Corneal latency and transmission of herpes simplex virus-1.

The transmission of herpes simplex virus (HSV)-1 by corneal transplantation has rarely been reported. It is believed that these cases have resulted either from reactivated virus traveling from the trigeminal ganglion to the cornea or from latent HSV-1 in the donor cornea itself. Studies of long-term viral presence in corneal tissue have sought to determine whether there is evidence of true non-neuronal latency, although there are problems in its definition. Recent studies provide new insights into neuronal latency, while similar HSV-1 gene regulation in the cornea may implicate corneal latency in pathophysiology and as a potential risk for transplant recipients. This issue has led to concerns over eye banking, which currently screens for other infectious agents but not HSV-1. Here we review the literature regarding corneal latency and the transmission of HSV-1.

[1]  W. Halford,et al.  ICP0 Antagonizes ICP4-Dependent Silencing of the Herpes Simplex Virus ICP0 Gene , 2010, PloS one.

[2]  H. Friedman,et al.  Anterograde Spread of Herpes Simplex Virus Type 1 Requires Glycoprotein E and Glycoprotein I but Not Us9 , 2009, Journal of Virology.

[3]  A. Osterhaus,et al.  Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues. , 2009, The Journal of infectious diseases.

[4]  James M. Hill,et al.  Herpes simplex virus type 1 DNA in human corneas: what are the virological and clinical implications? , 2009, The Journal of infectious diseases.

[5]  James M. Hill,et al.  Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locus. , 2009, Investigative ophthalmology & visual science.

[6]  N. Sawtell,et al.  De Novo Synthesis of VP16 Coordinates the Exit from HSV Latency In Vivo , 2009, PLoS pathogens.

[7]  S. Wechsler,et al.  Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+ T Cells in Trigeminal Ganglia of Latently Infected Mice , 2008, Journal of Virology.

[8]  P. Kalinski,et al.  Reevaluating the CD8 T-Cell Response to Herpes Simplex Virus Type 1: Involvement of CD8 T Cells Reactive to Subdominant Epitopes , 2008, Journal of Virology.

[9]  C. Baty,et al.  Noncytotoxic Lytic Granule–Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency , 2008, Science.

[10]  T. Valyi-Nagy,et al.  HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium. , 2008, Investigative ophthalmology & visual science.

[11]  U. Pleyer,et al.  The Survival of Herpes Simplex Virus in Preserved Murine Corneas , 2008, Ophthalmic Research.

[12]  M. Ball,et al.  The High Prevalence of Herpes Simplex Virus Type 1 DNA in Human Trigeminal Ganglia Is Not a Function of Age or Gender , 2008, Journal of Virology.

[13]  B. Yue,et al.  Herpes simplex virus type 2 entry into cultured human corneal fibroblasts is mediated by herpesvirus entry mediator. , 2007, The Journal of general virology.

[14]  A. Kalkan,et al.  The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons , 2007, Clinical ophthalmology.

[15]  K. Hayashi,et al.  Corneal Buttons Obtained From Patients With HSK Harbor High Copy Numbers of the HSV Genome , 2007, Cornea.

[16]  B. Galen,et al.  Access to Nectin Favors Herpes Simplex Virus Infection at the Apical Surface of Polarized Human Epithelial Cells , 2006, Journal of Virology.

[17]  O. Damour,et al.  Major endothelial loss from corneas in organ culture: importance of second endothelial count. , 2006, Cornea.

[18]  S Louise Moffatt,et al.  Centennial review of corneal transplantation , 2005, Clinical & experimental ophthalmology.

[19]  P. Garg,et al.  The value of corneal transplantation in reducing blindness , 2005, Eye.

[20]  B. Rouse,et al.  Herpes keratitis in the absence of anterograde transport of virus from sensory ganglia to the cornea. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  N. Fraser,et al.  Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis , 2005, Journal of Virology.

[22]  E. Miserocchi,et al.  Comparison of the Efficacy of Valacyclovir vs Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease , 2005 .

[23]  James M. Hill,et al.  HSV-1 DNA in tears and saliva of normal adults. , 2005, Investigative ophthalmology & visual science.

[24]  F. Rozenberg,et al.  Culture-Proven Herpetic Keratitis After Penetrating Keratoplasty in Patients With No Previous History of Herpes Disease , 2004, Cornea.

[25]  E. Cohen,et al.  New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty. , 2004, American journal of ophthalmology.

[26]  P. Gain,et al.  Ultrastructural demonstration of replicative herpes simplex virus type 1 transmission through corneal graft. , 2004, Transplantation.

[27]  P. Robert,et al.  Herpes simplex virus DNA in corneal transplants: Prospective study of 38 recipients , 2003, Journal of medical virology.

[28]  P. Kinchington,et al.  Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. , 2003, Immunity.

[29]  J. Glorioso,et al.  The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells , 2003, Journal of Virology.

[30]  Xiaodong Zheng.  Reactivation and Donor‐Host Transmission of Herpes Simplex Virus After Corneal Transplantation , 2002, Cornea.

[31]  G. Cockerham.  Primary graft failure caused by herpes simplex virus type 1. , 2001, Cornea.

[32]  T. Zeyen,et al.  Primary Graft Failure Caused by Herpes Simplex Virus Type 1 , 2001, Cornea.

[33]  A. Osterhaus,et al.  Herpes simplex virus 1 transmission through corneal transplantation , 2001, The Lancet.

[34]  G. Cockerham,et al.  Primary graft failure : a clinicopathologic and molecular analysis. , 2000, Ophthalmology.

[35]  A. van der Lelij,et al.  Detection of herpes simplex virus type 1, 2 and varicella zoster virus DNA in recipient corneal buttons , 2000, The British journal of ophthalmology.

[36]  W. Chu,et al.  The Past Twenty-five Years in Eye Banking , 2000, Cornea.

[37]  G. Corbitt,et al.  Graft failure in human donor corneas due to transmission of herpes simplex virus , 2000, The British journal of ophthalmology.

[38]  D. Easty,et al.  Human herpesviruses in the cornea , 2000, The British journal of ophthalmology.

[39]  A. Nesburn,et al.  Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring , 2000, The British journal of ophthalmology.

[40]  A. Nesburn,et al.  Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. , 2000, Science.

[41]  H. Kaufman,et al.  HSV-1 migration in latently infected and naive rabbits after penetrating keratoplasty. , 1999, Investigative ophthalmology & visual science.

[42]  W. O'brien,et al.  Tissue-specific accumulation of latency-associated transcripts in herpes virus-infected rabbits. , 1998, Investigative ophthalmology & visual science.

[43]  R. D. Stulting,et al.  Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. , 1998, The New England journal of medicine.

[44]  G. Cockerham,et al.  Herpes simplex virus in primary graft failure. , 1997, Archives of ophthalmology.

[45]  P. Doornenbal,et al.  Newly acquired herpes simplex virus keratitis after penetrating keratoplasty. , 1997, Ophthalmology.

[46]  P. Klapper,et al.  Detection of herpes simplex virus DNA in donor cornea culture medium by polymerase chain reaction. , 1996, The British journal of ophthalmology.

[47]  D. Easty,et al.  Recurrent herpes simplex after corneal transplantation in rats. , 1996, Investigative ophthalmology & visual science.

[48]  J. Niland,et al.  Herpes simplex Virus dna in normal corneas: Persistence without viral shedding from ganglia , 1995, Journal of medical virology.

[49]  T. Møller-Pedersen,et al.  Corneal storage and complications related to grafting , 1994, Current Opinion in Ophthalmology.

[50]  P. Klapper,et al.  Corneal Donor Infection by Herpes Simplex Virus: Herpes Simplex Virus DNA in Donor Corneas , 1994, Cornea.

[51]  A. Nesburn,et al.  Similarities in regulation of the HSV-1 LAT promoter in corneal and neuronal cells. , 1994, Investigative ophthalmology & visual science.

[52]  R. D. Stulting,et al.  Herpes simplex virus type 1 transcription is not detectable in quiescent human stromal keratitis by in situ hybridization. , 1993, Investigative ophthalmology & visual science.

[53]  Stulting Rd,et al.  Detection of herpes simplex virus type 1 latency-associated transcripts in corneal cells of inbred mice by in situ hybridization. , 1992 .

[54]  R. D. Stulting,et al.  Detection of Herpes Simplex Virus Type 1 Latency—Associated Transcripts in Corneal Cells of Inbred Mice by In Situ Hybridization , 1992, Cornea.

[55]  E. Pels,et al.  Clinical comparison of grafts stored in McCarey-Kaufman medium at 4 degrees C and in corneal organ culture at 31 degrees C. , 1992, Archives of ophthalmology.

[56]  R. Laing,et al.  Optisol corneal storage medium. , 1991, American journal of ophthalmology.

[57]  N. Maitland,et al.  Latency-associated transcripts in corneas and ganglia of HSV-1 infected rabbits. , 1991, The British journal of ophthalmology.

[58]  A. Nesburn,et al.  Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1). , 1991, Virology.

[59]  J. Cherry,et al.  Detection of herpes simplex virus thymidine kinase and latency-associated transcript gene sequences in human herpetic corneas by polymerase chain reaction amplification. , 1991, Investigative ophthalmology & visual science.

[60]  S. Kaye,et al.  Evidence for herpes simplex viral latency in the human cornea. , 1991, The British journal of ophthalmology.

[61]  E. Romanowski,et al.  HSV-1 corneal latency. , 1991, Investigative ophthalmology & visual science.

[62]  L. Melton,et al.  Epidemiology of ocular herpes simplex. Incidence in Rochester, Minn, 1950 through 1982. , 1989, Archives of ophthalmology.

[63]  K. Tyler,et al.  Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency , 1989, Journal of virology.

[64]  K. Bean,et al.  Detection of HSV nucleic acid sequences in the cornea during acute and latent ocular disease. , 1988, Experimental eye research.

[65]  E. Lavi,et al.  Latent herpes simplex virus type 1 transcription in human trigeminal ganglia , 1988, Journal of virology.

[66]  R. D. Stulting,et al.  Recovery of herpes simplex virus from ocular tissues of latently infected inbred mice. , 1988, Investigative ophthalmology & visual science.

[67]  S. Brown,et al.  Recovery of herpes simplex virus from the corneas of experimentally infected rabbits. , 1987, The Journal of general virology.

[68]  E. Wagner,et al.  RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. , 1987, Science.

[69]  D. Easty,et al.  Herpes simplex virus isolation in chronic stromal keratitis: human and laboratory studies. , 1987, Current eye research.

[70]  P. Klapper,et al.  Herpesvirus simplex in chronic human stromal keratitis. , 1986, Current eye research.

[71]  S. Brown,et al.  Herpes simplex virus type 1 persistence and latency in cultured rabbit corneal epithelial cells, keratocytes, and endothelial cells. , 1986, The British journal of ophthalmology.

[72]  D. Easty,et al.  Isolation of herpes simplex virus from corneal discs of patients with chronic stromal keratitis. , 1985, Transactions of the ophthalmological societies of the United Kingdom.

[73]  H. E. Kaufman,et al.  Herpes simplex keratitis. , 1983, Ophthalmology.

[74]  D. Easty,et al.  Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. , 1982, The British journal of ophthalmology.

[75]  A. S. Wiener,et al.  Transplantation , 1963 .