Compartmentalized Synthesis and Degradation of Proteins in Neurons

[1]  J. Špaček,et al.  Three-Dimensional analysis of dendritic spines , 1983, Anatomy and Embryology.

[2]  Aaron Ciechanover,et al.  The Ubiquitin Proteasome System in Neurodegenerative Diseases Sometimes the Chicken, Sometimes the Egg , 2003, Neuron.

[3]  M. Ehlers,et al.  Dual Modes of Endoplasmic Reticulum-to-Golgi Transport in Dendrites Revealed by Live-Cell Imaging , 2003, The Journal of Neuroscience.

[4]  C. Bramham,et al.  Bursts of high‐frequency stimulation trigger rapid delivery of pre‐existing α‐CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long‐term potentiation in adult awake rats , 2003, The European journal of neuroscience.

[5]  Liqun Luo,et al.  Axon Pruning during Drosophila Metamorphosis Evidence for Local Degeneration and Requirement of the Ubiquitin-Proteasome System , 2003, Neuron.

[6]  K. Martin,et al.  The Ubiquitin Proteasome System Functions as an Inhibitory Constraint on Synaptic Strengthening , 2003, Current Biology.

[7]  K. Broadie,et al.  The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy , 2003, Current Biology.

[8]  Tatsuo Suzuki,et al.  Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain , 2003, Brain Research.

[9]  A. Guidotti,et al.  A reelin–integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[10]  P. Stanton,et al.  Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and β-Actin mRNA in Dendrites and Spines of Hippocampal Neurons , 2003, The Journal of Neuroscience.

[11]  Vincent F. Castellucci,et al.  An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation , 2003, Nature Neuroscience.

[12]  M. Ehlers.  Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system , 2003, Nature Neuroscience.

[13]  B. Oostra,et al.  The Fragile X Syndrome Protein FMRP Associates with BC1 RNA and Regulates the Translation of Specific mRNAs at Synapses , 2003, Cell.

[14]  I. Weiler,et al.  RNA Cargoes Associating with FMRP Reveal Deficits in Cellular Functioning in Fmr1 Null Mice , 2003, Neuron.

[15]  M. Ehlers.  Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system , 2003, Nature neuroscience.

[16]  A. Iacoangeli,et al.  Dendritic BC1 RNA: Functional Role in Regulation of Translation Initiation , 2002, The Journal of Neuroscience.

[17]  O. Steward.  mRNA at Synapses, Synaptic Plasticity, and Memory Consolidation , 2002, Neuron.

[18]  M. Mayford,et al.  Disruption of Dendritic Translation of CaMKIIα Impairs Stabilization of Synaptic Plasticity and Memory Consolidation , 2002, Neuron.

[19]  A. Giuditta,et al.  Axonal and presynaptic protein synthesis: new insights into the biology of the neuron , 2002, Trends in Neurosciences.

[20]  N. Belluardo,et al.  Dendritic Localization of Mammalian neuralized mRNA Encoding a Protein with Transcription Repression Activities , 2002, Molecular and Cellular Neuroscience.

[21]  J. Fiala,et al.  Polyribosomes Redistribute from Dendritic Shafts into Spines with Enlarged Synapses during LTP in Developing Rat Hippocampal Slices , 2002, Neuron.

[22]  J. Flanagan,et al.  Axonal Protein Synthesis Provides a Mechanism for Localized Regulation at an Intermediate Target , 2002, Cell.

[23]  Mu-ming Poo,et al.  Adaptation in the chemotactic guidance of nerve growth cones , 2002, Nature.

[24]  Yi-shuian Huang,et al.  N‐methyl‐D‐aspartate receptor signaling results in Aurora kinase‐catalyzed CPEB phosphorylation and αCaMKII mRNA polyadenylation at synapses , 2002, The EMBO journal.

[25]  S. Shibata,et al.  A chromodomain-containing nuclear protein, MRG15 is expressed as a novel type of dendritic mRNA in neurons , 2002, Neuroscience Research.

[26]  C. Holt,et al.  Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation , 2001, Neuron.

[27]  M. Bear,et al.  A Role for the Cytoplasmic Polyadenylation Element in NMDA Receptor-Regulated mRNA Translation in Neurons , 2001, The Journal of Neuroscience.

[28]  K. Martin,et al.  A Functional Role for Intra-Axonal Protein Synthesis during Axonal Regeneration from Adult Sensory Neurons , 2001, The Journal of Neuroscience.

[29]  J. Darnell,et al.  Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function , 2001, Cell.

[30]  J. Eberwine,et al.  Identification of sites for exponential translation in living dendrites , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. M. Shenoy,et al.  Neurotrophin-Induced Transport of a β-Actin mRNP Complex Increases β-Actin Levels and Stimulates Growth Cone Motility , 2001, Neuron.

[32]  C. Goodman,et al.  Ubiquitination-dependent mechanisms regulate synaptic growth and function , 2001, Nature.

[33]  Thomas J. Carew,et al.  Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia , 2001, Neuron.

[34]  O. Steward,et al.  A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Erin M. Schuman,et al.  Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons , 2001, Neuron.

[36]  Linda Hicke,et al.  Ubiquitin and proteasomes: Protein regulation by monoubiquitin , 2001, Nature Reviews Molecular Cell Biology.

[37]  G M Edelman,et al.  Internal initiation of translation of five dendritically localized neuronal mRNAs , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Tessier-Lavigne,et al.  Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex , 2001, Science.

[39]  N. Syed,et al.  Local protein synthesis in invertebrate axons: from dogma to dilemma. , 2001, Results and problems in cell differentiation.

[40]  O. Steward,et al.  Protein synthesis at synaptic sites on dendrites. , 2001, Annual review of neuroscience.

[41]  J. Yewdell,et al.  Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[42]  P. Crino,et al.  Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Jaime Alvarez,et al.  Protein synthesis in axons and terminals: significance for maintenance, plasticity and regulation of phenotype With a critique of slow transport theory , 2000, Progress in Neurobiology.

[44]  M. Sheng,et al.  Growth of the NMDA receptor industrial complex , 2000, Nature Neuroscience.

[45]  S. Grant,et al.  Proteomic analysis of NMDA receptor–adhesion protein signaling complexes , 2000, Nature Neuroscience.

[46]  M. Kennedy,et al.  Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry , 2000, The Journal of Neuroscience.

[47]  L. Mannucci,et al.  Chemical Stimulation of Synaptosomes Modulates α-Ca2+/Calmodulin-Dependent Protein Kinase II mRNA Association to Polysomes , 2000, The Journal of Neuroscience.

[48]  M. Corbetta,et al.  Erratum to “Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines” , 2000, Nature Neuroscience.

[49]  J. D. McGaugh,et al.  Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines , 2000, Nature Neuroscience.

[50]  M. Constantine-Paton,et al.  NMDA receptor-mediated control of protein synthesis at developing synapses , 2000, Nature Neuroscience.

[51]  J. Sarvey,et al.  Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. , 2000, Brain research. Molecular brain research.

[52]  D. Richter,et al.  Somatostatin Receptor Interacting Protein Defines a Novel Family of Multidomain Proteins Present in Human and Rodent Brain* , 1999, The Journal of Biological Chemistry.

[53]  N. Hecht,et al.  The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites. , 1999, Journal of cell science.

[54]  R. Singer,et al.  Neurotrophin Regulation of β-Actin mRNA and Protein Localization within Growth Cones , 1999, The Journal of cell biology.

[55]  O. Steward,et al.  Lamina-Specific Synaptic Activation Causes Domain-Specific Alterations in Dendritic Immunostaining for MAP2 and CAM Kinase II , 1999, The Journal of Neuroscience.

[56]  M. Kennedy,et al.  Tetanic Stimulation Leads to Increased Accumulation of Ca2+/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons , 1999, The Journal of Neuroscience.

[57]  Hisashi Q. Higuchi.  On the nature of , 1999 .

[58]  Samuel Schacher,et al.  Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia , 1999, Neuron.

[59]  F. Bloom,et al.  RNA, Whither Goest Thou? , 1999, Science.

[60]  E. Quinlan,et al.  CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses , 1998, Neuron.

[61]  Gregor Eichele,et al.  Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation , 1998, Neuron.

[62]  Chou P Hung,et al.  A Role for the Cadherin Family of Cell Adhesion Molecules in Hippocampal Long-Term Potentiation , 1998, Neuron.

[63]  O. Steward,et al.  No evidence for disruption of normal patterns of mRNA localization in dendrites or dendritic transport of recently synthesized mRNA in FMR1 knockout mice, a model for human fragile‐X mental retardation syndrome , 1998, Neuroreport.

[64]  K. Kosik,et al.  Sorting of β-Actin mRNA and Protein to Neurites and Growth Cones in Culture , 1998, The Journal of Neuroscience.

[65]  P. Seeburg,et al.  Prominent Dendritic Localization in Forebrain Neurons of a Novel mRNA and Its Product, Dendrin , 1997, Molecular and Cellular Neuroscience.

[66]  E. Kandel,et al.  Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage , 1997, Cell.

[67]  K. Kosik,et al.  Neurotrophin-3 signals redistribute RNA in neurons. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[68]  E. Tongiorgi,et al.  Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons , 1997, The Journal of Neuroscience.

[69]  O. Steward,et al.  Multiple subcellular mRNA distribution patterns in neurons: a nonisotopic in situ hybridization analysis. , 1997, Journal of neurobiology.

[70]  I. Weiler,et al.  Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[71]  James H. Schwartz,et al.  Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia , 1997, Cell.

[72]  D. Benson.  Dendritic compartmentation of NMDA receptor mRNA in cultured hippocampal neurons , 1997, Neuroreport.

[73]  A. Triller,et al.  Dendritic and Postsynaptic Localizations of Glycine Receptor α Subunit mRNAs , 1997, The Journal of Neuroscience.

[74]  E. Mohr,et al.  Dendritic Localization of Rat Vasopressin mRNA: Ultrastructural Analysis and Mapping of Targeting Elements , 1997, The European journal of neuroscience.

[75]  S. Hersch,et al.  Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes , 1997, The Journal of Neuroscience.

[76]  M. Lalande,et al.  UBE3A/E6-AP mutations cause Angelman syndrome , 1996, Nature Genetics.

[77]  T. Deerinck,et al.  Translocation of RNA Granules in Living Neurons , 1996, The Journal of Neuroscience.

[78]  J. Brosius,et al.  Translational Machinery in Dendrites of Hippocampal Neurons in Culture , 1996, Journal of Neuroscience.

[79]  O. Steward,et al.  Protein Synthesis within Dendrites: Glycosylation of Newly Synthesized Proteins in Dendrites of Hippocampal Neurons in Culture , 1996, The Journal of Neuroscience.

[80]  I. Brown,et al.  CaM I mRNA is localized to apical dendrites during postnatal development of neurons in the rat brain , 1996, Journal of neuroscience research.

[81]  K. Schilling,et al.  Differential mRNA Transport and the Regulation of Protein Synthesis: Selective Sensitivity of Purkinje Cell Dendritic mRNAs to Translational Inhibition , 1996, Molecular and Cellular Neuroscience.

[82]  O. Steward,et al.  Ultrastructural basis for gene expression at the synapse: synapse-associated polyribosome complexes , 1996, Journal of neurocytology.

[83]  U. Frey,et al.  Somatodendritic expression of an immediate early gene is regulated by synaptic activity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[84]  Carol A Barnes,et al.  Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites , 1995, Neuron.

[85]  Linda B. Buck,et al.  Information coding in the olfactory system: Evidence for a stereotyped and highly organized epitope map in the olfactory bulb , 1994, Cell.

[86]  Richard Axel,et al.  Topographic organization of sensory projections to the olfactory bulb , 1994, Cell.

[87]  J. Eberwine,et al.  On the nature and differential distribution of mRNAs in hippocampal neurites: implications for neuronal functioning. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[88]  M. Erlander,et al.  G‐protein γ7 subunit is selectively expressed in medium‐sized neurons and dendrites of the rat neostriatum , 1994 .

[89]  S. J. Smith,et al.  Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities , 1994, Neuroscience Letters.

[90]  M. Scheffner,et al.  The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53 , 1993, Cell.

[91]  D. Terrian,et al.  mRNA at the synapse: analysis of a synaptosomal preparation enriched in hippocampal dendritic spines , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[92]  I. Weiler,et al.  Metabotropic glutamate receptors trigger postsynaptic protein synthesis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[93]  J. Perlin,et al.  Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[94]  A Miyawaki,et al.  Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. , 1993, Receptors & channels.

[95]  David E. Housman,et al.  Tissue specific expression of FMR–1 provides evidence for a functional role in fragile X syndrome , 1993, Nature Genetics.

[96]  Richard F. Thompson,et al.  BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity , 1992, Neuron.

[97]  O. Steward,et al.  Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[98]  O. Steward,et al.  Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[99]  D. Richter,et al.  Axonal transport of neuropeptide encoding mRNAs within the hypothalamo‐hypophyseal tract of rats. , 1991, The EMBO journal.

[100]  J. Brosius,et al.  Dendritic location of neural BC1 RNA. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[101]  M. Waxham,et al.  In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[102]  A. Matus,et al.  Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites , 1988, Nature.

[103]  O. Steward,et al.  Protein-synthetic machinery beneath postsynaptic sites on CNS neurons: association between polyribosomes and other organelles at the synaptic site , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[104]  O. Steward,et al.  Polyribosomes associated with synaptic specializations on axon initial segments: localization of protein-synthetic machinery at inhibitory synapses , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[105]  O. Steward,et al.  Protein-synthetic machinery at postsynaptic sites during synaptogenesis: a quantitative study of the association between polyribosomes and developing synapses , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[106]  O. Steward.  Polyribosomes at the base of dendritic spines of central nervous system neurons--their possible role in synapse construction and modification. , 1983, Cold Spring Harbor symposia on quantitative biology.

[107]  O. Steward,et al.  Polyribosomes associated with dendritic spines in the denervated dentate gyrus: evidence for local regulation of protein synthesis during reinnervation. , 1983, Progress in brain research.

[108]  W. Levy,et al.  Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[109]  H. Kröger,et al.  [Protein synthesis]. , 1974, Fortschritte der Medizin.

[110]  V. Tennyson.  THE FINE STRUCTURE OF THE AXON AND GROWTH CONE OF THE DORSAL ROOT NEUROBLAST OF THE RABBIT EMBRYO , 1970, The Journal of cell biology.