The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation.
暂无分享,去创建一个
D. Weiner | J. L. Hansen | S. Haunsø | E. Burstein | S. Sheikh | M. Aplin | M. M. Bonde | J. T. Hansen | G. L. Christensen | Mikael Schneider | H. Schiffer
[1] Robert J. Lefkowitz,et al. β-Arrestin-biased Agonism at the β2-Adrenergic Receptor* , 2008, Journal of Biological Chemistry.
[2] T. Schwartz,et al. Characterization of G-Protein Coupled Receptor Kinase Interaction with the Neurokinin-1 Receptor Using Bioluminescence Resonance Energy Transfer , 2008, Molecular Pharmacology.
[3] L. Hunyady,et al. AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells. , 2007, Biochemical pharmacology.
[4] S. Gammeltoft,et al. Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes. , 2007, Basic & clinical pharmacology & toxicology.
[5] S. Gammeltoft,et al. The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts. , 2007, Basic & clinical pharmacology & toxicology.
[6] C. Nakaie,et al. The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure. , 2007, Physiological reviews.
[7] R. Gainetdinov,et al. Physiological roles of G protein-coupled receptor kinases and arrestins. , 2007, Annual review of physiology.
[8] R. Lefkowitz,et al. β-Arrestins and Cell Signaling , 2007 .
[9] J. L. Hansen,et al. Cardiac regeneration by resident stem and progenitor cells in the adult heart , 2007, Basic Research in Cardiology.
[10] Arthur Christopoulos,et al. Functional Selectivity and Classical Concepts of Quantitative Pharmacology , 2007, Journal of Pharmacology and Experimental Therapeutics.
[11] M. Bouvier,et al. Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy , 2006, Molecular Pharmacology.
[12] J. Violin,et al. β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes , 2006, Proceedings of the National Academy of Sciences.
[13] S. Fluharty,et al. Identification of structural determinants for G protein-independent activation of mitogen-activated protein kinases in the seventh transmembrane domain of the angiotensin II type 1 receptor. , 2006, Molecular endocrinology.
[14] I. Komuro,et al. Molecular Mechanism Underlying Inverse Agonist of Angiotensin II Type 1 Receptor* , 2006, Journal of Biological Chemistry.
[15] D. Weiner,et al. Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout. , 2006, Current pharmaceutical design.
[16] John W. Adams,et al. Gαq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Gαq mediated hypertrophy , 2006 .
[17] U. Hacksell,et al. Intrinsic Efficacy of Antipsychotics at Human D2, D3, and D4 Dopamine Receptors: Identification of the Clozapine Metabolite N-Desmethylclozapine as a D2/D3 Partial Agonist , 2005, Journal of Pharmacology and Experimental Therapeutics.
[18] D. Roden,et al. Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice , 2005 .
[19] T. Kenakin. New Concepts in Drug Discovery: Collateral Efficacy and Permissive Antagonism , 2005, Nature Reviews Drug Discovery.
[20] C. Indolfi,et al. Cardiac stem and progenitor cell biology for regenerative medicine. , 2005, Trends in cardiovascular medicine.
[21] T. Sotnikova,et al. An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior , 2005, Cell.
[22] S. Yusuf,et al. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. , 2005, Journal of the American College of Cardiology.
[23] Robert J. Lefkowitz,et al. Transduction of Receptor Signals by ß-Arrestins , 2005, Science.
[24] J. Violin,et al. β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis , 2005, Molecular Pharmacology.
[25] R. Lefkowitz,et al. Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2* , 2004, Journal of Biological Chemistry.
[26] M. Caron,et al. ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway , 2004, Science.
[27] M. Bouvier,et al. Receptor activity‐independent recruitment of βarrestin2 reveals specific signalling modes , 2004, The EMBO journal.
[28] R. Lefkowitz,et al. Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor* , 2004, Journal of Biological Chemistry.
[29] J. L. Hansen,et al. Oligomerization of Wild Type and Nonfunctional Mutant Angiotensin II Type I Receptors Inhibits Gαq Protein Signaling but Not ERK Activation* , 2004, Journal of Biological Chemistry.
[30] D. Weiner,et al. Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor. , 2004, Molecular pharmacology.
[31] R. Lefkowitz,et al. Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by β-Arrestins 1 and 2* , 2004, Journal of Biological Chemistry.
[32] Pascale G. Charest,et al. β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[33] L. Hunyady,et al. Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[34] S. Fluharty,et al. Structural determinants for the activation mechanism of the angiotensin II type 1 receptor differ for phosphoinositide hydrolysis and mitogen-activated protein kinase pathways. , 2003, Biochemical pharmacology.
[35] L. Hunyady,et al. Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptors. , 2003, Biochemical pharmacology.
[36] M. Caron,et al. The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation* , 2003, The Journal of Biological Chemistry.
[37] L. Hunyady,et al. Agonist induction and conformational selection during activation of a G-protein-coupled receptor. , 2003, Trends in pharmacological sciences.
[38] Y. Hagiwara,et al. Mechanical stretch-induced mitogen-activated protein kinase activation is mediated via angiotensin and endothelin systems in vascular smooth muscle cells. , 2002, Biological & pharmaceutical bulletin.
[39] Hans Bräuner-Osborne,et al. Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). , 2002, European journal of biochemistry.
[40] David A. Calhoun,et al. Drugs targeting the renin–angiotensin–aldosterone system , 2002, Nature Reviews Drug Discovery.
[41] T. Kubo,et al. Altered Mitogen‐Activated Protein Kinase Activation In Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats , 2002, Clinical and experimental pharmacology & physiology.
[42] S. Haunsø,et al. Extracellular signal‐regulated kinases control expression of G protein‐coupled receptor kinase 2 (GRK2) , 2002, FEBS letters.
[43] M. Lew,et al. Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. , 2002, Molecular pharmacology.
[44] R. Lefkowitz,et al. β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation* , 2002, The Journal of Biological Chemistry.
[45] R. Neubig,et al. AT1 Receptor Mutant Lacking Heterotrimeric G Protein Coupling Activates the Src-Ras-ERK Pathway without Nuclear Translocation of ERKs* , 2002, The Journal of Biological Chemistry.
[46] P. Corvol,et al. Constitutive Internalization of Constitutively Active Angiotensin II AT1A Receptor Mutants Is Blocked by Inverse Agonists* , 2002, The Journal of Biological Chemistry.
[47] M A Geyer,et al. 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics. , 2001, The Journal of pharmacology and experimental therapeutics.
[48] S. Mundell,et al. Arrestin Specificity for G Protein-coupled Receptors in Human Airway Smooth Muscle* 210 , 2001, The Journal of Biological Chemistry.
[49] T. Baranski,et al. Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation. , 2000, Circulation research.
[50] S. Miura,et al. Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition. , 1999, Journal of hypertension.
[51] B. Maigret,et al. Mutation of Asn111 in the Third Transmembrane Domain of the AT1A Angiotensin II Receptor Induces Its Constitutive Activation* , 1997, The Journal of Biological Chemistry.
[52] T. Nanevicz,et al. Thrombin Receptor Activating Mutations , 1996, The Journal of Biological Chemistry.
[53] M. Brann,et al. Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells. , 1996, European journal of pharmacology.
[54] B. Maigret,et al. Amino acids of the third transmembrane domain of the AT1A angiotensin II receptor are involved in the differential recognition of peptide and nonpeptide ligands. , 1995, Biochemical and biophysical research communications.
[55] T. Yanase,et al. Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. , 1992, Biochemical and biophysical research communications.
[56] I. Sen,et al. Solubilization and characterization of an angiotensin II binding protein from liver. , 1983, European journal of biochemistry.
[57] E. Schiffrin,et al. Brain receptor binding and central actions of angiotensin analogs in rats. , 1981, The American journal of physiology.
[58] M. Sasamata,et al. Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers. , 2005, International journal of clinical pharmacology research.