3D Printing of Pharmaceuticals and Drug Delivery Devices

The process of 3D printing (3DP) was patented in 1986; however, the research in the field of 3DP did not become popular until the last decade. There has been an increasing research into the areas of 3DP for medical applications for fabricating prosthetics, bioprinting and pharmaceutics. This novel method allows the manufacture of dosage forms on demand, with modifications in the geometry and size resulting in changes to the release and dosage behaviour of the product. 3DP will allow wider adoption of personalised medicine due to the diversity and simplicity to change the design and dosage of the products, allowing the devices to be designed specific to the individual with the ability to alternate the drugs added to the product. Personalisation also has the potential to decrease the common side effects associated with generic dosage forms. This Special Issue Editorial outlines the current innovative research surrounding the topic of 3DP, focusing on bioprinting and various types of 3DP on applications for drug delivery as well advantages and future directions in this field of research.

[1]  D. Sohn,et al.  Customized Novel Design of 3D Printed Pregabalin Tablets for Intra-Gastric Floating and Controlled Release Using Fused Deposition Modeling , 2019, Pharmaceutics.

[2]  Eneko Larrañeta,et al.  Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing , 2020, Pharmaceutics.

[3]  Niklas Sandler,et al.  Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs , 2020, Pharmaceutics.

[4]  Pierre P. D. Kondiah,et al.  A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering , 2020, Pharmaceutics.

[5]  Suet Li Chew,et al.  3D-Printed Solid Dispersion Drug Products , 2019, Pharmaceutics.

[6]  Md Shahadat Hossain,et al.  Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective , 2020, Pharmaceutics.

[7]  Sheng Qi,et al.  Impact of Processing Parameters on the Quality of Pharmaceutical Solid Dosage Forms Produced by Fused Deposition Modeling (FDM) , 2019, Pharmaceutics.

[8]  Andrew V. Healy,et al.  Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography , 2019, Pharmaceutics.

[9]  Yu Huang,et al.  Application of Micro-Scale 3D Printing in Pharmaceutics , 2019, Pharmaceutics.

[10]  Niklas Sandler,et al.  Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets , 2019, Pharmaceutics.

[11]  S. Bandari,et al.  Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing , 2020, Pharmaceutics.

[12]  Jun-Bom Park,et al.  Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling , 2020, Pharmaceutics.

[13]  Adrienn Kazsoki,et al.  Fused Deposition Modeling 3D Printing: Test Platforms for Evaluating Post-Fabrication Chemical Modifications and In-Vitro Biological Properties , 2019, Pharmaceutics.

[14]  M. L. Fong,et al.  Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications , 2019, Pharmaceutics.

[15]  Katarzyna Rycerz,et al.  Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics , 2019, Pharmaceutics.

[16]  S. Ibrić,et al.  Optimization and Prediction of Ibuprofen Release from 3D DLP Printlets Using Artificial Neural Networks , 2019, Pharmaceutics.

[17]  Simon Gaisford,et al.  3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology , 2019, Pharmaceutics.

[18]  A. Kwade,et al.  Influence of High, Disperse API Load on Properties along the Fused-Layer Modeling Process Chain of Solid Dosage Forms , 2019, Pharmaceutics.

[19]  D. Fatouros,et al.  Development of Bio-Active Patches Based on Pectin for the Treatment of Ulcers and Wounds Using 3D-Bioprinting Technology , 2020, Pharmaceutics.

[20]  Tais Gratieri,et al.  The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality , 2019, Pharmaceutics.

[21]  Eneko Larrañeta,et al.  3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery , 2020, Pharmaceutics.

[22]  Simon Gaisford,et al.  3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method , 2019, Pharmaceutics.