Environmental analysis of fluorinated alkyl substances by liquid chromatography–(tandem) mass spectrometry: a review

Fluorinated alkyl substances (FASs) are widely distributed contaminants that have been found in many environmental, human and biological samples throughout the world. Perfluorochemicals are used in many industry and consumer products, such as polymers and surfactants, because they have unique and useful properties (they are stable, chemically inert and generally unreactive). However, these compounds have also been found to be toxic, persistent and bioaccumulative. In recent years various analytical methods have been developed for the analysis of FASs in environmental samples. Most of these methods are based on liquid chromatography coupled to mass spectrometry (LC–MS) or tandem mass spectrometry (LC–MS/MS), since this is considered to be the technique of choice. This article reviews the various LC–(tandem)MS methods described so far for the analysis of FASs in water, sediment, sludge and biota samples. It discusses the main experimental conditions used for sample pretreatment and for analysis as well as the most relevant problems encountered and the limits of detection achieved.

[1]  J. Westall,et al.  Sorption of linear alkylbenzenesulfonates on sediment materials , 1999 .

[2]  D F Hagen,et al.  Characterization of fluorinated metabolites by a gas chromatographic-helium microwave plasma detector--the biotransformation of 1H, 1H, 2H, 2H-perfluorodecanol to perfluorooctanoate. , 1981, Analytical biochemistry.

[3]  Jerald L Schnoor,et al.  Mass budget of perfluorooctane surfactants in Lake Ontario. , 2005, Environmental science & technology.

[4]  Scott A Mabury,et al.  Monitoring perfluorinated surfactants in biota and surface water samples following an accidental release of fire-fighting foam into Etobicoke Creek. , 2002, Environmental science & technology.

[5]  John P Giesy,et al.  Concentrations of perfluorinated acids in livers of birds from Japan and Korea. , 2002, Chemosphere.

[6]  E. Kissa,et al.  Fluorinated Surfactants and Repellents , 2001 .

[7]  D F Hagen,et al.  A method for the determination of perfluorooctanoic acid in blood and other biological samples. , 1980, Analytical biochemistry.

[8]  E. Kissa.  Fluorinated surfactants : synthesis, properties, applications , 1994 .

[9]  Fumio Okada,et al.  Determination of perfluorooctane sulfonate, perfluorooctanoate and perfluorooctane sulfonylamide in human plasma by column-switching liquid chromatography-electrospray mass spectrometry coupled with solid-phase extraction. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  Jerald L Schnoor,et al.  Detection of perfluorooctane surfactants in Great Lakes water. , 2004, Environmental science & technology.

[11]  Lennart Hardell,et al.  Development of a solid-phase extraction-HPLC/single quadrupole MS method for quantification of perfluorochemicals in whole blood. , 2005, Analytical chemistry.

[12]  U. Brinkman,et al.  Solid-phase extraction of polar pesticides from environmental water samples on graphitized carbon and Empore-activated carbon disks and on-line coupling to octadecyl-bonded silica analytical columns. , 1996, Journal of chromatography. A.

[13]  Pim de Voogt,et al.  Environmental and toxicity effects of perfluoroalkylated substances. , 2003, Reviews of environmental contamination and toxicology.

[14]  Tsuyoshi Okazawa,et al.  Analysis of fluorotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota. , 2005, Journal of chromatography. A.

[15]  D. Kuehl,et al.  Chromatographic and mass spectral studies of perfluorooctanesulfonate and three perfluorooctanesulfonamides. , 2003, Rapid communications in mass spectrometry : RCM.

[16]  J. Giesy,et al.  Global distribution of perfluorooctane sulfonate in wildlife. , 2001, Environmental science & technology.

[17]  C. Minoia,et al.  Quantitative determination of perfluorooctanoic acid ammonium salt in human serum by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. , 2002, Rapid communications in mass spectrometry : RCM.

[18]  John P. Giesy,et al.  Perfluorooctane Sulfonate in Oysters, Crassostrea virginica, from the Gulf of Mexico and the Chesapeake Bay, USA , 2002, Archives of Environmental Contamination and Toxicology.

[19]  Jennifer A Field,et al.  Quantitative determination of fluorinated alkyl substances by large-volume-injection liquid chromatography tandem mass spectrometry-characterization of municipal wastewaters. , 2006, Environmental science & technology.

[20]  Jeffrey H Mandel,et al.  Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly population from Seattle, Washington. , 2004, Chemosphere.

[21]  K. Hansen,et al.  Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices. , 2001, Environmental science & technology.

[22]  Takahide Kimura,et al.  Distribution and forms of fluorine in whole blood of human male. , 1989, Analytical biochemistry.

[23]  Wenyue Hu,et al.  Binding of perfluorinated fatty acids to serum proteins , 2003, Environmental toxicology and chemistry.

[24]  T. Wallington,et al.  Atmospheric lifetime of fluorotelomer alcohols. , 2003, Environmental science & technology.

[25]  Scott A Mabury,et al.  Polyfluorinated telomer alcohols and sulfonamides in the North American troposphere. , 2004, Environmental science & technology.

[26]  Craig S. Criddle,et al.  Fluorinated Organics in the Biosphere , 1997 .

[27]  Jennifer A. Field,et al.  Determination of perfluorocarboxylates in groundwater impacted by fire-fighting activity , 1999 .

[28]  Nobuyoshi Yamashita,et al.  A survey of perfluorooctane sulfonate and related perfluorinated organic compounds in water, fish, birds, and humans from Japan. , 2003, Environmental science & technology.

[29]  Tyge Greibrokk,et al.  Determination of perfluorooctane sulfonate and perfluorooctanoic acid in human plasma by large volume injection capillary column switching liquid chromatography coupled to electrospray ionization mass spectrometry. , 2004, Journal of separation science.

[30]  F. Nakata,et al.  High-performance liquid chromatography with conductimetric detection of perfluorocarboxylic acids and perfluorosulfonates. , 2004, Chemosphere.

[31]  T. Nakahara,et al.  Determination of perfluorooctane sulfonate in river water by liquid chromatography/atmospheric pressure photoionization mass spectrometry by automated on-line extraction using turbulent flow chromatography. , 2003, Rapid communications in mass spectrometry : RCM.

[32]  A. Calafat,et al.  Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk. , 2004, Environmental science & technology.

[33]  Kouji Harada,et al.  Perfluorooctanoate and Perfluorooctane Sulfonate Concentrations in Surface Water in Japan , 2004, Journal of occupational health.

[34]  H. Schröder,et al.  Determination of fluorinated surfactants and their metabolites in sewage sludge samples by liquid chromatography with mass spectrometry and tandem mass spectrometry after pressurised liquid extraction and separation on fluorine-modified reversed-phase sorbents. , 2003, Journal of chromatography. A.

[35]  Jennifer A. Field,et al.  Perfluorinated Surfactants and the Environmental Implications of Their Use in Fire-Fighting Foams , 2000 .

[36]  Paul D. Jones,et al.  Perfluorooctane sulfonate in fish-eating water birds including bald eagles and albatrosses. , 2001, Environmental science & technology.

[37]  Jennifer A. Field,et al.  Fluorinated Alkyl Surfactants , 2003 .

[38]  Method for the Determination of Perfluorooctanoic Acid in Air Samples Using Liquid Chromatography with Mass Spectrometry , 2005, Journal of occupational and environmental hygiene.

[39]  E. Braekevelt,et al.  Biotransformation of N-ethyl perfluorooctanesulfonamide by rainbow trout (Onchorhynchus mykiss) liver microsomes. , 2004, Environmental science & technology.

[40]  Attila E. Pavlath,et al.  Chemistry of organic fluorine compounds II : a critical review , 1995 .

[41]  John P Giesy,et al.  Perfluorooctanesulfonate and related fluorinated hydrocarbons in mink and river otters from the United States. , 2002, Environmental science & technology.

[42]  Scott A Mabury,et al.  Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids. , 2004, Environmental science & technology.

[43]  Jennifer A Field,et al.  Quantitative determination of fluorotelomer sulfonates in groundwater by LC MS/MS. , 2004, Environmental science & technology.

[44]  Scott A Mabury,et al.  Collection of airborne fluorinated organics and analysis by gas chromatography/chemical ionization mass spectrometry. , 2002, Analytical chemistry.

[45]  Fumio Okada,et al.  Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Maternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy , 2004, Environmental health perspectives.

[46]  Hans-Joachim Lehmler,et al.  Synthesis of environmentally relevant fluorinated surfactants--a review. , 2005, Chemosphere.

[47]  Tsuyoshi Okazawa,et al.  Analysis of perfluorinated acids at parts-per-quadrillion levels in seawater using liquid chromatography-tandem mass spectrometry. , 2004, Environmental science & technology.

[48]  A. Koizumi,et al.  Perfluorooctane Sulfonate Concentrations in Surface Water in Japan , 2003, Archives of environmental contamination and toxicology.

[49]  Jeffrey H Mandel,et al.  Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals. , 2003, Environmental science & technology.

[50]  S. D. Cunningham,et al.  SEQUESTRATION OF HYDROPHOBIC ORGANIC CONTAMINANTS BY GEOSORBENTS , 1997 .

[51]  K. Tanaka,et al.  Separation of perfluoroalkylsulfinic acids and perfluoroalkylsulfonic acids by ion-exclusion chromatography. , 2001, Journal of chromatography. A.

[52]  N Yamashita,et al.  Perfluorinated compounds in coastal waters of Hong Kong, South China, and Korea. , 2004, Environmental science & technology.

[53]  Feiyue Wang,et al.  Fluorotelomer carboxylic acids and PFOS in rainwater from an urban center in Canada. , 2005, Environmental science & technology.

[54]  J. S. Eldridge,et al.  Quantitative characterization of trace levels of PFOS and PFOA in the Tennessee River. , 2002, Environmental science & technology.

[55]  N. Kudo,et al.  Determination of perfluorinated carboxylic acids in biological samples by high-performance liquid chromatography. , 1998, Journal of chromatography. B, Biomedical sciences and applications.

[56]  Timothy J Wallington,et al.  Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids. , 2004, Environmental science & technology.

[57]  Paul D. Jones,et al.  Accumulation of perfluorooctane sulfonate in marine mammals. , 2001, Environmental science & technology.

[58]  C. Criddle,et al.  Quantitative determination of perfluorochemicals in sediments and domestic sludge. , 2005, Environmental science & technology.

[59]  D. Barceló,et al.  On-line solid-phase extraction-ion-pair liquid chromatography-electrospray mass spectrometry for the trace determination of naphthalene monosulphonates in water. , 1999, Journal of chromatography. A.

[60]  Jerald L Schnoor,et al.  Evaluation of perfluorooctane surfactants in a wastewater treatment system and in a commercial surface protection product. , 2005, Environmental science & technology.

[61]  S. Mabury,et al.  Determination of perfluorinated surfactants in surface water samples by two independent analytical techniques: liquid chromatography/tandem mass spectrometry and 19F NMR. , 2001, Analytical chemistry.

[62]  Pim de Voogt,et al.  Analytical chemistry of perfluoroalkylated substances , 2006 .

[63]  K. Tanaka,et al.  Novel way of separating polyfluorocarboxylic acids by ion-exclusion chromatography. , 2000, Journal of Chromatography A.