Polarimetric imaging and blood vessel quantification.

We applied a polarimetric analysis to retinal imaging, to examine the potential improvement in characterizing blood vessels. To minimize the reflection artifact of the superficial wall of the blood vessel, we computed depolarized light images by removing the polarization retaining light reaching the instrument. These depolarized light images were compared to images from the average of all the light. Michelson contrast was computed for the vessel profiles across arteries and veins, and was higher for the depolarized light images. Depolarized light images provide one step towards improving the characterization of retinal blood vessels.

[1]  A. Dreher,et al.  Differentiating patients with glaucoma from glaucoma suspects and normal subjects by nerve fiber layer assessment with scanning laser polarimetry. , 1998, Ophthalmology.

[2]  M. H. Smith,et al.  Effect of multiple light paths on retinal vessel oximetry. , 2000, Applied optics.

[3]  A. Bharath,et al.  Computer algorithms for the automated measurement of retinal arteriolar diameters , 2001, The British journal of ophthalmology.

[4]  R. Klein,et al.  The relation of retinal microvascular characteristics to age-related eye disease: the Beaver Dam eye study. , 2004, American journal of ophthalmology.

[5]  Ann E Elsner,et al.  Improved contrast of subretinal structures using polarization analysis. , 2003, Investigative ophthalmology & visual science.

[6]  Art Lompado,et al.  Retinal venous oxygen saturation and cardiac output during controlled hemorrhage and resuscitation. , 2003, Journal of applied physiology.

[7]  Robert N Weinreb,et al.  Correction for corneal polarization axis improves the discriminating power of scanning laser polarimetry. , 2002, American journal of ophthalmology.

[8]  B. Boycott,et al.  Organization of the Primate Retina: Light Microscopy , 1969 .

[9]  Ann E. Elsner,et al.  Three dimensional imaging in age-related macular degeneration. , 2001, Optics express.

[10]  Stephen A. Burns,et al.  Infrared imaging of sub-retinal structures in the human ocular fundus , 1996, Vision Research.

[11]  Juan M Bueno,et al.  Confocal scanning laser ophthalmoscopy improvement by use of Mueller-matrix polarimetry. , 2002, Optics letters.

[12]  Susana Marcos,et al.  Contrast improvement of confocal retinal imaging by use of phase-correcting plates. , 2002, Optics letters.

[13]  A. Elsner,et al.  Birefringence of intraocular lenses , 2003, Journal of cataract and refractive surgery.

[14]  Juan M. Bueno,et al.  Polarimetry in the human eye using an imaging linear polariscope , 2002 .