Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells

1. In the present study, we sought to determine whether physiological or pathophysiological concentrations of obesity related peptides influence the key early atherogenic events of monocyte adhesion to endothelial cells and adhesion molecule expression using primary human cells.

[1]  C. Sigmund,et al.  Ghrelin Inhibits Proinflammatory Responses and Nuclear Factor-κB Activation in Human Endothelial Cells , 2004, Circulation.

[2]  J. Rood,et al.  Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. , 2004, The Journal of clinical endocrinology and metabolism.

[3]  A. Consoli,et al.  Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase , 2004, Diabetologia.

[4]  R. Nagai,et al.  Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. , 2004, Biochemical and biophysical research communications.

[5]  D. Stejskal,et al.  Resistin - concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. , 2003, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[6]  D. Zou,et al.  Serum resistin level in essential hypertension patients with different glucose tolerance , 2003, Diabetic medicine : a journal of the British Diabetic Association.

[7]  S. Verma,et al.  Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction , 2003, Circulation.

[8]  K. Steinbeck,et al.  Death in adults with Prader-Willi syndrome may be correlated with maternal uniparental disomy , 2003, Journal of medical genetics.

[9]  C. Mantzoros,et al.  Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. , 2003, The Journal of clinical endocrinology and metabolism.

[10]  K. Pacak,et al.  Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. , 2003, The Journal of clinical endocrinology and metabolism.

[11]  Yongwen Qin,et al.  [The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure]. , 2002, Zhonghua yi xue za zhi.

[12]  J. Bunt,et al.  High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. , 2002, The Journal of clinical endocrinology and metabolism.

[13]  J. Heyn,et al.  Plasma Resistin Levels in Patients with Type 1 and Type 2 Diabetes Mellitus and in Healthy Controls , 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[14]  J. Cooke,et al.  Does leptin cause vascular disease? , 2002, Circulation.

[15]  K. Kangawa,et al.  Vasodilatory Effect of Ghrelin, an Endogenous Peptide From the Stomach , 2002, Journal of cardiovascular pharmacology.

[16]  Márta Korbonits,et al.  The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. , 2002, The Journal of clinical endocrinology and metabolism.

[17]  E. Dellinger,et al.  Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. , 2002, The New England journal of medicine.

[18]  O. Wagner,et al.  Leptin Induces Endothelin-1 in Endothelial Cells In Vitro , 2002, Circulation research.

[19]  K. Chayama,et al.  Leptin causes vasodilation in humans. , 2002, Hypertension research : official journal of the Japanese Society of Hypertension.

[20]  B. Stoffel‐Wagner Neurosteroid metabolism in the human brain. , 2001, European journal of endocrinology.

[21]  D. Loskutoff,et al.  The Prothrombotic Effects of Leptin , 2001 .

[22]  D. Celermajer,et al.  Endothelin-1 plus oxidized low-density lipoprotein, but neither alone, increase human monocyte adhesion to endothelial cells. , 2001, Clinical science.

[23]  M. Tschöp,et al.  Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. , 2001, European journal of endocrinology.

[24]  A. Davenport,et al.  [125I‐His9]‐Ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue; up‐regulation of receptors with atherosclerosis , 2001 .

[25]  F. Parhami,et al.  Leptin Enhances the Calcification of Vascular Cells: Artery Wall as a Target of Leptin , 2001, Circulation research.

[26]  E. Ravussin,et al.  Circulating ghrelin levels are decreased in human obesity. , 2001, Diabetes.

[27]  J. Seidell,et al.  Obesity, insulin resistance and diabetes — a worldwide epidemic , 2000, British Journal of Nutrition.

[28]  I. Maruyama,et al.  Effect of Leptin in Platelet and Endothelial Cells: Obesity and Arterial Thrombosis , 2000, Annals of the New York Academy of Sciences.

[29]  P. Kopelman Obesity as a medical problem , 2000, Nature.

[30]  L. Fratta,et al.  Leptin induces direct vasodilation through distinct endothelial mechanisms. , 2000, Diabetes.

[31]  T Nakamura,et al.  Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. , 1999, Circulation.

[32]  M. Nakazato,et al.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach , 1999, Nature.

[33]  C. Ferri,et al.  Effects of insulin on in vitro vascular cell adhesion molecule-1 expression and in vivo soluble VCAM-1 release , 1999, Diabetologia.

[34]  David Handelsman,et al.  Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. , 1999, Circulation.

[35]  Ronald M. Krauss,et al.  American Heart Association Call to Action: Obesity as a Major Risk Factor for Coronary Heart Disease , 1998 .

[36]  Patrick R. Griffin,et al.  A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release , 1996, Science.

[37]  R. Dean,et al.  Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide production. , 1994, The Biochemical journal.

[38]  J. Garcia-Rubira,et al.  Anorexia nervosa and myocardial infarction. , 1994, International journal of cardiology.

[39]  R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[40]  J. Dawes,et al.  Effects of Heparin and Endothelial Cell Growth Supplement on Haemostatic Functions of Vascular Endothelium , 1992, Thrombosis and Haemostasis.

[41]  M. Laakso,et al.  Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. , 1990, The Journal of clinical investigation.

[42]  K. Park,et al.  Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. , 2004, The Journal of clinical endocrinology and metabolism.

[43]  T. Yoshikawa,et al.  Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[44]  S. O’Rahilly,et al.  Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. , 2003, The Journal of clinical endocrinology and metabolism.

[45]  M. Nakazato,et al.  Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. , 2002, The Journal of clinical endocrinology and metabolism.

[46]  A. Davenport,et al.  [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. , 2001, British journal of pharmacology.

[47]  D. Loskutoff,et al.  The prothrombotic effects of leptin possible implications for the risk of cardiovascular disease in obesity. , 2001, Annals of the New York Academy of Sciences.

[48]  R. Krauss,et al.  American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. , 1998, Circulation.

[49]  F A Mathewson,et al.  Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: the Manitoba Study. , 1977, The American journal of cardiology.