Enhanced suicidal erythrocyte death in acute cardiac failure

A common complication of acute cardiac failure (AHF) is anaemia, which negatively influences the clinical outcome. Causes of anaemia include enhanced eryptosis, a suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation. Signalling triggering eryptosis include oxidative stress, increase of cytosolic Ca2+‐activity ([Ca2+]i) and ceramide. The present study explored whether AHF is associated with accelerated eryptosis.

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