Analysis of an SVEIS epidemic model with partial temporary immunity and saturation incidence rate

Abstract In this paper, an SVEIS epidemic model for an infectious disease that spreads in the host population through horizontal transmission is investigated. The role that temporary immunity (natural, disease induced, vaccination induced) plays in the spread of disease, is incorporated in the model. The total host population is bounded and the incidence term is of the Holling-type II form. It is shown that the model exhibits two equilibria, namely, the disease-free equilibrium and the endemic equilibrium. The global dynamics are completely determined by the basic reproduction number R 0 . If R 0 1 , the disease-free equilibrium is globally stable which leads to the eradication of disease from population. If R 0 > 1 , a unique endemic equilibrium exists and is globally stable in the feasible region under certain conditions. Further, the transcritical bifurcation at R 0 = 1 is explored by projecting the flow onto the extended center manifold. We use the geometric approach for ordinary differential equations which is based on the use of higher-order generalization of Bendixson’s criterion. Further, we obtain the threshold vaccination coverage required to eradicate the disease. Finally, taking biologically relevant parametric values, numerical simulations are performed to illustrate and verify the analytical results.

[1]  Xuezhi Li,et al.  Global dynamics of a mathematical model for HTLV-I infection of CD4+ T-cells☆ , 2011 .

[2]  G. Serio,et al.  A generalization of the Kermack-McKendrick deterministic epidemic model☆ , 1978 .

[3]  Thomas W Carr,et al.  An SIR epidemic model with partial temporary immunity modeled with delay , 2009, Journal of mathematical biology.

[4]  Xueyong Zhou,et al.  Analysis of stability and bifurcation for an SEIV epidemic model with vaccination and nonlinear incidence rate , 2011 .

[5]  Mini Ghosh,et al.  Global stability of a stage-structured epidemic model with a nonlinear incidence , 2009, Appl. Math. Comput..

[6]  Christopher T. McCaw,et al.  A Biological Model for Influenza Transmission: Pandemic Planning Implications of Asymptomatic Infection and Immunity , 2007, PloS one.

[7]  C. Castillo-Chavez,et al.  Mathematical Approaches for Emerging and Reemerging Infectious Diseases: An Introduction , 2002 .

[8]  Herbert W. Hethcote,et al.  The Mathematics of Infectious Diseases , 2000, SIAM Rev..

[9]  P van den Driessche,et al.  Two SIS epidemiologic models with delays , 2000, Journal of mathematical biology.

[10]  Yuliya N. Kyrychko,et al.  Stability and Bifurcations in an Epidemic Model with Varying Immunity Period , 2012, Bulletin of mathematical biology.

[11]  James S. Muldowney,et al.  Compound matrices and ordinary differential equations , 1990 .

[12]  Hal L. Smith,et al.  Asymptotically autonomous semiflows: chain recurrence and Lyapunov functions , 1995 .

[13]  I. Julkunen,et al.  Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination. , 2007, The Journal of infectious diseases.

[14]  James S. Muldowney,et al.  On R.A. Smith's Autonomous Convergence Theorem , 1995 .

[15]  Shigui Ruan,et al.  Uniform persistence and flows near a closed positively invariant set , 1994 .

[16]  Murray E. Alexander,et al.  Bifurcation Analysis of an SIRS Epidemic Model with Generalized Incidence , 2005, SIAM J. Appl. Math..

[17]  Jeremy M. Grimshaw,et al.  Increasing the demand for childhood vaccination in developing countries: a systematic review , 2009, BMC international health and human rights.

[18]  James S. Muldowney,et al.  A Geometric Approach to Global-Stability Problems , 1996 .

[19]  Edward M. Lungu,et al.  THE EFFECTS OF VACCINATION AND TREATMENT ON THE SPREAD OF HIV/AIDS , 2004 .

[20]  Deborah Lacitignola,et al.  On the dynamics of an SEIR epidemic model with a convex incidence rate , 2008 .

[21]  P. van Damme,et al.  Passive transmission and persistence of naturally acquired or vaccine-induced maternal antibodies against measles in newborns. , 2007, Vaccine.

[22]  Y. N. Kyrychko,et al.  Global properties of a delayed SIR model with temporary immunity and nonlinear incidence rate , 2005 .

[23]  Herbert W. Hethcote,et al.  An SIS epidemic model with variable population size and a delay , 1995, Journal of mathematical biology.

[24]  Umesh Parashar,et al.  Recent resurgence of mumps in the United States. , 2008, The New England journal of medicine.

[25]  J. Mossong,et al.  Modelling measles re-emergence as a result of waning of immunity in vaccinated populations. , 2003, Vaccine.

[26]  Michael Y. Li Dulac criteria for autonomous systems having an invariant affine manifold , 1996 .

[27]  Xue-Zhi Li,et al.  Analysis of a SEIV epidemic model with a nonlinear incidence rate , 2009 .

[28]  A. Sharma,et al.  The role of the incubation period in a disease model. , 2009 .

[29]  S. Twu,et al.  Waning immunity to plasma‐derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination , 2004, Hepatology.

[30]  Joydip Dhar,et al.  The role of viral infection in phytoplankton dynamics with the inclusion of incubation class , 2010 .

[31]  S. C. Mpeshe,et al.  Optimal Control and Sensitivity Analysis of an Influenza Model with Treatment and Vaccination , 2011, Acta biotheoretica.

[32]  K. L. Cooke,et al.  Analysis of an SEIRS epidemic model with two delays , 1996, Journal of mathematical biology.

[33]  Rui Xu,et al.  Global stability of a delayed SEIRS epidemic model with saturation incidence rate , 2010 .

[34]  Nicholas F Britton,et al.  Analysis of a Vector-Bias Model on Malaria Transmission , 2011, Bulletin of mathematical biology.

[35]  Robert H. Martin Logarithmic norms and projections applied to linear differential systems , 1974 .

[36]  G F Medley,et al.  Dynamical behaviour of epidemiological models with sub-optimal immunity and nonlinear incidence , 2005, Journal of mathematical biology.

[37]  K. Schmitt,et al.  Permanence and the dynamics of biological systems. , 1992, Mathematical biosciences.

[38]  P. Glendinning Stability, Instability and Chaos: An Introduction to the Theory of Nonlinear Differential Equations , 1994 .