Synthesis, characterisation and supramolecular interaction of Rh-biphenylic-imidazole-phenanthroline with antibiotics

A novel rhodium biphenylic imidazole phenanthroline metal-organic complex (BIP-MC) has been synthesised and characterised as a stable supramolecule. The structure of compound was established on the basis ESI, 1H NMR and UV–vis spectroscopic data. The selectivity of BIP-MC as a new fluorescent chemosensor for various antibiotics has been explored. The supramolecular interaction of amoxicillin with BIP-MC enhanced the fluorescence activity of BIP-MC. A linear response of the sensor was observed in the measuring ranges of excitation 240–298 nm and emission 290–360 nm with detection limits of up to 10 μg/ml at an optimum pH 8.0. Based on the observations made here, a new quantitative method for the determination of this drug in synthetic samples without the use of separation of matrix is developed. It is also inferred that the possible fluorescence enhancement is due to the formation of exciplex between the BIP-MC and amoxicillin. These finding will thus help in pharmacokinetics studies of drugs. The sensor was used for the direct assay of amoxicillin antibiotic in commercial pharmaceutical preparations.

[1]  J. Raoof,et al.  A novel voltammetric sensor for amoxicillin based on nickel-curcumin complex modified carbon paste electrode. , 2012, Bioelectrochemistry.

[2]  I. Hamdan,et al.  CAPILLARY ELECTROPHORESIS WITH ELECTROKINETIC INJECTION SIMPLIFIES THE DISSOLUTION TESTING OF AMOXICILLIN CAPSULES , 2012 .

[3]  A. Vázquez,et al.  Simultaneous Determination of Bromhexine and Amoxicillin in Pharmaceutical Formulations by Capillary Electrophoresis , 2011 .

[4]  K. Jolliffe,et al.  Hybrid cyclic peptide-thiourea cryptands for anion recognition. , 2011, Chemical communications.

[5]  M. Bergamini,et al.  Voltammetric sensor for amoxicillin determination in human urine using polyglutamic acid/glutaraldehyde film , 2008 .

[6]  A. Rajić,et al.  Antimicrobial resistance in generic Escherichia coli isolated from swine fecal samples in 90 Alberta finishing farms. , 2008, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[7]  Mercedes Crego-Calama,et al.  Design of fluorescent materials for chemical sensing. , 2007, Chemical Society reviews.

[8]  Quan-min Li,et al.  Study of Spectrophotometric Determination of Amoxicillin Using Sodium 1,2‐Naphthoquinone‐4‐Sulfonate as the Chemical Derivative Chromogenic Reagent , 2006 .

[9]  M. Q. Al-Abachi,et al.  Spectrophotometric determination of amoxicillin by reaction with N,N-dimethyl-p-phenylenediamine and potassium hexacyanoferrate(III) , 2005 .

[10]  J. Tae,et al.  A rhodamine-based fluorescent and colorimetric chemodosimeter for the rapid detection of Hg2+ ions in aqueous media. , 2005, Journal of the American Chemical Society.

[11]  Michal Douša,et al.  Rapid determination of amoxicillin in premixes by HPLC. , 2005, Journal of pharmaceutical and biomedical analysis.

[12]  Yuhai Tang,et al.  Determination of ampicillin and amoxycillin by flow injection chemiluminescence method based on their enhancing effects on the luminol-periodate reaction. , 2003, Luminescence : the journal of biological and chemical luminescence.

[13]  T. Gunnlaugsson,et al.  Fluorescent sensing of pyrophosphate and bis-carboxylates with charge neutral PET chemosensors. , 2002, Organic letters.

[14]  T. Swager,et al.  Fluorescent Porous Polymer Films as TNT Chemosensors: Electronic and Structural Effects , 1998 .

[15]  J. Waluk,et al.  Solvent-Controlled Excited State Behavior: 2-(2‘-Pyridyl)indoles in Alcohols , 1996 .

[16]  G. Saleh.  Two selective spectrophotometric methods for the determination of amoxicillin and cefadroxil , 1996 .