Caffeine strengthens action monitoring: evidence from the error-related negativity.

The medial frontal cortex, especially the anterior cingulate cortex (ACC), is involved in action monitoring. We studied the role of moderate amounts of caffeine in action monitoring as expressed by the error-related negativity (ERN), an event-related brain component that reflects ACC activity. In a double-blind, placebo-controlled, within-subjects experiment, two caffeine doses (3 and 5 mg/kg body weight) and a placebo were administered to habitual coffee drinkers. Compared with placebo, both caffeine doses enlarged the ERN. Amplitudes of the P2 and P3 components were not affected by caffeine. Thus, the enlarged ERN after caffeine reflects a specific effect on action monitoring. We conclude that consumption of a few cups of coffee strengthens central information processing, specifically the monitoring of ongoing cognitive processes for signs of erroneous outcomes. Brain areas related to action monitoring such as the ACC presumably mediate these caffeine effects.

[1]  K. R. Ridderinkhof,et al.  Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task. , 2001, Psychophysiology.

[2]  M M Lorist,et al.  Caffeine effects on perceptual and motor processes. , 1997, Electroencephalography and clinical neurophysiology.

[3]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[4]  M. D. Ruiter,et al.  The influence of caffeine on spatial-selective attention: an event-related potential study , 2000, Clinical Neurophysiology.

[5]  C. Carter,et al.  The anterior cingulate as a conflict monitor: fMRI and ERP studies , 2002, Physiology & Behavior.

[6]  K. R. Ridderinkhof,et al.  A computational account of altered error processing in older age: Dopamine and the error-related negativity , 2002, Cognitive, affective & behavioral neuroscience.

[7]  J. Robinson,et al.  Caffeine antagonism of alcohol-induced driving impairment. , 2001, Drug and alcohol dependence.

[8]  Astrid Nehlig,et al.  Are we dependent upon coffee and caffeine? A review on human and animal data , 1999, Neuroscience & Biobehavioral Reviews.

[9]  A. Kok,et al.  Influence of caffeine on information processing stages in well rested and fatigued subjects , 2005, Psychopharmacology.

[10]  J. Hohnsbein,et al.  ERP components on reaction errors and their functional significance: a tutorial , 2000, Biological Psychology.

[11]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[12]  M J Eckardt,et al.  Effects of moderate alcohol consumption on the central nervous system. , 1998, Alcoholism: Clinical and Experimental Research.

[13]  R. Griffiths,et al.  The Role of Dopamine in the Behavioral Effects of Caffeine in Animals and Humans , 1997, Pharmacology Biochemistry and Behavior.

[14]  J. Snel,et al.  The effects of caffeine on visual selective attention to color: an ERP study. , 2000, Psychophysiology.

[15]  S. Nieuwenhuis,et al.  Mental fatigue and task control: planning and preparation. , 2000, Psychophysiology.

[16]  H. Lieberman,et al.  The effects of low doses of caffeine on human performance and mood , 2004, Psychopharmacology.

[17]  W. Hulstijn,et al.  Drug-induced stimulation and suppression of action monitoring in healthy volunteers , 2004, Psychopharmacology.

[18]  R. Thayer,et al.  Measurement of Activation through Self-Report , 1967, Psychological reports.

[19]  R. Näätänen,et al.  Adenosine A1/A2a receptors mediate suppression of mismatch negativity by ethanol in humans , 2000, Neuroscience Letters.

[20]  D. Meyer,et al.  A Neural System for Error Detection and Compensation , 1993 .

[21]  G. J. Mellenbergh,et al.  De verkorte versie van de Nederlandse vertaling van de Profile of Mood States (POMS). , 1990 .

[22]  J. Allman,et al.  The Anterior Cingulate Cortex , 2001, Annals of the New York Academy of Sciences.

[23]  J. C. Woestenburg,et al.  The removal of the eye-movement artifact from the EEG by regression analysis in the frequency domain , 1983, Biological Psychology.

[24]  Sergi Ferré,et al.  Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia , 1997, Trends in Neurosciences.

[25]  Clay B. Holroyd,et al.  The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. , 2002, Psychological review.

[26]  P. Rogers,et al.  Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence , 1998, Behavioural pharmacology.

[27]  A Kok,et al.  Acute effects of caffeine on selective attention and visual search processes. , 1996, Psychophysiology.

[28]  P. Rabbitt.  Errors and error correction in choice-response tasks. , 1966, Journal of experimental psychology.

[29]  M. Fillmore,et al.  Dissociative antagonistic effects of caffeine on alcohol-induced impairment of behavioral control. , 2003, Experimental and clinical psychopharmacology.

[30]  B. Fredholm,et al.  Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. , 1999, Pharmacological reviews.

[31]  D. Tucker,et al.  Medial Frontal Cortex in Action Monitoring , 2000, The Journal of Neuroscience.

[32]  D. V. Cramon,et al.  Subprocesses of Performance Monitoring: A Dissociation of Error Processing and Response Competition Revealed by Event-Related fMRI and ERPs , 2001, NeuroImage.

[33]  G. Chiara,et al.  Differential Effects of Caffeine on Dopamine and Acetylcholine Transmission in Brain Areas of Drug-naive and Caffeine-pretreated Rats , 2002, Neuropsychopharmacology.

[34]  K. Richard Ridderinkhof,et al.  Alcohol Consumption Impairs Detection of Performance Errors in Mediofrontal Cortex , 2002, Science.

[35]  J. Hohnsbein,et al.  Effects of crossmodal divided attention on late ERP components. II. Error processing in choice reaction tasks. , 1991, Electroencephalography and clinical neurophysiology.

[36]  Astrid Nehlig,et al.  Dose–response study of caffeine effects on cerebral functional activity with a specific focus on dependence , 2000, Brain Research.

[37]  M. Schmitter-Edgecombe,et al.  Costs of a predictable switch between simple cognitive tasks following severe closed-head injury. , 2006, Neuropsychology.

[38]  C. Drake,et al.  Caffeine Reversal of Ethanol Effects on the Multiple Sleep Latency Test, Memory, and Psychomotor Performance , 2003, Neuropsychopharmacology.