Color-matched esophagus phantom for fluorescent imaging

We developed a stable, reproducible three-dimensional optical phantom for the evaluation of a wide-field endoscopic molecular imaging system. This phantom mimicked a human esophagus structure with flexibility to demonstrate body movements. At the same time, realistic visual appearance and diffuse spectral reflectance properties of the tissue were simulated by a color matching methodology. A photostable dye-in-polymer technology was applied to represent biomarker probed “hot-spot” locations. Furthermore, fluorescent target quantification of the phantom was demonstrated using a 1.2mm ultrathin scanning fiber endoscope with concurrent fluorescence-reflectance imaging.

[1]  Chenying Yang,et al.  Color-matched and fluorescence-labeled esophagus phantom and its applications , 2013, Journal of biomedical optics.

[2]  A. Karim,et al.  Multimodal optical studies of single and clustered colloidal quantum dots for the long-term optical property evaluation of quantum dot-based molecular imaging phantoms , 2012, Biomedical optics express.

[3]  Jessica C. Ramella-Roman,et al.  Three-dimensional phantoms for curvature correction in spatial frequency domain imaging , 2012, Biomedical optics express.

[4]  R. Richards-Kortum,et al.  Advanced Endoscopic Imaging for Barrett’s Esophagus: Current Options and Future Directions , 2012, Current Gastroenterology Reports.

[5]  Eric J. Seibel,et al.  Surface Mosaics of the Bladder Reconstructed From Endoscopic Video for Automated Surveillance , 2012, IEEE Transactions on Biomedical Engineering.

[6]  Rebecca C Fitzgerald,et al.  Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus , 2012, Nature Medicine.

[7]  Eric J. Seibel,et al.  Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopy , 2012, Photonics West - Biomedical Optics.

[8]  Prateek Sharma,et al.  Barrett's esophagus and cancer risk: a more realistic estimate. , 2011, Seminars in thoracic and cardiovascular surgery.

[9]  Y. Hwangbo,et al.  Narrow-band imaging versus I-Scan for the real-time histological prediction of diminutive colonic polyps: a prospective comparative study by using the simple unified endoscopic classification. , 2011, Gastrointestinal endoscopy.

[10]  U. Netz,et al.  Calibration standards and phantoms for fluorescence optical measurements , 2011 .

[11]  Thomas D. Wang,et al.  Future and advances in endoscopy , 2011, Journal of biophotonics.

[12]  Leonard Y. Nelson,et al.  Red-shifted fluorescence of sound dental hard tissue. , 2011, Journal of biomedical optics.

[13]  K. Heia,et al.  Effects of storage atmosphere and heme state on the color and visible reflectance spectra of salmon ( Salmo salar ) fillets. , 2011, Journal of agricultural and food chemistry.

[14]  Thomas D. Wang,et al.  Molecular Imaging for Guiding Oncologic Prognosis and Therapy in Esophageal Adenocarcinoma , 2011, Hospital practice.

[15]  G. Jenkins,et al.  Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in High‐Grade Dysplasia and Adenocarcinoma of the Esophagus and May Represent a Biomarker of Histological Progression in Barrett's Esophagus (BE) , 2011 .

[16]  Brian C. Wilson,et al.  Homogenized tissue phantoms for quantitative evaluation of subsurface fluorescence contrast. , 2011, Journal of biomedical optics.

[17]  J. Bergman,et al.  Autofluorescence and narrow band imaging in Barrett's esophagus. , 2010, Gastroenterology clinics of North America.

[18]  Thomas D. Wang,et al.  Affinity peptide for targeted detection of dysplasia in Barrett's esophagus. , 2010, Gastroenterology.

[19]  Stavros G Demos,et al.  Characterizing the origin of autofluorescence in human esophageal epithelium under ultraviolet excitation. , 2010, Optics express.

[20]  Vadim Backman,et al.  Analysis of pressure, angle and temporal effects on tissue optical properties from 
polarization-gated spectroscopic probe measurements , 2010, Biomedical optics express.

[21]  Timothy D. Soper,et al.  Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging , 2010, Journal of biophotonics.

[22]  Thomas D. Wang,et al.  Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging , 2010, Cancers.

[23]  Mitsuhiro Fujishiro,et al.  Novel image-enhanced endoscopy with i-scan technology. , 2010, World journal of gastroenterology.

[24]  Thomas D. Wang,et al.  maging and Advanced Technology olecular Imaging in Gastrointestinal Endoscopy , 2022 .

[25]  D. D. de Bruin,et al.  Optical phantoms of varying geometry based on thin building blocks with controlled optical properties. , 2010, Journal of biomedical optics.

[26]  E. Seibel,et al.  New endoscopic and cytologic tools for cancer surveillance in the digestive tract. , 2009, Gastrointestinal endoscopy clinics of North America.

[27]  Thomas D. Wang,et al.  Targeted endoscopic imaging. , 2009, Gastrointestinal endoscopy clinics of North America.

[28]  Max Q.-H. Meng,et al.  Computer-based detection of bleeding and ulcer in wireless capsule endoscopy images by chromaticity moments , 2009, Comput. Biol. Medicine.

[29]  Eric Edell,et al.  Detection and Localization of Intraepithelial Neoplasia and Invasive Carcinoma Using Fluorescence-Reflectance Bronchoscopy: An International, Multicenter Clinical Trial , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[30]  Wei-Chiang Lin,et al.  Effects of probe contact pressure on in vivo optical spectroscopy. , 2008, Optics express.

[31]  Christopher H Contag,et al.  Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy. , 2008, Nature medicine.

[32]  Michael B. Kimmey,et al.  Tethered Capsule Endoscopy, A Low-Cost and High-Performance Alternative Technology for the Screening of Esophageal Cancer and Barrett's Esophagus , 2008, IEEE Transactions on Biomedical Engineering.

[33]  Katherine W. Calabro,et al.  Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures. , 2008, Journal of biomedical optics.

[34]  Ralph Weissleder,et al.  Quantitative real-time catheter-based fluorescence molecular imaging in mice. , 2007, Radiology.

[35]  P. Choyke.  Is it possible to quantify fluorescence during optical endoscopy? , 2007, Radiology.

[36]  Brian C Wilson,et al.  Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedside. , 2007, Journal of biomedical optics.

[37]  J. Ajani,et al.  Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas , 2007, Cancer.

[38]  Urs Utzinger,et al.  In vitro model for endogenous optical signatures of collagen. , 2006, Journal of biomedical optics.

[39]  I. Georgakoudi.  The color of cancer , 2006 .

[40]  B. Pogue,et al.  Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. , 2006, Journal of biomedical optics.

[41]  B. Wilson,et al.  Spectroscopy and fluorescence in esophageal diseases. , 2006, Best practice & research. Clinical gastroenterology.

[42]  J. Roodenburg,et al.  Autofluorescence and diffuse reflectance spectroscopy for oral oncology , 2005, Lasers in surgery and medicine.

[43]  Brian C. Wilson,et al.  Autofluorescence-Based Detection of Early Neoplasia in Patients with Barrett’s Esophagus , 2004, Digestive Diseases.

[44]  M. Solaymani-Dodaran,et al.  Risk of oesophageal cancer in Barrett’s oesophagus and gastro-oesophageal reflux , 2004, Gut.

[45]  Masahiro Yamaguchi,et al.  Appearance of enhanced tissue features in narrow-band endoscopic imaging. , 2004, Journal of biomedical optics.

[46]  Brian C Wilson,et al.  Molecular Fluorescence Excitation–Emission Matrices Relevant to Tissue Spectroscopy¶ , 2003, Photochemistry and photobiology.

[47]  Wei Zheng,et al.  Optimal excitation‐emission wavelengths for autofluorescence diagnosis of bladder tumors , 2003, International journal of cancer.

[48]  Rebecca Richards-Kortum,et al.  Realistic three-dimensional epithelial tissue phantoms for biomedical optics. , 2002, Journal of biomedical optics.

[49]  K. Badizadegan,et al.  Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus. , 2001, Gastroenterology.

[50]  R Marchesini,et al.  A phantom with tissue‐like optical properties in the visible and near infrared for use in photomedicine , 2001, Lasers in surgery and medicine.

[51]  R Richards-Kortum,et al.  Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: results from an animal model. , 2000, Optics express.

[52]  Gary Longton,et al.  Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets , 2000, American Journal of Gastroenterology.

[53]  P. Monnier,et al.  Three‐dimensional optical phantom and its application in photodynamic therapy , 1997, Lasers in surgery and medicine.

[54]  M L Lesiecki,et al.  Use of the thermal lens technique to measure the luminescent quantum yields of dyes in PMMA for luminescent solar concentrators. , 1982, Applied optics.

[55]  M. Lambropoulos,et al.  Fluorol 7GA: An efficient yellow-green dye for flashlamp-pumped lasers , 1975 .