Hemodynamics of Collateral Vasodilatation following Femoral Artery Occlusion in Anesthetized Dogs

Dilatation of collateral blood vessels was studied following occlusion of the femoral artery in anesthetized dogs. This was achieved by measuring pressure and flow in the anterior tibial artery distal to the occlusion and pressure in the femoral artery proximal to the occlusion. Dilatation of the collateral vessels to the anterior tibial artery was estimated by the increase in the conductance of the collaterals from the minimum value measured 8 to 10 seconds following onset of the occlusion. Conductance rose 277 ± 67 (SEM)% during the first 70 seconds following occlusion and an additional 178 ± 66% during the ensuing hour. When the femoral artery was reopened after a 2-minute period of occlusion, the collaterals reconstricted to their preocclusion size in 12 to 14 minutes. Elimination of circulatory reflexes by total spinal anesthesia did not alter the course of collateral vasodilatation. However, when systemic arterial pressure was lowered to approximately 45 mm Hg for 8 minutes prior to occlusion, the collaterals dilated almost completely even before the occlusion was instituted, indicating that tissue ischemia is in some way related to collateral vasodilatation.

[1]  J. T. Shepherd.  The effect of acute occlusion of the femoral artery on the blood supply to the calf of the leg before and after release of sympathetic vasomotor tone. , 1950, Clinical science.

[2]  L. Laville,et al.  Etiologic mechanisms in the development of collateral circulation. , 1959, Surgery.

[3]  R. W. Eckstein,et al.  THE MAGNITUDE AND TIME OF DEVELOPMENT OF THE COLLATERAL CIRCULATION IN OCCLUDED FEMORAL, CAROTID AND CORONARY ARTERIES , 1941 .

[4]  A. C. Guyton,et al.  Constant infusion of epinephrine; rate of epinephrine secretion and destruction in the body. , 1951, The American journal of physiology.

[5]  S. Hilton.  A peripheral arterial conducting mechanism underlying dilatation of the femoral artery and concerned in functional vasodilatation in skeletal muscle , 1959, The Journal of physiology.

[6]  W. Bayliss.  On the local reactions of the arterial wall to changes of internal pressure , 1902, The Journal of physiology.

[7]  A. Koch.  SOME MATHEMATICAL FORMS OF AUTOREGULATORY MODELS. , 1964, Circulation research.

[8]  A. Melville.  Pressure measurement in the human organism. , 1953, The New Zealand medical journal.

[9]  D. P. Quiring.  Collateral circulation (anatomical aspects) , 1949 .

[10]  Shepherd Jt.  The effect of acute occlusion of the femoral artery on the blood supply to the calf of the leg before and after release of sympathetic vasomotor tone. , 1950 .

[11]  Johnson Pc.  REVIEW OF PREVIOUS STUDIES AND CURRENT THEORIES OF AUTOREGULATION. , 1964 .

[12]  Longland Cj.  The collateral circulation of the limb; Arris and Gale lecture delivered at the Royal College of Surgeons of England on 4th February, 1953. , 1953 .

[13]  P. Johnson.  REVIEW OF PREVIOUS STUDIES AND CURRENT THEORIES OF AUTOREGULATION. , 1964, Circulation research.

[14]  J. Walker,et al.  EVIDENCE FOR TISSUE OXYGEN DEMAND AS THE MAJOR FACTOR CAUSING AUTOREGULATION. , 1964, Circulation research.

[15]  H. T. John,et al.  The stimulus to collateral circulation. , 1961, Surgery.

[16]  E. Nyman,et al.  “Adrenergic Blocking” Substances (Quaternary Derivatives of N,N‐Dibenzyl‐β‐Chloroethylamine) , 1949 .

[17]  S. Bevegård.  Studies on the regulation of the circulation in man. With special reference to the stroke volume and the effect of muscular work, body position and artificially induced variations of the heart rate. , 1962, Acta physiologica Scandinavica. Supplementum.

[18]  J. Flasher,et al.  Sympathetic Denervation in the Treatment of Acute Arterial Occlusion , 1954, Circulation.

[19]  S. Harvey,et al.  The Mechanism of the Development of Collateral Circulation , 1931 .

[20]  C. Longland.  Collateral Circulation in the Limb , 1953, Postgraduate medical journal.

[21]  G. Herrold,et al.  Experience with a new electro-magnetic flow-meter for use in blood-flow determinations in surgery. , 1960, Annals of surgery.

[22]  R. Lasser,et al.  Production of Chronic Elevation of Left Ventricular End Diastolic Pressure in Dogs: Hemodynamic and Renal Studies , 1964, Circulation research.

[23]  J. Walker,et al.  ROLE OF OXYGEN IN AUTOREGULATION OF BLOOD FLOW IN ISOLATED VESSELS. , 1964, The American journal of physiology.