Computational analysis of image‐based drug profiling predicts synergistic drug combinations: Applications in triple‐negative breast cancer
暂无分享,去创建一个
Stephen T. C. Wong | Stephen T C Wong | E. Pasquier | Hong Zhao | Fuhai Li | D. Beck | M. Kavallaris | Sufang Zhang | Miriam Brandl
[1] R. M. Simpson,et al. TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms , 2014, Molecular oncology.
[2] Dan L. Longo Bruce A. Chabner. Cancer chemotherapy and biotherapy , 2013 .
[3] Luke A. Gilbert,et al. Defining principles of combination drug mechanisms of action , 2012, Proceedings of the National Academy of Sciences.
[4] Oliver Rath,et al. Kinesins and cancer , 2012, Nature Reviews Cancer.
[5] I. Burney. Cancer Chemotherapy and Biotherapy : Principles and Practice , 2011 .
[6] Chih-Jen Lin,et al. LIBSVM: A library for support vector machines , 2011, TIST.
[7] E. Pasquier,et al. ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties , 2010, Molecular Cancer Therapeutics.
[8] W. Kuo,et al. Activity of the Kinesin Spindle Protein Inhibitor Ispinesib (SB-715992) in Models of Breast Cancer , 2010, Clinical Cancer Research.
[9] T. Peretz,et al. Mitomycin C and Vinblastine: An Active Regimen in Previously Treated Breast Cancer Patients , 2009, Tumori.
[10] J. Lehár,et al. Synergistic drug combinations improve therapeutic selectivity , 2009, Nature Biotechnology.
[11] Xiaohua Ma,et al. Mechanisms of drug combinations: interaction and network perspectives , 2009, Nature Reviews Drug Discovery.
[12] Li Mao,et al. Algorithmic Guided Screening of Drug Combinations of Arbitrary Size for Activity against Cancer Cells , 2022 .
[13] Xiaobo Zhou,et al. An image score inference system for RNAi genome-wide screening based on fuzzy mixture regression modeling , 2009, J. Biomed. Informatics.
[14] Susan E. Abbatiello,et al. Erratum: Synergistic drug combinations tend to improve therapeutically relevant selectivity , 2009, Nature Biotechnology.
[15] C. Sander,et al. Models from experiments: combinatorial drug perturbations of cancer cells , 2008, Molecular systems biology.
[16] R. Sun,et al. Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm , 2008, Proceedings of the National Academy of Sciences.
[17] Jacob D. Feala,et al. Search Algorithms as a Framework for the Optimization of Drug Combinations , 2008, PLoS Comput. Biol..
[18] K. Hess,et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[19] E. Pasquier,et al. Microtubules: A dynamic target in cancer therapy , 2008, IUBMB life.
[20] A. Tutt,et al. Triple negative tumours: a critical review , 2007, Histopathology.
[21] Makoto Kinoshita,et al. [Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[22] Scott E. Fraser,et al. Imaging in Systems Biology , 2007, Cell.
[23] L. Mayer,et al. Optimizing combination chemotherapy by controlling drug ratios. , 2007, Molecular interventions.
[24] Sridhar Ramaswamy,et al. Rational design of cancer-drug combinations. , 2007, The New England journal of medicine.
[25] Stephen T. C. Wong,et al. An automated feedback system with the hybrid model of scoring and classification for solving over‐segmentation problems in RNAi high content screening , 2007, Journal of microscopy.
[26] C. Perou,et al. The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes , 2007, Clinical Cancer Research.
[27] Lani F. Wu,et al. Image-based multivariate profiling of drug responses from single cells , 2007, Nature Methods.
[28] I. Ohishi,et al. Disassembly of actin filaments by botulinum C2 toxin and actin‐filament‐disrupting agents induces assembly of microtubules in human leukaemia cell lines , 2007, Biology of the cell.
[29] H. Kitano. A robustness-based approach to systems-oriented drug design , 2007, Nature Reviews Drug Discovery.
[30] Jeffrey R. Jackson,et al. Targeted anti-mitotic therapies: can we improve on tubulin agents? , 2007, Nature Reviews Cancer.
[31] J. Lehár,et al. Multi-target therapeutics: when the whole is greater than the sum of the parts. , 2007, Drug discovery today.
[32] J. Weidhaas,et al. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] J. Dancey,et al. Strategies for optimizing combinations of molecularly targeted anticancer agents , 2006, Nature Reviews Drug Discovery.
[34] Lit-Hsin Loo,et al. Automated multivariate profiling of drug effects from fluorescence microscopy images , 2006, 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 2006..
[35] T. Mayer,et al. Synthesis and Biological Evaluation of Novel Eg5 Inhibitors , 2005, Chembiochem : a European journal of chemical biology.
[36] I. Vernos,et al. Development and Biological Evaluation of Potent and Specific Inhibitors of Mitotic Kinesin Eg5 , 2005, Chembiochem : a European journal of chemical biology.
[37] M. Piccart,et al. Phase II, open label study of SB-715992 (Ispinesib) in subjects with advanced or metastatic breast cancer , 2005 .
[38] Hiroaki Kitano,et al. Biological robustness , 2008, Nature Reviews Genetics.
[39] M. Elkabets,et al. Differential effects of monastrol in two human cell lines , 2004, Cellular and Molecular Life Sciences CMLS.
[40] M. Jordan,et al. Microtubules as a target for anticancer drugs , 2004, Nature Reviews Cancer.
[41] J. Lehár,et al. Systematic discovery of multicomponent therapeutics , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[42] D. Kerr,et al. Anticancer drug development , 2002 .
[43] B. Hill,et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. , 2001, Molecular pharmacology.
[44] B. Garvik,et al. Principles for the Buffering of Genetic Variation , 2001, Science.
[45] T. Enomoto,et al. Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade. , 1996, Cell structure and function.
[46] T. Chou,et al. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. , 1984, Advances in enzyme regulation.
[47] G. Bonadonna,et al. Combination chemotherapy of Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP , 1975, Cancer.
[48] S. Mathoulin-Pélissier,et al. How valid are claims for synergy in published clinical studies ? , 2022 .