Extracellular vesicles: biology and emerging therapeutic opportunities

[1]  S. Lim,et al.  Exosomes for drug delivery - a novel application for the mesenchymal stem cell. , 2013, Biotechnology advances.

[2]  M. Wood,et al.  Exosomes for targeted siRNA delivery across biological barriers. , 2013, Advanced drug delivery reviews.

[3]  S. Lim,et al.  Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. , 2013, Advanced drug delivery reviews.

[4]  G. Camussi,et al.  Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth. , 2013, Stem cells and development.

[5]  Mehmet Fatih Bolukbasi,et al.  Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[6]  Shinobu Ueda,et al.  Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[7]  M. Wood,et al.  Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. , 2012, Human molecular genetics.

[8]  E. Sverdlov Amedeo Avogadro's cry: What is 1 µg of exosomes? , 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

[9]  F. Reyal,et al.  Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. , 2012, Cancer research.

[10]  Julia Christina Gross,et al.  Active Wnt proteins are secreted on exosomes , 2012, Nature Cell Biology.

[11]  G. Camussi,et al.  Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells. , 2012, Kidney international.

[12]  G. Camussi,et al.  Therapeutic potential of mesenchymal stem cell-derived microvesicles. , 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[13]  James W. Clancy,et al.  Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. , 2012, Genes & development.

[14]  Xuetao Cao,et al.  Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway , 2012, The Journal of Immunology.

[15]  Ylva Ivarsson,et al.  Syndecan–syntenin–ALIX regulates the biogenesis of exosomes , 2012, Nature Cell Biology.

[16]  G. Camussi,et al.  Microvesicles Derived from Endothelial Progenitor Cells Enhance Neoangiogenesis of Human Pancreatic Islets , 2012, Cell transplantation.

[17]  A. Guha,et al.  Extracellular vesicles – vehicles that spread cancer genes , 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

[18]  M. Tendera,et al.  Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? , 2012, Leukemia.

[19]  Gema Moreno-Bueno,et al.  Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.

[20]  R. Sadoul,et al.  Emerging Role of Neuronal Exosomes in the Central Nervous System , 2012, Front. Physio..

[21]  Per Sunnerhagen,et al.  Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes , 2012, Nucleic acids research.

[22]  X. Breakefield,et al.  Microvesicle-associated AAV vector as a novel gene delivery system. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[23]  X. Breakefield,et al.  Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies , 2012, Front. Physio..

[24]  Andrew F. Hill,et al.  Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases? , 2012, Front. Physio..

[25]  G. Camussi,et al.  Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury , 2012, PloS one.

[26]  J. Nolta,et al.  Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin , 2012, Molecular and Cellular Neuroscience.

[27]  Stanley N Cohen,et al.  Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein , 2012, Proceedings of the National Academy of Sciences.

[28]  Ling Huang,et al.  Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. , 2012, Cancer letters.

[29]  Jian-Bing Fan,et al.  miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles , 2012, Molecular therapy. Nucleic acids.

[30]  Simon C Watkins,et al.  Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. , 2012, Blood.

[31]  P. Quesenberry,et al.  Stable cell fate changes in marrow cells induced by lung-derived microvesicles , 2012, Journal of extracellular vesicles.

[32]  R. Schiffelers,et al.  Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes , 2012, Journal of extracellular vesicles.

[33]  J. Kwekkeboom,et al.  Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi) , 2011, Gut.

[34]  Clotilde Théry,et al.  Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses , 2011, Traffic.

[35]  Dongmei Sun,et al.  Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[36]  F. Su,et al.  Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells , 2011, Molecular Cancer.

[37]  Hamid Cheshmi Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers , 2011 .

[38]  S. Lim,et al.  Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. , 2011, Regenerative medicine.

[39]  M. Goumans,et al.  Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. , 2011, Stem cell research.

[40]  G. Camussi,et al.  Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[41]  Fátima Sánchez-Cabo,et al.  Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells , 2011, Nature communications.

[42]  M. Wood,et al.  Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes , 2011, Nature Biotechnology.

[43]  L. Mincheva-Nilsson,et al.  Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells , 2011, PloS one.

[44]  Shunsuke Noguchi,et al.  Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[45]  G. Lachenal,et al.  Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity , 2011, Molecular and Cellular Neuroscience.

[46]  Ciro Tetta,et al.  Exosome/microvesicle-mediated epigenetic reprogramming of cells. , 2011, American journal of cancer research.

[47]  Clotilde Théry,et al.  Exosomes: immune properties and potential clinical implementations , 2011, Seminars in Immunopathology.

[48]  S. Lim,et al.  Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs , 2011, Journal of Translational Medicine.

[49]  P. Quesenberry,et al.  Cellular phenotype switching and microvesicles. , 2010, Advanced drug delivery reviews.

[50]  A. Harris,et al.  New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. , 2010, Blood.

[51]  Dongmei Sun,et al.  A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[52]  Luca Sterpone,et al.  Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs , 2010, PloS one.

[53]  T. Whiteside,et al.  Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg) , 2010, PloS one.

[54]  Jing Li,et al.  Secreted monocytic miR-150 enhances targeted endothelial cell migration. , 2010, Molecular cell.

[55]  M. Ntzouni,et al.  Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival , 2010, The Journal of Neuroscience.

[56]  Gerard Pasterkamp,et al.  Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. , 2010, Stem cell research.

[57]  W. Möbius,et al.  Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C , 2010, The Journal of cell biology.

[58]  T. D. de Gruijl,et al.  Functional delivery of viral miRNAs via exosomes , 2010, Proceedings of the National Academy of Sciences.

[59]  M. Kuehn,et al.  Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles , 2010, Microbiology and Molecular Biology Reviews.

[60]  K. Preissner,et al.  Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. , 2010, Cancer research.

[61]  B. Chauffert,et al.  Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. , 2010, The Journal of clinical investigation.

[62]  G. Camussi,et al.  Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats , 2009, Journal of cellular and molecular medicine.

[63]  Miguel C. Seabra,et al.  Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.

[64]  Graca Raposo,et al.  ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles , 2009, Current Biology.

[65]  M. Barcinski,et al.  Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner. , 2009, Cancer letters.

[66]  Carmen Visus,et al.  Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes1 , 2009, The Journal of Immunology.

[67]  O. Voinnet,et al.  Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity , 2009, Nature Cell Biology.

[68]  C. Théry,et al.  Membrane vesicles as conveyors of immune responses , 2009, Nature Reviews Immunology.

[69]  Genevieve DeMaria,et al.  Characterization of exosome‐like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[70]  Alessandro Busca,et al.  Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. , 2009, Journal of the American Society of Nephrology : JASN.

[71]  Massimo Spada,et al.  High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients , 2009, PloS one.

[72]  Harald Stenmark,et al.  The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins , 2009, Nature.

[73]  R. Kerbel,et al.  Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR , 2009, Proceedings of the National Academy of Sciences.

[74]  Michele Guescini,et al.  Astrocytes and Glioblastoma cells release exosomes carrying mtDNA , 2009, Journal of Neural Transmission.

[75]  A. Engert,et al.  Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function , 2008, PloS one.

[76]  A. Ghahary,et al.  Primary human keratinocytes externalize stratifin protein via exosomes , 2008, Journal of cellular biochemistry.

[77]  M. Mason,et al.  Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression1 , 2008, The Journal of Immunology.

[78]  T. Ratliff,et al.  Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. , 2008, Blood.

[79]  A. Guha,et al.  Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells , 2008, Nature Cell Biology.

[80]  C. Steinem,et al.  Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages1 , 2008, The Journal of Immunology.

[81]  Petra Schwille,et al.  Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes , 2008, Science.

[82]  C. Hess,et al.  Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells1 , 2008, The Journal of Immunology.

[83]  P. Doevendans,et al.  Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. , 2008, Stem cell research.

[84]  K. Węglarczyk,et al.  Tumour-derived microvesicles modulate biological activity of human monocytes. , 2007, Immunology letters.

[85]  Luigi Biancone,et al.  Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. , 2007, Blood.

[86]  P. Quesenberry,et al.  Alteration of Marrow Cell Gene Expression, Protein Production, and Engraftment into Lung by Lung‐Derived Microvesicles: A Novel Mechanism for Phenotype Modulation , 2007, Stem cells.

[87]  Sanchita Bhatnagar,et al.  Exosomes Released from Infected Macrophages Contain Mycobacterium avium Glycopeptidolipids and Are Proinflammatory* , 2007, Journal of Biological Chemistry.

[88]  Aled Clayton,et al.  Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. , 2007, Cancer research.

[89]  William E. Grizzle,et al.  Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells1 , 2007, The Journal of Immunology.

[90]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[91]  R. Cappai,et al.  Packaging of prions into exosomes is associated with a novel pathway of PrP processing , 2007, The Journal of pathology.

[92]  Vincenza Dolo,et al.  Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells. , 2007, Neoplasia.

[93]  R. Bertina,et al.  Microparticle‐associated tissue factor activity: a link between cancer and thrombosis? , 2007, Journal of thrombosis and haemostasis : JTH.

[94]  J Ratajczak,et al.  Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery , 2006, Leukemia.

[95]  J. Ingwall,et al.  Evidence supporting paracrine hypothesis for Akt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[96]  G. Lachenal,et al.  Exosomes are released by cultured cortical neurones , 2006, Molecular and Cellular Neuroscience.

[97]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[98]  William E. Grizzle,et al.  Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function1 , 2006, The Journal of Immunology.

[99]  M. Ratajczak,et al.  Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes , 2006, Cancer Immunology, Immunotherapy.

[100]  José A López,et al.  Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. , 2005, Blood.

[101]  L. Santambrogio,et al.  Proteomic Analysis of Microglia-Derived Exosomes: Metabolic Role of the Aminopeptidase CD13 in Neuropeptide Catabolism1 , 2005, The Journal of Immunology.

[102]  C. Gross,et al.  Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. , 2005, Cancer research.

[103]  Simon C Watkins,et al.  Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis 1 , 2005, The Journal of Immunology.

[104]  J. Ingwall,et al.  Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells , 2005, Nature Medicine.

[105]  M. T. Damiani,et al.  Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium‐Dependent Manner , 2005, Traffic.

[106]  Simon C Watkins,et al.  Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[107]  S. Baylin,et al.  Hematopoietic stem cells convert into liver cells within days without fusion , 2004, Nature Cell Biology.

[108]  J. Lavail,et al.  The microvesicle as a vehicle for EMMPRIN in tumor–stromal interactions , 2004, Oncogene.

[109]  J. Le Pecq,et al.  Production and characterization of clinical grade exosomes derived from dendritic cells. , 2002, Journal of immunological methods.

[110]  D. Praticò,et al.  Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. , 2002, Experimental hematology.

[111]  M. Martínez-Lorenzo,et al.  Differential Secretion of Fas Ligand- or APO2 Ligand/TNF-Related Apoptosis-Inducing Ligand-Carrying Microvesicles During Activation-Induced Death of Human T Cells1 , 2001, The Journal of Immunology.

[112]  H. Brühl,et al.  Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection , 2000, Nature Medicine.

[113]  T. Beveridge Structures of Gram-Negative Cell Walls and Their Derived Membrane Vesicles , 1999, Journal of bacteriology.

[114]  Laurence Zitvogel,et al.  Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes , 1998, Nature Medicine.

[115]  C. Melief,et al.  B lymphocytes secrete antigen-presenting vesicles , 1996, The Journal of experimental medicine.

[116]  T. Lentz Rabies virus binding to an acetylcholine receptor α‐subunit peptide , 1990 .

[117]  C. Harding,et al.  Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. , 1984, European journal of cell biology.

[118]  B. Pan,et al.  Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor , 1983, Cell.

[119]  H. Dvorak,et al.  Tumor shedding and coagulation. , 1981, Science.

[120]  S. Chatterjee,et al.  Electron microscopic observations on the excretion of cell-wall material by Vibrio cholerae. , 1967, Journal of general microbiology.