TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

[1]  V. Arlt,et al.  Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. , 2014, Toxicology.

[2]  X. Castells,et al.  Modelling mutational landscapes of human cancers in vitro , 2014, Scientific Reports.

[3]  V. Arlt,et al.  ³²P-postlabeling analysis of DNA adducts. , 2014, Methods in molecular biology.

[4]  O. Schärer.  Nucleotide excision repair in eukaryotes. , 2013, Cold Spring Harbor perspectives in biology.

[5]  V. Arlt,et al.  ³²P-postlabeling analysis of DNA adducts. , 2013, Methods in molecular biology.

[6]  J. Kleinjans,et al.  Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: Toxicokinetics is essential for in vivo–in vitro comparisons , 2012, Archives of Toxicology.

[7]  V. Arlt,et al.  Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling. , 2012, Toxicology letters.

[8]  A. Schetter,et al.  Tumor suppressor p53 (TP53) at the crossroads of the exposome and the cancer genome , 2012, Proceedings of the National Academy of Sciences.

[9]  R. Godschalk,et al.  Abstract 4118: Hypoxia affects the metabolic activation and detoxification of the environmental mutagen benzo(a)pyrene , 2012 .

[10]  M. Hollstein,et al.  Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock‐in (Hupki) mouse genome , 2010, Molecular carcinogenesis.

[11]  G. Pfeifer,et al.  Applications of the human p53 knock‐in (Hupki) mouse model for human carcinogen testing , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  J. Kucab,et al.  Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock‐in (Hupki) mouse model , 2010, The FEBS journal.

[13]  Magali Olivier,et al.  TP53 mutations in human cancers: origins, consequences, and clinical use. , 2010, Cold Spring Harbor perspectives in biology.

[14]  M. Hollstein,et al.  TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy‐associated tumours , 2009, International journal of cancer.

[15]  M. Hollstein,et al.  The carcinogenic air pollutant 3-nitrobenzanthrone induces GC to TA transversion mutations in human p53 sequences. , 2008, Mutagenesis.

[16]  J. Hoeijmakers,et al.  Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts. , 2008, DNA repair.

[17]  D. Segerbäck,et al.  Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide. , 2008, DNA repair.

[18]  Eduardo Sontag,et al.  Transcriptional control of human p53-regulated genes , 2008, Nature Reviews Molecular Cell Biology.

[19]  M. Hollstein,et al.  Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72. , 2007, Oncogene.

[20]  V. Arlt,et al.  Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo : experiments with Hepatic Cytochrome P450 Reductase Null mice , 2008 .

[21]  I. Giddings,et al.  Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. , 2008, Carcinogenesis.

[22]  M. Olivier,et al.  Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database , 2007, Human mutation.

[23]  D. Patel,et al.  Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context , 2007, Nucleic acids research.

[24]  M. Hollstein,et al.  Mutagenesis of human p53 tumor suppressor gene sequences in embryonic fibroblasts of genetically-engineered mice. , 2007, Genetic engineering.

[25]  M. Hollstein,et al.  Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences. , 2006, Mutation research.

[26]  Y. A. Wang,et al.  The Involvement of Ataxia-telangiectasia Mutated Protein Activation in Nucleotide Excision Repair-facilitated Cell Survival with Cisplatin Treatment* , 2006, Journal of Biological Chemistry.

[27]  M. Csete,et al.  Oxygen in the Cultivation of Stem Cells , 2005, Annals of the New York Academy of Sciences.

[28]  M. Hollstein,et al.  p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. , 2005, Cancer research.

[29]  A. Seidel,et al.  Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells. , 2005, Chemical research in toxicology.

[30]  H. Naegeli,et al.  Mechanisms of repair of polycyclic aromatic hydrocarbon-induced DNA damage , 2005 .

[31]  V. Arlt,et al.  32P-postlabeling analysis of DNA adducts. , 2005, Methods in molecular biology.

[32]  M. Hollstein,et al.  Murine Fibroblasts Correlate with p 53 Mutations in Human Lung Tumors , 2005 .

[33]  D. Lane,et al.  Transcription — guarding the genome by sensing DNA damage , 2004, Nature Reviews Cancer.

[34]  M. Hollstein,et al.  Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  P. Hornsby.  Mouse and human cells versus oxygen. , 2003, Science of aging knowledge environment : SAGE KE.

[36]  S. Kato,et al.  Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[37]  S. Melov,et al.  Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts , 2003, Nature Cell Biology.

[38]  P. Hainaut,et al.  On the origin of G --> T transversions in lung cancer. , 2003, Mutation research.

[39]  F. Cassee,et al.  Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice. , 2003, Carcinogenesis.

[40]  Y. Shinkai,et al.  Polκ protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[42]  Yiwei Li,et al.  Molecular analysis of p53 and K-ras in lung carcinomas of coal miners. , 2001, International journal of molecular medicine.

[43]  E. Friedberg.  How nucleotide excision repair protects against cancer , 2001, Nature Reviews Cancer.

[44]  M. Olivier,et al.  Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions. , 2001, Cancer research.

[45]  K. Tanaka,et al.  UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency. , 2001, Mutation research.

[46]  H. van Steeg,et al.  Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice. , 2001, Carcinogenesis.

[47]  F. Gruijl,et al.  Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity. , 2001, Cancer research.

[48]  M. Hollstein,et al.  Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool , 2001, Oncogene.

[49]  H. van Steeg,et al.  DNA Repair—Deficient Xpa and Xpa/p53+/- Knock-Out Mice: Nature of the Models , 2001, Toxicologic pathology.

[50]  G. Pfeifer.  p53 mutational spectra and the role of methylated CpG sequences. , 2000, Mutation research.

[51]  K. Imaida,et al.  Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP). , 2000, Cancer letters.

[52]  P. Hanawalt,et al.  p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells. , 2000, Cancer research.

[53]  M. Hollstein,et al.  p53 and human cancer: the first ten thousand mutations. , 2000, Advances in cancer research.

[54]  D. Jerina,et al.  Characterization of the mutational profile of (+)-7R,8S-dihydroxy-9S, 10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphoribosyltransferase gene in repair-deficient Chinese hamster V-H1 cells. , 1999, Carcinogenesis.

[55]  L. Mullenders,et al.  Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema. , 1998, The Journal of investigative dermatology.

[56]  M. Tang,et al.  Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers , 1998, Oncogene.

[57]  E. Kroese,et al.  Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development. , 1997, Carcinogenesis.

[58]  M. Tang,et al.  Cytosine methylation determines hot spots of DNA damage in the human P53 gene. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[59]  H. van Steeg,et al.  Relative susceptibilities of XPA knockout mice and their heterozygous and wild-type littermates to UVB-induced skin cancer. , 1997, Cancer research.

[60]  M. Tang,et al.  Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 , 1996, Science.

[61]  M. Ljungman,et al.  Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis. , 1996, Oncogene.

[62]  F. Gruijl,et al.  Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA , 1995, Nature.

[63]  M. Denissenko,et al.  DNA repair in human cells: quantitative assessment of bulky anti-BPDE-DNA adducts by non-competitive immunoassays. , 1995, Carcinogenesis.

[64]  Q. He,et al.  Selective recognition of the m5CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking. , 1995, Bioorganic & medicinal chemistry.

[65]  W. T. Adams,et al.  Computer program for the analysis of mutational spectra: application to p53 mutations. , 1994, Carcinogenesis.

[66]  P. Hanawalt,et al.  Preferential repair of ultraviolet light‐induced dna damage in the transcribed strand of the human p53 gene , 1994, Molecular carcinogenesis.

[67]  K. Kilgore,et al.  Development of an in vitro primary screen for skin depigmentation and antimelanoma agents. , 1994, Skin pharmacology : the official journal of the Skin Pharmacology Society.

[68]  E. Loechler,et al.  Mutational specificity of the (+)-anti-diol epoxide of benzo[a]pyrene in a supF gene of an Escherichia coli plasmid: DNA sequence context influences hotspots, mutagenic specificity and the extent of SOS enhancement of mutagenesis. , 1993, Carcinogenesis.

[69]  T. Goodrow,et al.  Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[70]  D. Lane,et al.  p53, guardian of the genome , 1992, Nature.

[71]  D. Lane,et al.  Cancer. p53, guardian of the genome. , 1992, Nature.

[72]  B. Vogelstein,et al.  p53 mutations in human cancers. , 1991, Science.

[73]  J. Mccormick,et al.  Lack of a Cell Cycle-dependent Strand Bias for Mutations Induced in the HPRT Gene by (±)-7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in Excision Repair-deficient Human Cells , 1991 .

[74]  J. Mccormick,et al.  Lack of a cell cycle-dependent strand bias for mutations induced in the HPRT gene by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in excision repair-deficient human cells. , 1991, Cancer Research.

[75]  N. Geacintov,et al.  Base-sequence dependence of noncovalent complex formation and reactivity of benzo[a]pyrene diol epoxide with polynucleotides. , 1988, Biochemistry.

[76]  B. Shaw,et al.  Base stacking and molecular polarizability: effect of a methyl group in the 5-position of pyrimidines. , 1987, Biochemical and biophysical research communications.

[77]  Adams Wt,et al.  Statistical test for the comparison of samples from mutational spectra , 1987 .

[78]  T R Skopek,et al.  Statistical test for the comparison of samples from mutational spectra. , 1987, Journal of molecular biology.

[79]  K. Brookman,et al.  Hypersensitivity to cell killing and mutation induction by chemical carcinogens in an excision repair-deficient mutant of CHO cells. , 1983, Mutation research.

[80]  J. Miller,et al.  Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[81]  P. Fu,et al.  SYNTHESIS AND REACTIONS OF DIOL EPOXIDES AND RELATED METABOLITES OF CARCINOGENIC HYDROCARBONS , 1980 .

[82]  P. Fu,et al.  6 – Synthesis and Reactions of Diol Epoxides and Related Metabolites of Carcinogenic Hydrocarbons , 1978 .

[83]  B. Ames,et al.  Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. , 1975, Mutation research.