Potent and biostable inhibitors of the main protease of SARS-CoV-2
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N. Kishimoto | K. Nakano | T. Okamura | Naoya Wada | H. Tamamura | J. Saruwatari | H. Bulut | S. Hattori | S. Misumi | N. Takamune | H. Hayashi | Takuya Kobayakawa | Kohei Tsuji | Miyuki Nakayama | D. Das | T. Kawada | H. Nakano | Nobuyo Higashi-Kuwata | N. Higashi-Kuwata | H. Mitsuya | M. Hori | T. Ishii | Chika Azuma | Takato Onishi | Kouki Shinohara | Yutaro Miura | K. Shinohara | Hiroki Nakano | Kenta Nakano
[1] Hao Tan,et al. Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir , 2022, bioRxiv.
[2] B. Sankaran,et al. A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals , 2022, European Journal of Medicinal Chemistry.
[3] Kai S Yang,et al. Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir , 2022, Journal of medicinal chemistry.
[4] Xinwen Chen,et al. The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate , 2022, European Journal of Medicinal Chemistry.
[5] Y. Orba,et al. Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19 , 2022, Journal of medicinal chemistry.
[6] Hao Tan,et al. Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity , 2021, Journal of the American Chemical Society.
[7] G. Otting,et al. Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir , 2021, bioRxiv.
[8] T. Itoh,et al. Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19 , 2021, ACS central science.
[9] K. Gajiwala,et al. An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19 , 2021, Science.
[10] C. Müller,et al. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. , 2021, Journal of medicinal chemistry.
[11] R. Myers,et al. Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant , 2021, The New England journal of medicine.
[12] Taylor M. Barrett,et al. Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L , 2021, Chemical science.
[13] J. Vederas,et al. Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability , 2021, Journal of medicinal chemistry.
[14] Chunlong Ma,et al. Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir , 2021, ACS pharmacology & translational science.
[15] Yuquan Wei,et al. SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model , 2021, Science.
[16] Arun K. Ghosh,et al. A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication , 2021, Nature Communications.
[17] D. Venzon,et al. Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV. , 2020, Journal of hepatology.
[18] R. Likić,et al. Will vaccination refusal prolong the war on SARS-CoV-2? , 2020, Postgraduate Medical Journal.
[19] K. Gajiwala,et al. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 , 2020, Journal of medicinal chemistry.
[20] Arun K. Ghosh,et al. Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity , 2020, Scientific Reports.
[21] Joe Pardo,et al. The journey of remdesivir: from Ebola to COVID-19 , 2020, Drugs in context.
[22] R. D’Aquila,et al. Broad-spectrum inhibition of coronavirus main and papain-like proteases by HCV drugs , 2020 .
[23] H. Mitsuya,et al. Sustaining containment of COVID-19: global sharing for pandemic response. , 2020, Global health & medicine.
[24] Edward Livingston,et al. Coronavirus Disease 2019 (COVID-19) in Italy. , 2020, JAMA.
[25] Fumihiro Kato,et al. Development of Genetic Diagnostic Methods for Novel Coronavirus 2019 (nCoV-2019) in Japan. , 2020, Japanese journal of infectious diseases.
[26] Jing Zhao,et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia , 2020, The New England journal of medicine.
[27] G. Gao,et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019 , 2020, The New England journal of medicine.
[28] Taylor M. Barrett,et al. Fluorescent Probes for Studying Thioamide Positional Effects on Proteolysis Reveal Insight into Resistance to Cysteine Proteases , 2019, Chembiochem : a European journal of chemical biology.
[29] Arun K. Ghosh,et al. Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants , 2019, Antimicrobial Agents and Chemotherapy.
[30] Kunio Hirata,et al. ZOO: an automatic data-collection system for high-throughput structure analysis in protein microcrystallography , 2019, Acta crystallographica. Section D, Structural biology.
[31] Arun K. Ghosh,et al. Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants , 2018, ChemMedChem.
[32] N. Meanwell. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. , 2018, Journal of medicinal chemistry.
[33] Gwyndaf Evans,et al. DIALS: implementation and evaluation of a new integration package , 2018, Acta crystallographica. Section D, Structural biology.
[34] Taylor M. Barrett,et al. Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones. , 2017, Journal of the American Chemical Society.
[35] F. Diederich,et al. Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the π‐Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds , 2016, ChemMedChem.
[36] M. D. Hill,et al. Applications of Fluorine in Medicinal Chemistry. , 2015, Journal of medicinal chemistry.
[37] R. Hilgenfeld. From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design , 2014, The FEBS journal.
[38] Noriyuki Furuichi,et al. Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties. , 2013, ACS medicinal chemistry letters.
[39] E. Freire,et al. Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies , 2013, European Journal of Medicinal Chemistry.
[40] S. Yokoyama,et al. Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C‐like protease (SARS‐CoV 3CL pro) from its polyproteins , 2013, The FEBS journal.
[41] E. Freire,et al. Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety , 2012, Bioorganic & Medicinal Chemistry.
[42] Thomas Jaki,et al. Estimation of pharmacokinetic parameters with the R package PK , 2011 .
[43] N. Pannu,et al. REFMAC5 for the refinement of macromolecular crystal structures , 2011, Acta crystallographica. Section D, Biological crystallography.
[44] Y. Liu,et al. Maturation Mechanism of Severe Acute Respiratory Syndrome (SARS) Coronavirus 3C-like Proteinase , 2010, The Journal of Biological Chemistry.
[45] Peng Zhou,et al. Fluorine Bonding - How Does It Work In Protein-Ligand Interactions? , 2009, J. Chem. Inf. Model..
[46] F. Diederich,et al. A fluorine scan of non-peptidic inhibitors of neprilysin: Fluorophobic and fluorophilic regions in an enzyme active site , 2008 .
[47] Arun K. Ghosh,et al. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors , 2007, Bioorganic & Medicinal Chemistry Letters.
[48] Andrew D Westwell,et al. The role of fluorine in medicinal chemistry , 2007, Journal of enzyme inhibition and medicinal chemistry.
[49] Manfred Kansy,et al. A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values , 2006, ChemMedChem.
[50] Zhongbin Chen,et al. The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity , 2005, Journal of Virology.
[51] R. Ménard,et al. The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating Enzyme , 2005, Journal of Virology.
[52] A. W. Schüttelkopf,et al. PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. , 2004, Acta crystallographica. Section D, Biological crystallography.
[53] B. Smart. Fluorine substituent effects (on bioactivity) , 2001 .
[54] D. Matthews,et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. , 1999, Journal of medicinal chemistry.
[55] H. Rapoport,et al. Thiopeptide Synthesis. α-Amino Thionoacid Derivatives of Nitrobenzotriazole as Thioacylating Agents. , 1997 .
[56] H. Rapoport,et al. Thiopeptide Synthesis. alpha-Amino Thionoacid Derivatives of Nitrobenzotriazole as Thioacylating Agents. , 1996, The Journal of organic chemistry.
[57] R. Allison,et al. THE USE OF ETHIONAMIDE IN COMBINED DRUG REGIMENS IN THE RE-TREATMENT OF ISONIAZID-RESISTANT PULMONARY TUBERCULOSIS. , 1965, The American review of respiratory disease.
[58] Yuquan Wei,et al. SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model , 2021 .
[59] Alexei Vagin,et al. Molecular replacement with MOLREP. , 2010, Acta crystallographica. Section D, Biological crystallography.