The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity
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[1] Jing Yang,et al. Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics , 2022, Seminars in cancer biology.
[2] Allison M. Porman,et al. A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells , 2022, PLoS biology.
[3] L. Kristensen,et al. Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications , 2022, Journal of Experimental & Clinical Cancer Research.
[4] X. Zhi,et al. HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer , 2022, Cell Death Discovery.
[5] Hongchuan Jin,et al. RNA-based therapeutics: an overview and prospectus , 2022, Cell Death & Disease.
[6] Wenxing He,et al. LncRNA HOTAIR promotes the proliferation and invasion/metastasis of breast cancer cells by targeting the miR-130a-3p/Suv39H1 axis , 2022, Biochemistry and biophysics reports.
[7] Soo-Jeong Cho,et al. Tumorigenic mechanisms of estrogen and Helicobacter pylori cytotoxin-associated gene A in estrogen receptor α-positive diffuse-type gastric adenocarcinoma , 2022, Gastric Cancer.
[8] C. Zheng,et al. Revisiting IRF1-mediated antiviral innate immunity. , 2022, Cytokine & growth factor reviews.
[9] Weipei Zhu,et al. LncRNA HOTAIR Promotes Chemoresistance by Facilitating Epithelial to Mesenchymal Transition through miR-29b/PTEN/PI3K Signaling in Cervical Cancer , 2021, Cells Tissues Organs.
[10] Lidong Wang,et al. MiR-613 inhibits the proliferation, migration, and invasion of papillary thyroid carcinoma cells by directly targeting TAGLN2 , 2021, Cancer cell international.
[11] Lidong Wang,et al. MiR-613 inhibits the proliferation, migration, and invasion of papillary thyroid carcinoma cells by directly targeting TAGLN2 , 2021, Cancer Cell International.
[12] T. Brabletz,et al. Dynamic EMT: a multi‐tool for tumor progression , 2021, The EMBO journal.
[13] Jianjun Chen,et al. Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation , 2021, Trends in genetics : TIG.
[14] M. Fabbri,et al. Noncoding RNA therapeutics — challenges and potential solutions , 2021, Nature reviews. Drug discovery.
[15] Beth K. Martin,et al. Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states. , 2021, Cancer cell.
[16] Shuling Guo,et al. HOTAIR lncRNA promotes epithelial–mesenchymal transition by redistributing LSD1 at regulatory chromatin regions , 2021, EMBO reports.
[17] Aaron M. Johnson,et al. Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity , 2021, Science Advances.
[18] Yun Xiao,et al. miR-454-3p inhibits non-small cell lung cancer cell proliferation and metastasis by targeting TGFB2 , 2021, Oncology reports.
[19] Maite Huarte,et al. Gene regulation by long non-coding RNAs and its biological functions , 2020, Nature reviews. Molecular cell biology.
[20] T. Rasmussen,et al. lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions. , 2020, Seminars in cancer biology.
[21] M. Shamsara,et al. Metformin modulates oncogenic expression of HOTAIR gene via promoter methylation and reverses epithelial–mesenchymal transition in MDA‐MB‐231 cells , 2020, Journal of cellular biochemistry.
[22] Giangaetano Tartaglia,et al. Design and Functional Validation of a Mutant Variant of the LncRNA HOTAIR to Counteract Snail Function in Epithelial-to-Mesenchymal Transition , 2020, Cancer Research.
[23] Yuanwen Chen,et al. HOTAIR contributes to the carcinogenesis of gastric cancer via modulating cellular and exosomal miRNAs level , 2020, Cell Death & Disease.
[24] A. Rustgi,et al. EMT, MET, Plasticity, and Tumor Metastasis. , 2020, Trends in cell biology.
[25] Lei Chen,et al. LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1 , 2020, Gastric Cancer.
[26] Chang Hoon Shin,et al. MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer , 2020, British Journal of Cancer.
[27] Jian-yun Zhu,et al. Hsa_circRNA_102610 upregulation in Crohn’s disease promotes transforming growth factor-β1-induced epithelial-mesenchymal transition via sponging of hsa-miR-130a-3p , 2020, World journal of gastroenterology.
[28] Yangchun Xie,et al. The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer , 2020, BMC Cancer.
[29] F. Zheng,et al. Novel regulation of miR‐34a‐5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer , 2020, Journal of cellular and molecular medicine.
[30] Cuiping Yang,et al. miR‐200c overexpression inhibits the invasion and tumorigenicity of epithelial ovarian cancer cells by suppressing lncRNA HOTAIR in mice , 2020, Journal of cellular biochemistry.
[31] Yusheng Wang,et al. LncRNA XIST knockdown suppresses the malignancy of human nasopharyngeal carcinoma through XIST/miRNA-148a-3p/ADAM17 pathway in vitro and in vivo. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[32] D. Xiao,et al. Exosomes-Derived Long Non-Coding RNA HOTAIR Reduces Laryngeal Cancer Radiosensitivity by Regulating microRNA-454-3p/E2F2 Axis , 2019, OncoTargets and therapy.
[33] Minghui Wang,et al. CCL18-induced HOTAIR upregulation promotes malignant progression in esophageal squamous cell carcinoma through the miR-130a-5p-ZEB1 axis. , 2019, Cancer letters.
[34] A. Marchetti,et al. TGFβ Impairs HNF1α Functional Activity in Epithelial-to-Mesenchymal Transition Interfering With the Recruitment of CBP/p300 Acetyltransferases , 2019, Front. Pharmacol..
[35] Shao-Chun Wang,et al. Long non-coding RNA HOTAIR in circulatory exosomes is correlated with ErbB2/HER2 positivity in breast cancer. , 2019, Breast.
[36] Chuan He,et al. Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. , 2019, Molecular cell.
[37] W. Lu,et al. Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis. , 2019, Developmental cell.
[38] Ling-Ling Chen,et al. Cellular functions of long noncoding RNAs , 2019, Nature Cell Biology.
[39] Xiaodong Zhang,et al. Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma , 2019, Molecular Cancer.
[40] Jianhua Wang,et al. Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression , 2019, Molecular Cancer.
[41] C. Blanpain,et al. EMT Transition States during Tumor Progression and Metastasis. , 2019, Trends in cell biology.
[42] C. Kang,et al. Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2 , 2019, Clinical Epigenetics.
[43] L. Yin,et al. miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells , 2019, Cancer medicine.
[44] Liling Tang,et al. MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer , 2019, Journal of experimental & clinical cancer research : CR.
[45] Aoran Guan,et al. Long non‐coding RNA Hotair promotes gastric cancer progression via miR‐217‐GPC5 axis , 2019, Life sciences.
[46] C. Cicchini,et al. Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression , 2018, Journal of clinical medicine.
[47] N. Brockdorff,et al. Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation , 2018, bioRxiv.
[48] Yida Pan,et al. H19/miR‐148a/USP4 axis facilitates liver fibrosis by enhancing TGF‐β signaling in both hepatic stellate cells and hepatocytes , 2018, Journal of cellular physiology.
[49] Yu Zheng,et al. MiR-454-3p and miR-374b-5p suppress migration and invasion of bladder cancer cells through targetting ZEB2 , 2018, Bioscience reports.
[50] Y. You,et al. H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma , 2018, Cellular Physiology and Biochemistry.
[51] F. Gonzalez,et al. The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation , 2018, Cell Death & Differentiation.
[52] Wei Ma,et al. Anti-tumor effect of HOTAIR–miR-613-SNAI2 axis through suppressing EMT and drug resistance in laryngeal squamous cell carcinoma , 2018, RSC advances.
[53] K. Weeks,et al. Principles for targeting RNA with drug-like small molecules , 2018, Nature Reviews Drug Discovery.
[54] J. Lieberman. Tapping the RNA world for therapeutics , 2018, Nature Structural & Molecular Biology.
[55] C. Wahlestedt,et al. Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme , 2018, Molecular cancer.
[56] A. Sood,et al. RNA interference-based therapy and its delivery systems , 2018, Cancer and Metastasis Reviews.
[57] R. Dahiya,et al. MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma , 2018, Molecular Cancer Therapeutics.
[58] Shu-jie Chen,et al. HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells , 2018, Gastric Cancer.
[59] Ye Feng,et al. miR-613 inhibits gastric cancer progression through repressing brain derived neurotrophic factor. , 2018, Experimental and therapeutic medicine.
[60] Xiulan Zhao,et al. Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion , 2018, Molecular Cancer.
[61] Feng Xu,et al. Long non-coding RNA HOTAIR functions as miRNA sponge to promote the epithelial to mesenchymal transition in esophageal cancer. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[62] Seongman Kang,et al. Ataxin-1 regulates epithelial–mesenchymal transition of cervical cancer cells , 2017, Oncotarget.
[63] Jie Zhang,et al. HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway , 2017, Cancer Cell International.
[64] Xiangyi Zheng,et al. miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer , 2016, Cell Death & Disease.
[65] Wolfgang Wagner,et al. The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation , 2016, Nucleic acids research.
[66] Samie R. Jaffrey,et al. m6A RNA methylation promotes XIST-mediated transcriptional repression , 2016, Nature.
[67] A. Tramontano,et al. The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition , 2016, Oncogene.
[68] S. Lakhani,et al. Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer , 2016, Human molecular genetics.
[69] Aaron M. Johnson,et al. An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR , 2016, RNA.
[70] N. Kim,et al. Estradiol, TGF-β1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration. , 2016, Oncology letters.
[71] Yang Liu,et al. MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells , 2016, Journal of Experimental & Clinical Cancer Research.
[72] Claudia Berrondo,et al. Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes , 2016, PloS one.
[73] Jessica L. Childs-Disney,et al. Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells. , 2016, Annual review of pharmacology and toxicology.
[74] Saeed Tavazoie,et al. HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events , 2015, Cell.
[75] C. Brocker,et al. Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. , 2015, Biochimica et biophysica acta.
[76] B. Garcia,et al. A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation. , 2015, Molecular cell.
[77] John T. Powers,et al. The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming , 2014, Stem cell reports.
[78] Yun-fei Yuan,et al. MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis , 2014, Medical Oncology.
[79] F. Gao,et al. Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1. , 2014, Biochimica et biophysica acta.
[80] Xiaojiao Zhang,et al. The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer. , 2014, Carcinogenesis.
[81] Ming Liu,et al. Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma , 2014, Medical Oncology.
[82] S. Zhuang,et al. MicroRNA-148a suppresses the epithelial–mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling , 2014, Oncogene.
[83] Jeannie T. Lee,et al. Regulatory interactions between RNA and polycomb repressive complex 2. , 2014, Molecular cell.
[84] Jian Chen,et al. Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. , 2014, Oncology reports.
[85] M. Weng,et al. Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer , 2014, Molecular Cancer.
[86] A. Marchetti,et al. Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte , 2014, Liver international : official journal of the International Association for the Study of the Liver.
[87] S. Qiu,et al. Molecular and Cellular Pathobiology HNRNPAB Induces Epithelial – Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL , 2014 .
[88] R. Dahiya,et al. Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells* , 2014, The Journal of Biological Chemistry.
[89] F. Sánchez‐Madrid,et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs , 2013, Nature Communications.
[90] J. Rinn,et al. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination , 2013, Nature Communications.
[91] Matheus C. Bürger,et al. Brief Report: The lincRNA Hotair Is Required for Epithelial‐to‐Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines , 2013, Stem cells.
[92] Howard Y. Chang,et al. Targeted disruption of Hotair leads to homeotic transformation and gene derepression. , 2013, Cell reports.
[93] A. Bhan,et al. Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. , 2013, Journal of molecular biology.
[94] T. Cech,et al. Promiscuous RNA binding by Polycomb Repressive Complex 2 , 2013, Nature Structural &Molecular Biology.
[95] Jeffrey T. Chang,et al. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties , 2013, Scientific Reports.
[96] Rajvir Dahiya,et al. Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR , 2013, PloS one.
[97] Xu Li,et al. microRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition , 2013, Tumor Biology.
[98] Wanjun Yu,et al. MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells , 2013, Molecular and Cellular Biochemistry.
[99] Erik K Flemington,et al. Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen , 2013, Journal of Hematology & Oncology.
[100] C. Gong,et al. Long non‐coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival , 2013, Cancer science.
[101] R. Micura,et al. Long non-coding RNAs as targets for cytosine methylation , 2013, RNA biology.
[102] Samy Lamouille,et al. TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression , 2013, Current opinion in oncology.
[103] Gianluca Gregori,et al. Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer , 2012, Breast Cancer Research and Treatment.
[104] J. Thiery,et al. Runx3 Protects Gastric Epithelial Cells Against Epithelial‐Mesenchymal Transition‐Induced Cellular Plasticity and Tumorigenicity , 2012, Stem cells.
[105] A. Munkarah,et al. Metformin: An Emerging New Therapeutic Option for Targeting Cancer Stem Cells and Metastasis , 2012, Journal of oncology.
[106] S. Safe,et al. HOTAIR IS A NEGATIVE PROGNOSTIC FACTOR AND EXHIBITS PRO-ONCOGENIC ACTIVITY IN PANCREATIC CANCER , 2012, Oncogene.
[107] M. Toyota,et al. Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. , 2012, Cancer research.
[108] T. Preiss,et al. Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA , 2012, Nucleic acids research.
[109] Junfeng Zhang,et al. miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1. , 2012, Biochemical and biophysical research communications.
[110] F. Gonzalez,et al. Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice* , 2012, The Journal of Biological Chemistry.
[111] A. Marchetti,et al. An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs , 2011, Cell Death and Differentiation.
[112] Q. Li,et al. Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression , 2011, The Journal of international medical research.
[113] Christopher A. Maher,et al. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition , 2011, The Journal of cell biology.
[114] A. Marchetti,et al. The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α , 2011, Hepatology.
[115] A. Feinberg,et al. Genome-scale epigenetic reprogramming during epithelial to mesenchymal transition , 2011, Nature Structural &Molecular Biology.
[116] Howard Y. Chang,et al. Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes , 2010, Science.
[117] Howard Y. Chang,et al. Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis , 2010, Nature.
[118] M. F. Shannon,et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. , 2008, Cancer research.
[119] G. Goodall,et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.
[120] Sun-Mi Park,et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. , 2008, Genes & development.
[121] Howard Y. Chang,et al. Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs , 2007, Cell.
[122] Héctor Peinado,et al. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? , 2007, Nature Reviews Cancer.
[123] Janghoo Lim,et al. ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology , 2006, Cell.
[124] G. Konopka,et al. Hepatocyte nuclear factor 4 (cid:1) orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver , 2006 .
[125] K. Kaestner,et al. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. , 2006, Gastroenterology.
[126] Yang Shi,et al. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.
[127] S. Ramaswamy,et al. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.
[128] Peter A. Jones,et al. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[129] J. Adamson,et al. Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis , 2003, Nature Genetics.
[130] M. Nieto,et al. The snail superfamily of zinc-finger transcription factors , 2002, Nature Reviews Molecular Cell Biology.
[131] G. Stamp,et al. Validation of a model of colon cancer progression , 2000, The Journal of pathology.
[132] G. Kidd,et al. Mutational Analysis of a Heterogeneous Nuclear Ribonucleoprotein A2 Response Element for RNA Trafficking* , 1999, The Journal of Biological Chemistry.
[133] A. Krainer,et al. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. , 1994, The EMBO journal.
[134] Xiaogang Yang,et al. IncRNA TYMSOS Promotes Epithelial-Mesenchymal Transition and Metastasis in Thyroid Carcinoma through Regulating MARCKSL1 and Activating the PI3K/Akt Signaling Pathway. , 2022, Critical reviews in eukaryotic gene expression.
[135] C. Steindler,et al. TGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: implication for hepatocellular carcinoma gene therapy. , 2013, Journal of hepatology.
[136] C. Steindler,et al. TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling. , 2008, Experimental cell research.
[137] F. Spagnoli,et al. Snail controls differentiation of hepatocytes by repressing HNF4alpha expression. , 2006, Journal of cellular physiology.