论文信息 - The First Example of an Intramolecular Diels—Alder Furan (IMDAF) Reaction of Iminium Salts and Its Application in a Short and Simple Synthesis of the Isoindolo[1,2-a]isoquinoline Core of the Jamtine and Hirsutine Alkaloids.

The First Example of an Intramolecular Diels—Alder Furan (IMDAF) Reaction of Iminium Salts and Its Application in a Short and Simple Synthesis of the Isoindolo[1,2-a]isoquinoline Core of the Jamtine and Hirsutine Alkaloids.

N-Alkylation of isoquinoline derivatives with alkyl halides affords intermediate iminium salts, which undergo unexpected spontaneous intramolecular Diels—Alder reaction to produce cycloadducts with the basic structural core of the title alkaloids.

[1] A. V. Varlamov,et al. The first example of an intramolecular Diels-Alder furan (IMDAF) reaction of iminium salts and its application in a short and simple synthesis of the isoindolo(1,2-a)isoquinoline core of the jamtine and hirsutine alkaloids , 2010 .