Trisomy 3 in two paediatric post‐transplant lymphomas

Summary. Few cytogenetic data are available concerning the chromosomal constitution of post‐transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post‐transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence in situ hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non‐Hodgkin's lymphomas but it is relatively rare in B‐cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease.

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