The Fate and Occurrence of Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes during Advanced Wastewater Treatment and Disinfection: A Review

Antimicrobial resistance (AMR) is a serious problem for modern society, not only associated with clinical environments, but also the natural environment. Conventional wastewater treatment plants (WWTPs) are important nodes for the dissemination of antibiotic resistance to the aquatic environment since they are reservoirs of antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs), and antibiotic residues. WWTPs are not designed to remove these antibiotic resistance determinants from wastewater, and as a result, they are present in treated effluent, leading to environmental and public health concerns regarding wastewater disposal and reuse. Additional treatments combined with conventional WWTPs can be barriers to the spread of AMR to the environment. In order to understand the effect of wastewater treatment methods on the removal of ARB and ARGs, an extensive bibliographic study was conducted. This review summarizes the efficiency of conventional disinfection methods, tertiary wastewater treatment, and advanced oxidation processes (AOPs) to remove ARB and ARGs from wastewater. In the context of the revised Urban Wastewater Treatment Directive 91/271/EEC, further studies are needed on the removal potential of AOPs on a full-scale, as they offer great potential for the removal of ARB and ARGs with a low formation of toxic by-products compared to conventional disinfection methods.

[1]  S. Hassan,et al.  Plant-Based Copper Oxide Nanoparticles; Biosynthesis, Characterization, Antibacterial Activity, Tanning Wastewater Treatment, and Heavy Metals Sorption , 2023, Catalysts.

[2]  S. Gummadi,et al.  Inactivation of antibiotic resistant bacteria and elimination of transforming ability of plasmid carrying single and dual drug resistance genes by electro-oxidation using Ti/Sb-SnO2/PbO2 anode , 2023, Chemical Engineering Journal.

[3]  Marwa El-Sesy,et al.  Adsorptive removal of levofloxacin and antibiotic resistance genes from hospital wastewater by nano-zero-valent iron and nano-copper using kinetic studies and response surface methodology , 2023, Bioresources and Bioprocessing.

[4]  L. Rizzo,et al.  Neutral (Fe3+-Nta) and Acidic (Fe2+) Ph Solar Photo-Fenton vs Chlorination: Effective Urban Wastewater Disinfection Does Not Mean Control of Antibiotic Resistance , 2022, SSRN Electronic Journal.

[5]  Georgios Bampos,et al.  Tertiary Wastewater Treatment Technologies: A Review of Technical, Economic, and Life Cycle Aspects , 2022, Processes.

[6]  T. Schwartz,et al.  Membrane bioreactor followed by solar photo-Fenton oxidation: Bacterial community structure changes and bacterial reduction. , 2022, Science of the Total Environment.

[7]  O. Okoh,et al.  The effectiveness of silver nanoparticles as a clean-up material for water polluted with bacteria DNA conveying antibiotics resistance genes: Effect of different molar concentrations and competing ions , 2022, OpenNano.

[8]  Zhiguo Yuan,et al.  Simultaneous Removal of Antibiotic Resistant Bacteria, Antibiotic Resistance Genes, and Micropollutants by FeS2@GO-Based Heterogeneous Photo-Fenton Process. , 2022, Environmental science & technology.

[9]  T. R. Sreekrishnan,et al.  Effects of heavy metals on the development and proliferation of antibiotic resistance in urban sewage treatment plants. , 2022, Environmental pollution.

[10]  N. Kreuzinger,et al.  Advanced wastewater treatment with ozonation and granular activated carbon filtration: Inactivation of antibiotic resistance targets in a long-term pilot study. , 2022, Journal of hazardous materials.

[11]  J. Drewes,et al.  Removal of antibiotic microbial resistance by micro- and ultrafiltration of secondary wastewater effluents at pilot scale. , 2022, Science of the Total Environment.

[12]  J. Crespo,et al.  Nanofiltration as an Efficient Tertiary Wastewater Treatment: Elimination of Total Bacteria and Antibiotic Resistance Genes from the Discharged Effluent of a Full-Scale Wastewater Treatment Plant , 2022, Antibiotics.

[13]  Barbara Drigo,et al.  The effect of ultrafiltration process on the fate of antibiotic-related microcontaminants, pathogenic microbes, and toxicity in urban wastewater. , 2022, Journal of hazardous materials.

[14]  M. Achary,et al.  Degradation and inactivation of chromosomal and plasmid encoded resistance genes/ARBs and the impact of different matrices on UV and UV/H2O2 based advanced oxidation process. , 2022, Science of the Total Environment.

[15]  J. Marugán,et al.  Microplastics in fresh- and wastewater are potential contributors to antibiotic resistance- A minireview , 2022, Journal of Hazardous Materials Advances.

[16]  J. P. van der Hoek,et al.  Removal of Antibiotic Resistance From Municipal Secondary Effluents by Ozone-Activated Carbon Filtration , 2022, Frontiers in Environmental Science.

[17]  J. Byrne,et al.  Biological Layer in Household Slow Sand Filters: Characterization and Evaluation of the Impact on Systems Efficiency , 2022, Water.

[18]  Q. Wen,et al.  Potassium ferrate combined with ultrafiltration for treating secondary effluent: Efficient removal of antibiotic resistance genes and membrane fouling alleviation. , 2022, Water research.

[19]  Zhongbing Chen,et al.  Removal of Escherichia coli from domestic sewage using biological sand filters: Reduction effect and microbial community analysis. , 2022, Environmental research.

[20]  Mingwei Lin,et al.  Wastewater treatment and emerging contaminants: Bibliometric analysis. , 2022, Chemosphere.

[21]  Diego F. Sánchez,et al.  Disinfection of hospital-derived antibiotic-resistant bacteria at source using peracetic acid , 2022, Journal of Water Process Engineering.

[22]  Yanan Zhang,et al.  Removal of antibiotics pollutants in wastewater by UV-based advanced oxidation processes: Influence of water matrix components, processes optimization and application: A review , 2022, Journal of Water Process Engineering.

[23]  K. Wan,et al.  Effect of the ultraviolet/chlorine process on microbial community structure, typical pathogens, and antibiotic resistance genes in reclaimed water , 2021, Frontiers of Environmental Science & Engineering.

[24]  Cuimin Feng,et al.  Removal of antibiotic resistance genes in secondary effluent by slow filtration-NF process , 2021, Water Science and Technology.

[25]  Yongmei Li,et al.  Insight into using a novel ultraviolet/peracetic acid combination disinfection process to simultaneously remove antibiotics and antibiotic resistance genes in wastewater: Mechanism and comparison with conventional processes. , 2021, Water research.

[26]  M. Govarthanan,et al.  Microplastic-associated pathogens and antimicrobial resistance in environment. , 2021, Chemosphere.

[27]  Qing-bin Yuan,et al.  Enhanced propagation of intracellular and extracellular antibiotic resistance genes in municipal wastewater by microplastics. , 2021, Environmental pollution.

[28]  Jinlong Zhang,et al.  Efficient removal of antibiotic-resistant bacteria and intracellular antibiotic resistance genes by heterogeneous activation of peroxymonosulfate on hierarchical macro-mesoporous Co3O4-SiO2 with enhanced photogenerated charges. , 2021, Journal of hazardous materials.

[29]  V. Vivekanand,et al.  Impact of combined chlorine and UV technology on the bacterial diversity, antibiotic resistance genes and disinfection by-products in treated sewage. , 2021, Bioresource technology.

[30]  D. Fatta-Kassinos,et al.  Simultaneous inactivation of multidrug-resistant Escherichia coli and enterococci by peracetic acid in urban wastewater: Exposure-based kinetics and comparison with chlorine. , 2021, Water research.

[31]  C. Manaia,et al.  Reduction of antibiotic resistance determinants in urban wastewater by ozone: Emphasis on the impact of wastewater matrix towards the inactivation kinetics, toxicity and bacterial regrowth. , 2021, Journal of hazardous materials.

[32]  Liping Wang,et al.  Assessment of the UV/Chlorine Process in the Disinfection of Pseudomonas aeruginosa: Efficiency and Mechanism. , 2021, Environmental science & technology.

[33]  Xiaomei Yang,et al.  Microplastics are a hotspot for antibiotic resistance genes: Progress and perspective. , 2021, The Science of the total environment.

[34]  Guiying Li,et al.  Formation mechanisms of viable but nonculturable bacteria through induction by light-based disinfection and their antibiotic resistance gene transfer risk: A review , 2021, Critical Reviews in Environmental Science and Technology.

[35]  J. Turnidge,et al.  Inactivation, removal, and regrowth potential of opportunistic pathogens and antimicrobial resistance genes in recycled water systems. , 2021, Water research.

[36]  A. Pruden,et al.  Quantitative analysis of horizontal gene transfer in complex systems. , 2021, Current opinion in microbiology.

[37]  O. Okoh,et al.  Potentials of metallic nanoparticles for the removal of antibiotic resistant bacteria and antibiotic resistance genes from wastewater: A critical review , 2021 .

[38]  L. Rizzo,et al.  Review of aminopolycarboxylic acids–based metal complexes application to water and wastewater treatment by (photo-)Fenton process at neutral pH , 2021 .

[39]  Shaobin Wang,et al.  Advanced oxidation processes for water disinfection: Features, mechanisms and prospects , 2021 .

[40]  A. P. Aguilar,et al.  Solar photon-Fenton process eliminates free plasmid DNA harboring antimicrobial resistance genes from wastewater , 2021, Journal of environmental management.

[41]  M. I. Polo-López,et al.  Perspectives of the solar photo-Fenton process against the spreading of pathogens, antibiotic-resistant bacteria and genes in the environment , 2021 .

[42]  I. Arslan-Alaton,et al.  Effect of UV-A-assisted iron-based and UV-C-driven oxidation processes on organic matter and antibiotic resistance removal in tertiary treated urban wastewater , 2021 .

[43]  Ioannis D. Kampouris,et al.  Antibiotic resistance gene load and irrigation intensity determine the impact of wastewater irrigation on antimicrobial resistance in the soil microbiome. , 2021, Water research.

[44]  T. Schwartz,et al.  Determination of antibiotic resistance genes in a WWTP-impacted river in surface water, sediment, and biofilm: Influence of seasonality and water quality. , 2021, The Science of the total environment.

[45]  T. Naseem,et al.  The role of some important metal oxide nanoparticles for wastewater and antibacterial applications: A review , 2021 .

[46]  M. Bronze,et al.  Occurrence of Antibiotics, Antibiotic Resistance Genes and Viral Genomes in Wastewater Effluents and Their Treatment by a Pilot Scale Nanofiltration Unit , 2020, Membranes.

[47]  C. Polprasert,et al.  Comparative removal of two antibiotic resistant bacteria and genes by the simultaneous use of chlorine and UV irradiation (UV/chlorine): Influence of free radicals on gene degradation. , 2020, The Science of the total environment.

[48]  Taotao Zhuang,et al.  Synergistic effect of UV/chlorine in bacterial inactivation, resistance gene removal, and gene conjugative transfer blocking. , 2020, Water research.

[49]  T. Schwartz,et al.  A chemical, microbiological and (eco)toxicological scheme to understand the efficiency of UV-C/H2O2 oxidation on antibiotic-related microcontaminants in treated urban wastewater. , 2020, The Science of the total environment.

[50]  S. Sherchan,et al.  Removal of Antibiotic Resistance Genes at Two Conventional Wastewater Treatment Plants of Louisiana, USA , 2020, Water.

[51]  H. Rijnaarts,et al.  Fate of antibiotics and antibiotic resistance genes during conventional and additional treatment technologies in wastewater treatment plants. , 2020, The Science of the total environment.

[52]  V. Wu,et al.  Integrity of the Escherichia coli O157:H7 Cell Wall and Membranes After Chlorine Dioxide Treatment , 2020, Frontiers in Microbiology.

[53]  C. Manaia,et al.  Investigating the impact of UV-C/H2O2 and sunlight/H2O2 on the removal of antibiotics, antibiotic resistance determinants and toxicity present in urban wastewater , 2020, Chemical Engineering Journal.

[54]  Zhiqiang Shen,et al.  Chlorine disinfection promotes the exchange of antibiotic resistance genes across bacterial genera by natural transformation , 2020, The ISME Journal.

[55]  Christa S. McArdell,et al.  Best available technologies and treatment trains to address current challenges in urban wastewater reuse for irrigation of crops in EU countries. , 2020, The Science of the total environment.

[56]  W. Uhl,et al.  Combined membrane filtration and 265 nm UV irradiation for effective removal of cell free antibiotic resistance genes from feed water and concentrate , 2020 .

[57]  D. Dionysiou,et al.  Elucidating sulfate radical-mediated disinfection profiles and mechanisms of Escherichia coli and Enterococcus faecalis in municipal wastewater. , 2020, Water research.

[58]  Guang-li Cao,et al.  Removal of antibiotic resistant bacteria and antibiotic resistance genes in wastewater effluent by UV-activated persulfate. , 2020, Journal of hazardous materials.

[59]  Lauren M. Sassoubre,et al.  Inactivation ofE. coli,Enterococcusspp., somatic coliphage, andCryptosporidium parvumin wastewater by peracetic acid (PAA), sodium hypochlorite, and combined PAA-ultraviolet disinfection , 2020 .

[60]  Chris F. McConville,et al.  Antibacterial Properties of Graphene Oxide-Copper Oxide Nanoparticle Nanocomposites. , 2019, ACS applied bio materials.

[61]  D. Santoro,et al.  Inactivation kinetics of antibiotic resistant Escherichia coli in secondary wastewater effluents by peracetic and performic acids. , 2019, Water research.

[62]  R. Jamieson,et al.  Lateral flow sand filters are effective for removal of antibiotic resistance genes from domestic wastewater. , 2019, Water research.

[63]  T. Schwartz,et al.  Dissemination prevention of antibiotic resistant and facultative pathogenic bacteria by ultrafiltration and ozone treatment at an urban wastewater treatment plant , 2019, Scientific Reports.

[64]  W. Jin,et al.  Ozone disinfection of chlorine-resistant bacteria in drinking water. , 2019, Water research.

[65]  D. Dionysiou,et al.  Inactivation of pathogenic microorganisms by sulfate radical: Present and future , 2019, Chemical Engineering Journal.

[66]  F. Baquero,et al.  Defining and combating antibiotic resistance from One Health and Global Health perspectives , 2019, Nature Microbiology.

[67]  T. Fernandes,et al.  Continuous ozonation of urban wastewater: Removal of antibiotics, antibiotic-resistant Escherichia coli and antibiotic resistance genes and phytotoxicity. , 2019, Water research.

[68]  P. Hufnagl,et al.  Removal of extracellular free DNA and antibiotic resistance genes from water and wastewater by membranes ranging from microfiltration to reverse osmosis. , 2019, Water research.

[69]  Sheetal Sharma,et al.  Review on advances in photocatalytic water disinfection utilizing graphene and graphene derivatives-based nanocomposites , 2019, Journal of Environmental Chemical Engineering.

[70]  Dong Yang,et al.  Chlorine injury enhances antibiotic resistance in Pseudomonas aeruginosa through over expression of drug efflux pumps. , 2019, Water research.

[71]  Pamela J. B. Brown,et al.  Higher functionality of bacterial plasmid DNA in water after peracetic acid disinfection compared with chlorination. , 2019, The Science of the total environment.

[72]  Q. Wen,et al.  Impacts of advanced treatment processes on elimination of antibiotic resistance genes in a municipal wastewater treatment plant , 2019, Frontiers of Environmental Science & Engineering.

[73]  T. Schwartz,et al.  Solar photo-Fenton oxidation followed by adsorption on activated carbon for the minimisation of antibiotic resistance determinants and toxicity present in urban wastewater , 2019, Applied Catalysis B: Environmental.

[74]  L. Fan,et al.  Moving from the traditional paradigm of pathogen inactivation to controlling antibiotic resistance in water - Role of ultraviolet irradiation. , 2019, The Science of the total environment.

[75]  J. Sidhu,et al.  Comparative removal of antibiotic resistance genes during chlorination, ozonation, and UV treatment. , 2019, International journal of hygiene and environmental health.

[76]  Mei-ting Guo,et al.  Antibiotic resistant bacteria survived from UV disinfection: Safety concerns on genes dissemination. , 2019, Chemosphere.

[77]  H. Ren,et al.  Kinetics and modeling of artificial sweeteners degradation in wastewater by the UV/persulfate process. , 2019, Water research.

[78]  P. Liang,et al.  Removal of antibiotic resistance genes in four full-scale membrane bioreactors. , 2019, The Science of the total environment.

[79]  D. Barceló,et al.  Assessment of full-scale tertiary wastewater treatment by UV-C based-AOPs: Removal or persistence of antibiotics and antibiotic resistance genes? , 2019, The Science of the total environment.

[80]  Yanbo Zhou,et al.  Removal of antibiotic resistance genes and control of horizontal transfer risk by UV, chlorination and UV/chlorination treatments of drinking water , 2019, Chemical Engineering Journal.

[81]  A. Gu,et al.  Antimicrobial resistance: A new threat from disinfection byproducts and disinfection of drinking water? , 2019, Current opinion in environmental science & health.

[82]  S. Barışçı,et al.  Mechanisms of the Escherichia coli and Enterococcus faecalis inactivation by ozone , 2019, LWT.

[83]  D. Fatta-Kassinos,et al.  Solar photo-Fenton oxidation for the removal of ampicillin, total cultivable and resistant E. coli and ecotoxicity from secondary-treated wastewater effluents , 2019, Chemical Engineering Journal.

[84]  A. Turolla,et al.  Disinfection by-products formation and ecotoxicological effects of effluents treated with peracetic acid: A review. , 2018, Chemosphere.

[85]  L. Truelstrup Hansen,et al.  Removal of antibiotic resistance genes in two tertiary level municipal wastewater treatment plants. , 2018, The Science of the total environment.

[86]  Charmaine Ng,et al.  Removal of antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in municipal wastewater by membrane bioreactor systems. , 2018, Water research.

[87]  Stefanos Giannakis,et al.  Solar photo-Fenton disinfection of 11 antibiotic-resistant bacteria (ARB) and elimination of representative AR genes. Evidence that antibiotic resistance does not imply resistance to oxidative treatment. , 2018, Water research.

[88]  Shenghua Zhang,et al.  Induction of Escherichia coli into a VBNC state through chlorination/chloramination and differences in characteristics of the bacterium between states. , 2018, Water research.

[89]  A. R. Fernandes,et al.  Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans” , 2018, Front. Microbiol..

[90]  Dong Yang,et al.  Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant. , 2018, Water research.

[91]  Proia Lorenzo,et al.  Antibiotic resistance in urban and hospital wastewaters and their impact on a receiving freshwater ecosystem. , 2018, Chemosphere.

[92]  J. C. Prata.  Microplastics in wastewater: State of the knowledge on sources, fate and solutions. , 2018, Marine pollution bulletin.

[93]  W. Uhl,et al.  Removal of antibiotic resistant E. coli in two Norwegian wastewater treatment plants and by nano- and ultra-filtration processes. , 2018, Water science and technology : a journal of the International Association on Water Pollution Research.

[94]  R. Torres-Palma,et al.  Elimination of carbapenem resistant Klebsiella pneumoniae in water by UV-C, UV-C/persulfate and UV-C/H2O2. Evaluation of response to antibiotic, residual effect of the processes and removal of resistance gene , 2018 .

[95]  D. Fatta-Kassinos,et al.  The role of operating parameters and oxidative damage mechanisms of advanced chemical oxidation processes in the combat against antibiotic-resistant bacteria and resistance genes present in urban wastewater. , 2018, Water research.

[96]  Spyros Foteinis,et al.  Environmental sustainability of the solar photo-Fenton process for wastewater treatment and pharmaceuticals mineralization at semi-industrial scale. , 2018, The Science of the total environment.

[97]  A. Karkman,et al.  Antibiotic-Resistance Genes in Waste Water. , 2017, Trends in microbiology.

[98]  Xiaochang C. Wang,et al.  Mechanisms of ultraviolet disinfection and chlorination of Escherichia coli: Culturability, membrane permeability, metabolism, and genetic damage. , 2017, Journal of environmental sciences.

[99]  M. Bali,et al.  Removal of heavy metals from wastewater using infiltration-percolation process and adsorption on activated carbon , 2018, International Journal of Environmental Science and Technology.

[100]  R. Nerenberg,et al.  Comparing peracetic acid and hypochlorite for disinfection of combined sewer overflows: Effects of suspended-solids and pH. , 2017, The Science of the total environment.

[101]  N. Fahrenfeld,et al.  Peracetic acid disinfection kinetics for combined sewer overflows: indicator organisms, antibiotic resistance genes, and microbial community. , 2017, Environmental science : water research & technology.

[102]  Vasileios Fotopoulos,et al.  The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes - A review. , 2017, Water research.

[103]  Limei Xu,et al.  Effects of ultraviolet disinfection on antibiotic‐resistant Escherichia coli from wastewater: inactivation, antibiotic resistance profiles and antibiotic resistance genes , 2017, Journal of applied microbiology.

[104]  Hong Chen,et al.  Effects and mechanisms of ultraviolet, chlorination, and ozone disinfection on antibiotic resistance genes in secondary effluents of municipal wastewater treatment plants , 2017 .

[105]  B. Björlenius,et al.  Pilot-scale removal of pharmaceuticals in municipal wastewater: Comparison of granular and powdered activated carbon treatment at three wastewater treatment plants. , 2017, Journal of environmental management.

[106]  Qixing Zhou,et al.  Efficient removal mechanism for antibiotic resistance genes from aquatic environments by graphene oxide nanosheet , 2017 .

[107]  Jian Wang,et al.  Distribution of antibiotic resistance in the effluents of ten municipal wastewater treatment plants in China and the effect of treatment processes. , 2017, Chemosphere.

[108]  C. Manaia,et al.  Ozonation and UV254nm radiation for the removal of microorganisms and antibiotic resistance genes from urban wastewater. , 2017, Journal of hazardous materials.

[109]  D. Fatta-Kassinos,et al.  On the capacity of ozonation to remove antimicrobial compounds, resistant bacteria and toxicity from urban wastewater effluents. , 2017, Journal of hazardous materials.

[110]  M. Gamal El-Din,et al.  Impact of environmental conditions on bacterial photoreactivation in wastewater effluents. , 2017, Environmental science. Processes & impacts.

[111]  J. Balcázar,et al.  Abundance of antibiotic resistance genes in five municipal wastewater treatment plants in the Monastir Governorate, Tunisia. , 2016, Environmental pollution.

[112]  C. Levantesi,et al.  Antibiotic resistance genes fate and removal by a technological treatment solution for water reuse in agriculture. , 2016, The Science of the total environment.

[113]  Frederik Hammes,et al.  Inactivation of Antibiotic Resistant Bacteria and Resistance Genes by Ozone: From Laboratory Experiments to Full-Scale Wastewater Treatment. , 2016, Environmental science & technology.

[114]  Gianluca Corno,et al.  Fitness and Recovery of Bacterial Communities and Antibiotic Resistance Genes in Urban Wastewaters Exposed to Classical Disinfection Treatments. , 2016, Environmental science & technology.

[115]  J. Kweon,et al.  Comparison of formation of disinfection by-products by chlorination and ozonation of wastewater effluents and their toxicity to Daphnia magna. , 2016, Environmental pollution.

[116]  F. Guarino,et al.  Antibiotic resistance spread potential in urban wastewater effluents disinfected by UV/H2O2 process. , 2016, The Science of the total environment.

[117]  Gregor Knopp,et al.  Ozone treatment of conditioned wastewater selects antibiotic resistance genes, opportunistic bacteria, and induce strong population shifts. , 2016, The Science of the total environment.

[118]  T. Kohn,et al.  Ammonia as an In Situ Sanitizer: Influence of Virus Genome Type on Inactivation , 2016, Applied and Environmental Microbiology.

[119]  H. Ren,et al.  Reduction of antibiotic resistance genes in municipal wastewater effluent by advanced oxidation processes. , 2016, The Science of the total environment.

[120]  Hong-Ying Hu,et al.  UV light tolerance and reactivation potential of tetracycline-resistant bacteria from secondary effluents of a wastewater treatment plant. , 2016, Journal of environmental sciences.

[121]  U. Alkan,et al.  Comparison of solar/H2O2 and solar photo-fenton processes for the disinfection of domestic wastewaters , 2016 .

[122]  S. Liss,et al.  Antibiotic resistance genes as an emerging environmental contaminant , 2016 .

[123]  G. Esposito,et al.  Coupling of membrane filtration and advanced oxidation processes for removal of pharmaceutical residues: A critical review , 2015 .

[124]  D. Fatta-Kassinos,et al.  Erythromycin oxidation and ERY-resistant Escherichia coli inactivation in urban wastewater by sulfate radical-based oxidation process under UV-C irradiation. , 2015, Water research.

[125]  Yi Luo,et al.  Prevalence and proliferation of antibiotic resistance genes in two municipal wastewater treatment plants. , 2015, Water research.

[126]  Peifang Wang,et al.  Fate of antibiotic resistant cultivable heterotrophic bacteria and antibiotic resistance genes in wastewater treatment processes. , 2015, Chemosphere.

[127]  L. Rizzo,et al.  Inactivation and regrowth of multidrug resistant bacteria in urban wastewater after disinfection by solar-driven and chlorination processes. , 2015, Journal of photochemistry and photobiology. B, Biology.

[128]  Jian Yang,et al.  Distinguishing effects of ultraviolet exposure and chlorination on the horizontal transfer of antibiotic resistance genes in municipal wastewater. , 2015, Environmental science & technology.

[129]  Y. Zhang,et al.  Inactivation of antibiotic resistance genes in municipal wastewater effluent by chlorination and sequential UV/chlorination disinfection. , 2015, The Science of the total environment.

[130]  Pei-Ying Hong,et al.  Removal of bacterial contaminants and antibiotic resistance genes by conventional wastewater treatment processes in Saudi Arabia: Is the treated wastewater safe to reuse for agricultural irrigation? , 2015, Water research.

[131]  Andreas N. Angelakis,et al.  Water Reuse in EU States: Necessity for Uniform Criteria to Mitigate Human and Environmental Risks , 2015 .

[132]  Jian Yang,et al.  Fate of Antibiotic Resistant Bacteria and Genes during Wastewater Chlorination: Implication for Antibiotic Resistance Control , 2015, PloS one.

[133]  C. Gallert,et al.  Removal of total and antibiotic resistant bacteria in advanced wastewater treatment by ozonation in combination with different filtering techniques. , 2015, Water research.

[134]  Pin Gao,et al.  Impacts of coexisting antibiotics, antibacterial residues, and heavy metals on the occurrence of erythromycin resistance genes in urban wastewater , 2015, Applied Microbiology and Biotechnology.

[135]  Q. Zhang,et al.  Degradation of carbamazepine and toxicity evaluation using the UV/persulfate process in aqueous solution , 2015 .

[136]  H. Ren,et al.  Variation of antibiotic resistance genes in municipal wastewater treatment plant with A2O-MBR system , 2015, Environmental Science and Pollution Research.

[137]  R. Karthikeyan,et al.  Effects of ultraviolet light disinfection on tetracycline-resistant bacteria in wastewater effluents. , 2014, Journal of water and health.

[138]  C. Manaia,et al.  Bacterial diversity and antibiotic resistance in water habitats: searching the links with the human microbiome. , 2014, FEMS microbiology reviews.

[139]  D. Fatta-Kassinos,et al.  Reduction of clarithromycin and sulfamethoxazole-resistant Enterococcus by pilot-scale solar-driven Fenton oxidation. , 2014, The Science of the total environment.

[140]  J. Rämö,et al.  Chemical aspects of peracetic acid based wastewater disinfection , 2014 .

[141]  Jian Yang,et al.  Ultraviolet reduction of erythromycin and tetracycline resistant heterotrophic bacteria and their resistance genes in municipal wastewater. , 2013, Chemosphere.

[142]  Hong-Ying Hu,et al.  Inactivation and regrowth of antibiotic-resistant bacteria by PAA disinfection in the secondary effluent of a municipal wastewater treatment plant. , 2013, Biomedical and environmental sciences : BES.

[143]  Yu Miao,et al.  Metagenomic Profiling of Antibiotic Resistance Genes and Mobile Genetic Elements in a Tannery Wastewater Treatment Plant , 2013, PloS one.

[144]  K. Oguma,et al.  Effects of salinity on photoreactivation of Escherichia coli after UV disinfection. , 2013, Journal of water and health.

[145]  Daqiang Yin,et al.  Prevalence of antibiotic resistance genes and their relationship with antibiotics in the Huangpu River and the drinking water sources, Shanghai, China. , 2013, The Science of the total environment.

[146]  T. Olmez-Hanci,et al.  Comparison of sulfate and hydroxyl radical based advanced oxidation of phenol , 2013 .

[147]  G. Ying,et al.  Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China. , 2013, The Science of the total environment.

[148]  C. Manaia,et al.  Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. , 2013, The Science of the total environment.

[149]  Y. Hung,et al.  A review on wastewater disinfection , 2013 .

[150]  M. Abid,et al.  Experimental study of dye removal from industrial wastewater by membrane technologies of reverse osmosis and nanofiltration , 2012, Iranian Journal of Environmental Health Science & Engineering.

[151]  U. Gunten,et al.  Chemistry of Ozone in Water and Wastewater Treatment , 2012 .

[152]  Amy Pruden,et al.  Ultraviolet disinfection of antibiotic resistant bacteria and their antibiotic resistance genes in water and wastewater. , 2012, Environmental science & technology.

[153]  R. Koczura,et al.  Multiresistant Enterobacteriaceae with class 1 and class 2 integrons in a municipal wastewater treatment plant. , 2012, Water research.

[154]  R. Moreira,et al.  Removal of pharmaceutical compounds in membrane bioreactors (MBR) applying submerged membranes , 2010 .

[155]  P. Bourke,et al.  Ozone Processing for Food Preservation: An Overview on Fruit Juice Treatments , 2010 .

[156]  J. L. Acero,et al.  Membrane filtration technologies applied to municipal secondary effluents for potential reuse. , 2010, Journal of hazardous materials.

[157]  H. Horn,et al.  Modeling of slow sand filtration for disinfection of secondary clarifier effluent. , 2010, Water research.

[158]  K. Nelson,et al.  Covariation and photoinactivation of traditional and novel indicator organisms and human viruses at a sewage-impacted marine beach. , 2009, Environmental science & technology.

[159]  G. Lowry,et al.  Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. , 2009, Nature nanotechnology.

[160]  M. Antonelli,et al.  Assessment of peracetic acid disinfected effluents by microbiotests. , 2009, Environmental science & technology.

[161]  P Kuschk,et al.  Slow sand filtration of secondary clarifier effluent for wastewater reuse. , 2009, Environmental science & technology.

[162]  M. I. Maldonado,et al.  Solar photo-Fenton treatment of pesticides in water: Effect of iron concentration on degradation and assessment of ecotoxicity and biodegradability , 2009 .

[163]  Damià Barceló,et al.  Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. , 2009, Water research.

[164]  Tong Zhang,et al.  Antibiotic resistance genes in water environment , 2009, Applied Microbiology and Biotechnology.

[165]  M. Boyle,et al.  Bactericidal Effect of Solar Water Disinfection under Real Sunlight Conditions , 2008, Applied and Environmental Microbiology.

[166]  J. Blanco,et al.  Solar photocatalytic disinfection of agricultural pathogenic fungi: Fusarium species , 2007 .

[167]  K. McMahon,et al.  Tetracycline resistance genes in activated sludge wastewater treatment plants. , 2007, Water research.

[168]  M. Gómez,et al.  Urban wastewater disinfection by filtration technologies , 2006 .

[169]  Mehmet Kitis,et al.  Disinfection of wastewater with peracetic acid: a review. , 2004, Environment international.

[170]  Christa S. McArdell,et al.  Occurrence and fate of macrolide antibiotics in wastewater treatment plants and in the Glatt Valley watershed, Switzerland. , 2003, Environmental science & technology.

[171]  Benito Jose Marinas,et al.  Kinetics of Escherichia coli inactivation with ozone , 1997 .

[172]  M. Meckes,et al.  Effect of UV light disinfection on antibiotic-resistant coliforms in wastewater effluents , 1982, Applied and environmental microbiology.