Heavy metal ions in wines: meta-analysis of target hazard quotients reveal health risks

BackgroundMetal ions such as iron and copper are among the key nutrients that must be provided by dietary sources. Numerous foodstuffs have been evaluated for their contributions to the recommended daily allowance both to guide for satisfactory intake and also to prevent over exposure. In the case of heavy metal ions, the focus is often on exposure to potentially toxic levels of ions such as lead and mercury. The aim of this study is to determine target hazard quotients (THQ) from literature reports giving empirical levels of metal ions in table wines using the reference upper safe limit value. Contributions to the THQ value were calculated for seven metal ions along with total values for each wine.ResultsThe THQ values were determined as ranges from previously reported ranges of metal ion concentrations and were frequently concerningly high. Apart from the wines selected from Italy, Brazil and Argentina, all other wines exhibited THQ values significantly greater than one indicating levels of risk. The levels of vanadium, copper and manganese had the highest impact on THQ measures. Typical potential maximum THQ values ranged from 50 to 200 with Hungarian and Slovakian wines reaching 300. THQ values for a sample of red and white wines were high for both having values ranging from 30 to 80 for females based on a 250 mL glass per day.ConclusionThe THQ values calculated are concerning in that they are mainly above the safe level of THQ<1. It is notable that in the absence of upper safe limits, THQ values cannot be calculated for most metal ions, suggesting that further unaccountable risks are associated with intake of these wines.

[1]  M. Suchanek,et al.  Multivariate classification of wines from different bohemian regions (Czech Republic) , 2005 .

[2]  M. Valko,et al.  Free radicals, metals and antioxidants in oxidative stress-induced cancer. , 2006, Chemico-biological interactions.

[3]  B. Han,et al.  Analysis of the health risk of exposure to breast milk mercury in infants in Taiwan. , 2006, Chemosphere.

[4]  S. Catarino,et al.  Measurements of contaminant elements of wines by inductively coupled plasma-mass spectrometry: A comparison of two calibration approaches. , 2006, Talanta.

[5]  S. Flora,et al.  Arsenic and lead induced free radical generation and their reversibility following chelation. , 2007, Cellular and molecular biology.

[6]  T. Hung,et al.  Daily intake of TBT, Cu, Zn, Cd and As for fishermen in Taiwan. , 2002, The Science of the total environment.

[7]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .

[8]  S. Mandel,et al.  Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. , 2006, Molecular nutrition & food research.

[9]  Declan P Naughton,et al.  Dietary chelators as antioxidant enzyme mimetics: implications for dietary intervention in neurodegenerative diseases. , 2006, Behavioural pharmacology.

[10]  Madhavi Bajekal,et al.  Health Survey for England , 2004 .

[11]  Y. Hsueh,et al.  Assessing the human health risks from exposure of inorganic arsenic through oyster (Crassostrea gigas) consumption in Taiwan. , 2006, The Science of the total environment.

[12]  Qing-wei Yang,et al.  Heavy Metals of Vegetables and Soils of Vegetable Bases in Chongqing, Southwest China , 2007, Environmental monitoring and assessment.

[13]  W. Longstreth,et al.  Parkinson’s disease risks associated with dietary iron, manganese, and other nutrient intakes , 2003, Neurology.

[14]  Baoshan Xing,et al.  Health risks of heavy metals to the general public in Tianjin, China via consumption of vegetables and fish. , 2005, The Science of the total environment.

[15]  D. Naughton,et al.  Therapeutic chelators for the twenty first century: new treatments for iron and copper mediated inflammatory and neurological disorders. , 2005, Current drug delivery.

[16]  A. Petróczi,et al.  The metal ion theory of ageing: dietary target hazard quotients beyond radicals , 2008, Immunity & Ageing.

[17]  H J P Marvin,et al.  Early identification systems for emerging foodborne hazards. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[18]  A. Petróczi,et al.  Heavy metal ions in wines: meta-analysis of target hazard quotients reveal health risks , 2009, Chemistry Central Journal.

[19]  H J P Marvin,et al.  Identification of potentially emerging food safety issues by analysis of reports published by the European Community's Rapid Alert System for Food and Feed (RASFF) during a four-year period. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[20]  Na Zheng,et al.  Population health risk due to dietary intake of heavy metals in the industrial area of Huludao City, China. , 2007, The Science of the total environment.

[21]  Dh.  Health Survey for England 2002 - trends , 2004 .

[22]  Andrea Petróczi,et al.  Correction: Determination of metal ion content of beverages and estimation of target hazard quotients: a comparative study , 2008, Chemistry Central Journal.

[23]  N. Holbrook,et al.  Oxidants, oxidative stress and the biology of ageing , 2000, Nature.

[24]  P. Pohl,et al.  What do metals tell us about wine , 2007 .