Occurrence of antibody to salivary duct epithelium in Sjogren's disease, rheumatoid arthritis, and other arthritides. A clinical and laboratory study.

Sj0gren's disease, first described in 1933 (Sj0gren, 1933), consists of chronic inflammation of the lacrimal and salivary glands leading to dryness of the eyes (keratoconjunctivitis sicca) and dryness of the mouth (xerostomia); in a proportion of patients lacrimal and salivary gland enlargement may also be present (Bloch, Buchanan, Wohl, and Bunim, 1965; Talal, 1966). In 50 to 60 per cent. of patients the disease may be associated with a connective tissue disorder, usually rheumatoid arthritis, but occasionally also with polymyositis, polyarteritis nodosa, progressive systemic sclerosis (scleroderma), and systemic lupus erythematosus. The term "sicca syndrome" or "sicca complex" is applied to those cases of Sj0gren's disease not associated with rheumatoid arthritis or other connective tissue disorders.

[1]  J. Nerup,et al.  Organ antibodies in disseminated lupus erythematosus. , 2009, Acta medica Scandinavica.

[2]  J. N. Morris,et al.  Mortality and hardness of local water-supplies. , 1968, Lancet.

[3]  J. Williamson,et al.  Effect of temperature and humidity in the Schirmer tear test. , 1967, British Journal of Ophthalmology.

[4]  R. B. Goudie,et al.  Serological and histological diagnosis of primary biliary cirrhosis , 1966, Journal of clinical pathology.

[5]  W. W. Buchanan,et al.  Gastric studies in sjögren's syndrome. , 1966, Gut.

[6]  J. J. Bunim,et al.  SJÖGREN'S SYNDROME: A Clinical, Pathological, and Serological Study of Sixty-two Cases , 1965, Medicine.

[7]  J. G. Walker,et al.  SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS. , 1965, Lancet.

[8]  W. W. Buchanan,et al.  Antinuclear and Precipitating Auto-antibodies in Sjögren's Syndrome * , 1965, Annals of the rheumatic diseases.

[9]  P. Halberg,et al.  A SPECIFIC ANTIBODY AGAINST THE EPITHELIUM OF THE SALIVARY DUCTS IN SERA FROM PATIENTS WITH SJOGREN'S SYNDROME 1 , 1964, Acta allergologica.

[10]  J. S. Beck,et al.  CLINICAL, PATHOLOGIC, AND SEROLOGIC STUDIES IN SJOEGREN'S SYNDROME; COMBINED CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH. , 1964, Annals of internal medicine.

[11]  J. Anderson,et al.  THE HISTOLOGICAL AND SECRETORY CHANGES IN THE STOMACH IN PATIENTS WITH AUTOIMMUNITY TO GASTRIC PARIETAL CELLS. , 1964, Lancet.

[12]  W. W. Buchanan,et al.  Precipitating Auto-Antibodies in the Connective Tissue Diseases , 1962, Annals of the rheumatic diseases.

[13]  D. Doniach,et al.  A stable sheep cell preparation for detecting thyroglobulin auto-antibodies and its clinical applications , 1961, Journal of clinical pathology.

[14]  W. W. Buchanan,et al.  Antibody to Thyroglobulin in Patients with Collagen Diseases , 1961, Scottish medical journal.

[15]  J. W. Henderson,et al.  Keratoconjunctivitis Sicca and Sjögren's Syndrome: Systemic Manifestations and Hematologic and Protein Abnormalities , 1960 .

[16]  D. Doniach,et al.  Cytoplasmic localization of "complement-fixing" auto-antigen in human thyroid epithelium. , 1959, British journal of experimental pathology.

[17]  B. Jones,et al.  Lacrimal and salivary precipitating antibodies in Sjögren's syndrome. , 1958, Lancet.

[18]  O. Steinbrocker,et al.  Therapeutic criteria in rheumatoid arthritis. , 1949, Journal of the American Medical Association.

[19]  J. Waterhouse,et al.  Post-mortem prevalence of focal lymphocytic adenitis of the submandibular salivary gland. , 1966, The Journal of pathology and bacteriology.

[20]  W. M. Park,et al.  Hydrostatic sialography. , 1966, Radiology.

[21]  B. Hamilton.  A New Conception of Keratoconjunctivitis Sicca , 1946, The Indian Medical Gazette.