Cloning and characterization of a functional promoter of the human SOCS-3 gene

[1]  J. Herman,et al.  SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. , 2003, Blood.

[2]  J. Pow-Sang,et al.  Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. , 2002, Cancer research.

[3]  J. Darnell,et al.  Signalling: STATs: transcriptional control and biological impact , 2002, Nature Reviews Molecular Cell Biology.

[4]  D. Hilton,et al.  SOCS Proteins: Negative Regulators of Cytokine Signaling , 2001, Stem cells.

[5]  J. Herman,et al.  SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity , 2001, Nature Genetics.

[6]  J. Turkson,et al.  Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. , 2001, The Journal of clinical investigation.

[7]  Jiayuh Lin,et al.  Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. , 2000, Gynecologic oncology.

[8]  C. Paul,et al.  Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. , 2000, European journal of biochemistry.

[9]  M. Fujimoto,et al.  IFN Regulatory Factor-1-Mediated Transcriptional Activation of Mouse STAT-Induced STAT Inhibitor-1 Gene Promoter by IFN-γ1 , 2000, The Journal of Immunology.

[10]  E. Van Obberghen,et al.  SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling* , 2000, The Journal of Biological Chemistry.

[11]  P. Coffer,et al.  The role of STATs in myeloid differentiation and leukemia , 2000, Oncogene.

[12]  W. Leonard,et al.  The role of Stat5a and Stat5b in signaling by IL-2 family cytokines , 2000, Oncogene.

[13]  J. Grandis,et al.  STAT signaling in head and neck cancer , 2000, Oncogene.

[14]  Roy Garcia,et al.  STATs in oncogenesis , 2000, Oncogene.

[15]  R. Wilkins,et al.  STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver , 1999, Molecular and Cellular Endocrinology.

[16]  R. Jove,et al.  STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. , 1999, Current opinion in oncology.

[17]  S. Melmed,et al.  Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[18]  G. Stark,et al.  How cells respond to interferons. , 1998, Annual review of biochemistry.

[19]  W. Alexander,et al.  Twenty proteins containing a C-terminal SOCS box form five structural classes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Darnell.  STATs and gene regulation. , 1997, Science.

[21]  J. O’Shea.  Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? , 1997, Immunity.

[22]  S. Akira,et al.  Structure and function of a new STAT-induced STAT inhibitor , 1997, Nature.