IN earlier communications1,2 two of us have described the œstrogenic activity of certain derivatives of diphenylethane, and in particular it was shown that the introduction of an ethylene linkage between the α and β carbon-atoms of such compounds greatly increased the potency. A number of stilbene derivatives were found to possess a marked activity. Following up this observation, the activity of p-hydroxypropylbenzene was next investigated and compared with that of p-hydroxypropenylbenzene (anol). The œstrogenic activity of some specimens of anol was found to be of a very high order, but further research indicated that this remarkable potency was probably due to the presence of a more complex substance produced as a by-product during the demethylation of anethole3. Recently, the activity of di-anol has been described4.
[1]
E. Dodds,et al.
Œstrogenic Activity of p-Hydroxy Propenyl Benzene (Anol)
,
1937,
Nature.
[2]
E. Dodds,et al.
A Simple Aromatic (Œstrogenic Agent with an Activity of the Same Order as that of Œstrone
,
1937,
Nature.
[3]
W. Lawson,et al.
Æstrogenic Activity of some Hydrocarbon Derivatives of Ethylene
,
1937,
Nature.
[4]
E. Dodds,et al.
Observations on the standardization of the water‐soluble, œstrus‐producing hormone
,
1930,
The Journal of physiology.