Planar 2D-Array Neural Probe for Deep Brain Stimulation and Recording (DBSR)

Implantable micromachined probes with planar electrode arrays for neural stimulation and recording were designed, fabricated and evaluated. Probes have been realized with distributed electrode sites and different electrode configurations (i.e. size and geometry). These were tested for their ability to selectively record and stimulate cortical brain areas. The probes were stereotactically implanted into the cortical region of the rat brains without breaking and were successfully used to measure neural signals and evoke limb contraction in response to electrical stimulation.

[1]  A. Benabid,et al.  Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. , 1987, Applied neurophysiology.

[2]  U. Hofmann,et al.  Institute of Physics Publishing Journal of Micromechanics and Microengineering a 32-site Neural Recording Probe Fabricated by Drie of Soi Substrates , 2022 .

[3]  T. Blanche,et al.  Polytrodes: high-density silicon electrode arrays for large-scale multiunit recording. , 2005, Journal of neurophysiology.

[4]  R. Normann,et al.  Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex , 1998, Journal of Neuroscience Methods.

[5]  O. Paul,et al.  Microprobe Array with Low Impedance Electrodes and Highly Flexible Polyimide Cables for Acute Neural Recording , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[6]  A. Destée,et al.  Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. , 2005, The New England journal of medicine.

[7]  A. Lozano,et al.  Deep Brain Stimulation for Treatment-Resistant Depression , 2005, Neuron.

[8]  Ueli Rutishauser,et al.  Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo , 2006, Journal of Neuroscience Methods.

[9]  Mojgan Hodaie,et al.  Chronic Anterior Thalamus Stimulation for Intractable Epilepsy , 2002, Epilepsia.

[10]  J. Gybels,et al.  Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder , 1999, The Lancet.

[11]  Masatoshi Nakamura,et al.  Parametric modeling of somatosensory evoked potentials using discrete cosine transform , 2001, IEEE Transactions on Biomedical Engineering.

[12]  E. Schmidt,et al.  Long-term implants of Parylene-C coated microelectrodes , 2006, Medical and Biological Engineering and Computing.

[13]  J. Csicsvari,et al.  Massively parallel recording of unit and local field potentials with silicon-based electrodes. , 2003, Journal of neurophysiology.

[14]  Jack W. Judy,et al.  Multielectrode microprobes for deep-brain stimulation fabricated with a customizable 3-D electroplating process , 2005, IEEE Transactions on Biomedical Engineering.

[15]  A. Benabid,et al.  Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. , 1996, Journal of neurosurgery.

[16]  D. A. Ksienski,et al.  A minimum profile uniform current density electrode , 1992, IEEE Transactions on Biomedical Engineering.

[17]  K. Wise,et al.  A multichannel neural probe for selective chemical delivery at the cellular level , 1997, IEEE Transactions on Biomedical Engineering.

[18]  A. Benabid.  Deep brain stimulation for Parkinson’s disease , 2003, Current Opinion in Neurobiology.

[19]  R. Olsson,et al.  A three-dimensional neural recording microsystem with implantable data compression circuitry , 2005, ISSCC. 2005 IEEE International Digest of Technical Papers. Solid-State Circuits Conference, 2005..

[20]  K.D. Wise,et al.  Microassembly Techniques for a Three-Dimensional Neural Stimulating Microelectrode Array , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[21]  Qing Bai,et al.  Single-unit neural recording with active microelectrode arrays , 2001, IEEE Transactions on Biomedical Engineering.

[22]  Justin C. Williams,et al.  Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex , 2004, IEEE Transactions on Biomedical Engineering.