geoffrey A. Donnan,et al.  Refining the Definition of the Malignant Profile: Insights From the DEFUSE-EPITHET Pooled Data Set , 2011, Stroke.

[82]  Michael H Lev,et al.  Regional Ischemic Vulnerability of the Brain to Hypoperfusion: The Need for Location Specific Computed Tomography Perfusion Thresholds in Acute Stroke Patients , 2011, Stroke.

[83]  P. Freedson,et al.  Scientific Statement From the American Heart Association Guide to the Assessment of Physical Activity: Clinical and Research Applications: A , 2015 .

[84]  P. Sandercock,et al.  Magnetic resonance imaging versus computed tomography for detection of acute vascular lesions in patients presenting with stroke symptoms ( Review , 2022 .

[85]  C Marsault,et al.  Carotid artery stenosis: prospective comparison of CT, three-dimensional gadolinium-enhanced MR, and conventional angiography. , 2001, Radiology.

[86]  Zsolt Garami,et al.  Site of Arterial Occlusion Identified by Transcranial Doppler Predicts the Response to Intravenous Thrombolysis for Stroke , 2007, Stroke.

[87]  G. Zaharchuk,et al.  Arterial Spin Labeling Imaging Findings in Transient Ischemic Attack Patients: Comparison with Diffusion- and Bolus Perfusion-Weighted Imaging , 2012, Cerebrovascular Diseases.

[88]  Walter J Koroshetz,et al.  Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment. , 2005, AJNR. American journal of neuroradiology.

[89]  K. Sartor,et al.  Potential of CT angiography in acute ischemic stroke. , 1997, AJNR. American journal of neuroradiology.

[90]  À. Rovira,et al.  Distribution territories and causative mechanisms of ischemic stroke , 2005, European Radiology.

[91]  J. Alger,et al.  MR Mismatch Profiles in Patients with Intracranial Atherosclerotic Stroke: A Comprehensive approach Comparing Stroke Subtypes , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[92]  E. Ringelstein,et al.  Acute stroke assessment with CT: do we need multimodal evaluation? , 2004, Radiology.

[93]  Scott Hamilton,et al.  Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study , 2006, Annals of neurology.

[94]  S. Warach,et al.  Effect of citicoline on ischemic lesions as measured by diffusion‐weighted magnetic resonance imaging , 2000 .

[95]  Reto Meuli,et al.  Perfusion-CT Assessment of Infarct Core and Penumbra: Receiver Operating Characteristic Curve Analysis in 130 Patients Suspected of Acute Hemispheric Stroke , 2006, Stroke.

[96]  P D Lyden,et al.  Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy. , 1999, Stroke.

[97]  Geoffrey A. Donnan,et al.  RAPID Automated Patient Selection for Reperfusion Therapy: A Pooled Analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study , 2011, Stroke.

[98]  W. Hacke,et al.  CT and Diffusion-Weighted MR Imaging in Randomized Order: Diffusion-Weighted Imaging Results in Higher Accuracy and Lower Interrater Variability in the Diagnosis of Hyperacute Ischemic Stroke , 2002, Stroke.

[99]  A. Demchuk,et al.  Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. , 2001, AJNR. American journal of neuroradiology.

[100]  M. Wintermark,et al.  Contrast Extravasation on CT Predicts Mortality in Primary Intracerebral Hemorrhage , 2008, American Journal of Neuroradiology.

[101]  Javier M Romero,et al.  Total occlusion versus hairline residual lumen of the internal carotid arteries: accuracy of single section helical CT angiography. , 2003, AJNR. American journal of neuroradiology.

[102]  M E Moseley,et al.  Acute and chronic stroke: navigated spin-echo diffusion-weighted MR imaging. , 1996, Radiology.

[103]  S. Sen,et al.  CT Angiography in Acute Ischemic Stroke: Preliminary Results , 2002, Stroke.

[104]  F. Buonanno,et al.  Normal diffusion-weighted MRI during stroke-like deficits , 1999, Neurology.

[105]  C. Chung,et al.  Malignant Middle Cerebral Artery Infarction in Hyperacute Ischemic Stroke: Evaluation with Multiphasic Perfusion Computed Tomography Maps , 2004, Journal of computer assisted tomography.

[106]  S. Warach,et al.  Association of ischemic lesion patterns on early diffusion-weighted imaging with TOAST stroke subtypes. , 2003, Archives of neurology.

[107]  L. Wilkins Evidence-based guideline: The role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology , 2010, Neurology.

[108]  D. Shibata,et al.  CT angiography in the evaluation of acute stroke. , 1997, AJNR. American journal of neuroradiology.

[109]  Z. Chaudhry,et al.  Acute ischemic stroke: infarct core estimation on CT angiography source images depends on CT angiography protocol. , 2012, Radiology.

[110]  P. Schellinger The evolving role of advanced MR imaging as a management tool for adult ischemic stroke: a Western-European perspective. , 2005, Neuroimaging clinics of North America.

[111]  Sumon YusufPhotoshare Care , 1890, The Hospital.

[112]  S. Greenberg,et al.  CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage , 2012, Neurocritical Care.

[113]  A. Villringer,et al.  Stroke Magnetic Resonance Imaging Is Accurate in Hyperacute Intracerebral Hemorrhage: A Multicenter Study on the Validity of Stroke Imaging , 2004, Stroke.

[114]  Joanna Wardlaw,et al.  Stroke treatment with alteplase given 3·0–4·5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial , 2009, The Lancet Neurology.

[115]  R. Gonzalez,et al.  CT Cerebral Blood Flow Maps Optimally Correlate With Admission Diffusion-Weighted Imaging in Acute Stroke but Thresholds Vary by Postprocessing Platform , 2011, Stroke.

[116]  P. Barber,et al.  Refining the Perfusion—Diffusion Mismatch Hypothesis , 2005, Stroke.

[117]  M. Wintermark,et al.  Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke. , 2005, AJNR. American journal of neuroradiology.

[118]  Ivana Galinovic,et al.  DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study , 2011, The Lancet Neurology.

[119]  L. Caplan Treatment of acute stroke: still struggling. , 2004, JAMA.

[120]  John A Butman,et al.  Comparison of MRI and CT for detection of acute intracerebral hemorrhage. , 2004, JAMA.

[121]  SusanneWildermuth,et al.  Role of CT Angiography in Patient Selection for Thrombolytic Therapy in Acute Hemispheric Stroke , 1998 .

[122]  G. Duckwiler,et al.  Intracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography. , 2005, AJNR. American journal of neuroradiology.

[123]  I. Wilkinson,et al.  Imaging of haemorrhagic stroke. , 2002, Clinical radiology.

[124]  P. Vespa,et al.  Analysis of Thrombi Retrieved From Cerebral Arteries of Patients With Acute Ischemic Stroke , 2006, Stroke.

[125]  J. Kucharczyk,et al.  Diffusion/perfusion MR imaging of acute cerebral ischemia , 1991, Magnetic resonance in medicine.

[126]  J. Kalmár Autopsy correlations of computerized tomography: experience with 6,000 CT scans , 1977 .

[127]  R. Higashida,et al.  Density of Thrombus on Admission CT Predicts Revascularization Efficacy in Large Vessel Occlusion Acute Ischemic Stroke , 2013, Stroke.

[128]  M. Wintermark,et al.  Systematic comparison of perfusion‐CT and CT‐angiography in acute stroke patients , 2007, Annals of neurology.

[129]  J. Roh,et al.  Does microbleed predict haemorrhagic transformation after acute atherothrombotic or cardioembolic stroke? , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[130]  J. Ambrose,et al.  The EMI scanner. A brief review of the first 650 patients. , 1974, The British journal of radiology.

[131]  P. Sandercock,et al.  Very Early Risk of Stroke After a First Transient Ischemic Attack , 2003, Stroke.

[132]  Christoph Groden,et al.  Improvement of Sensitivity and Interrater Reliability to Detect Acute Stroke by Dynamic Perfusion Computed Tomography and Computed Tomography Angiography , 2006, Journal of computer assisted tomography.

[133]  C. Gerloff,et al.  EU-geförderte Therapiestudie WAKE-UP , 2012, Der Nervenarzt.

[134]  G. Newman,et al.  Fluid-Attenuated Inversion Recovery and Diffusion- and Perfusion-Weighted MRI Abnormalities in 117 Consecutive Patients With Stroke Symptoms , 2001, Stroke.

[135]  Steven Warach,et al.  Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): Evidence of Safety and Efficacy 3 to 9 Hours After Stroke Onset , 2006, Stroke.

[136]  Max Wintermark,et al.  Imaging of intracranial haemorrhage , 2008, The Lancet Neurology.

[137]  A. Demchuk,et al.  Silent ischemia in minor stroke and TIA patients identified on MR imaging , 2005, Neurology.

[138]  Henry Ma,et al.  Ischemic Thresholds for Gray and White Matter: A Diffusion and Perfusion Magnetic Resonance Study , 2006, Stroke.

[139]  T. Neumann-Haefelin,et al.  Bleeding Risk Analysis in Stroke Imaging Before ThromboLysis (BRASIL): Pooled Analysis of T2*-Weighted Magnetic Resonance Imaging Data From 570 Patients , 2007, Stroke.

[140]  S. Warach,et al.  Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study , 2009, The Lancet Neurology.

[141]  Gottfried Schlaug,et al.  Ischemic lesion volumes in acute stroke by diffusion‐weighted magnetic resonance imaging correlate with clinical outcome , 1997, Annals of neurology.

[142]  S. Napel,et al.  Circle of Willis: evaluation with spiral CT angiography, MR angiography, and conventional angiography. , 1995, Radiology.

[143]  Max Wintermark,et al.  A trial of imaging selection and endovascular treatment for ischemic stroke. , 2013, The New England journal of medicine.

[144]  Koroshetz Wj,et al.  Tissue plasminogen activator for acute ischemic stroke. , 1996, The New England journal of medicine.

[145]  D. Liebeskind,et al.  Collateral Flow Predicts Response to Endovascular Therapy for Acute Ischemic Stroke , 2011, Stroke.

[146]  Klaus Sartor,et al.  Comparison of Perfusion Computed Tomography and Computed Tomography Angiography Source Images With Perfusion-Weighted Imaging and Diffusion-Weighted Imaging in Patients With Acute Stroke of Less Than 6 Hours’ Duration , 2004, Stroke.

[147]  R R Edelman,et al.  Clinical experience with diffusion-weighted MR in patients with acute stroke. , 1998, AJNR. American journal of neuroradiology.

[148]  Manabu Inoue,et al.  MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study , 2012, The Lancet Neurology.

[149]  M. Jacobs,et al.  Assessment of transient ischemic attack with diffusion- and perfusion-weighted imaging. , 2004, AJNR. American journal of neuroradiology.

[150]  Michela Ponzio,et al.  Endovascular treatment for acute ischemic stroke. , 2013, The New England journal of medicine.

[151]  T. Hirai,et al.  Prospective evaluation of suspected stenoocclusive disease of the intracranial artery: combined MR angiography and CT angiography compared with digital subtraction angiography. , 2002, AJNR. American journal of neuroradiology.

[152]  J. Grotta,et al.  Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. , 2001, JAMA.

[153]  A. Demchuk,et al.  Alberta Stroke Program Early CT Score in acute stroke triage. , 2005, Neuroimaging clinics of North America.