Cycloferon as a Means for Prevention, Treatment, and Control of COVID-19: Multidisciplinary and Comparative Historical Aspects

The study of coronaviruses, including those capable of causing life-threatening diseases, continued for many decades. So did the study of interferons, as well as acridine acetic acid, which is a powerful interferon inducer. For a long time, both directions of research developed in parallel to each other. However, the discovery of SARS-CoV and the creation of Cycloferon based on acridine acetic acid made both research directions converge. To date, the abundance of factual and theoretical tenets is enough to estimate the potential effectiveness of acridine acetic acid against COVID-19.

[1]  L. Prokunina-Olsson,et al.  Weak Induction of Interferon Expression by SARS-CoV-2 Supports Clinical Trials of Interferon Lambda to Treat Early COVID-19. , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  L. Prokunina-Olsson,et al.  COVID-19 and emerging viral infections: The case for interferon lambda , 2020, The Journal of experimental medicine.

[3]  Dong-Yan Jin,et al.  A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses , 2020, Emerging microbes & infections.

[4]  S. Samsonov,et al.  Meglumine acridone acetate, the ionic salt of CMA and N-methylglucamine, induces apoptosis in human PBMCs via the mitochondrial pathway , 2019, Scientific Reports.

[5]  Ho Min Kim,et al.  Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency , 2019, Cytokine.

[6]  Mariana Marques,et al.  The Interplay between Human Cytomegalovirus and Pathogen Recognition Receptor Signaling , 2018, Viruses.

[7]  Yujun Liu,et al.  Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein , 2018, PLoS pathogens.

[8]  K. Hashimoto,et al.  Involvement of herpes simplex virus type 1 UL13 protein kinase in induction of SOCS genes, the negative regulators of cytokine signaling , 2017, Microbiology and immunology.

[9]  Haiyang Xie,et al.  Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF. , 2015, Biochemical and biophysical research communications.

[10]  T. Han,et al.  Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways. , 2015, Journal of hepatology.

[11]  Thao Nguyen,et al.  The interferons and their receptors—distribution and regulation , 2012, Immunology and cell biology.

[12]  P. Hainaut,et al.  Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells , 2011, PloS one.

[13]  S. Lemon,et al.  Hepatitis A and hepatitis C viruses: divergent infection outcomes marked by similarities in induction and evasion of interferon responses. , 2010, Seminars in liver disease.

[14]  H. Kirchner,et al.  Enhancement by carprofen or indomethacin of interferon induction by 10-carboxymethyl-9-acridanone in murine cell cultures. , 1986, The Journal of general virology.

[15]  F. Marcucci,et al.  Production of Interferon‐β by Murine T‐Cell Lines Induced by 10‐Carboxymethyl‐9‐Acridanone , 1986, Scandinavian journal of immunology.

[16]  S. Grossberg,et al.  Protection against Japanese encephalitis virus in mice and hamsters by treatment with carboxymethylacridanone, a potent interferon inducer. , 1980, The Journal of infectious diseases.

[17]  D. Baltimore.  Expression of animal virus genomes , 1971 .

[18]  D. Tyrrell,et al.  Virus Isolations from Common Colds Occurring in a Residential School , 1962, British medical journal.

[19]  J. Lindenmann,et al.  Virus interference. I. The interferon , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[20]  R. Valentine,et al.  Virus interference. II. Some properties of interferon , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[21]  P. Mazin,et al.  Meglumin acridonacetate to treat COVID-19: prospect of using , 2020 .

[22]  H. Kirchner,et al.  Induction of interferon in murine bone marrow‐derived macrophage cultures by 10‐carboxymethyl‐9‐acridanone , 1982, European journal of immunology.