Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis

[1]  B. Joe,et al.  Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats , 2023, Gut microbes.

[2]  Henry C. Lin,et al.  Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway , 2022, Frontiers in Cellular and Infection Microbiology.

[3]  Haoming Zhou,et al.  XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury , 2022, Redox biology.

[4]  E. Savarino,et al.  A specific microbiota signature is associated to various degrees of ulcerative colitis as assessed by a machine learning approach , 2022, Gut microbes.

[5]  D. Rubin,et al.  WHAT DOES DISEASE PROGRESSION LOOK LIKE IN ULCERATIVE COLITIS AND HOW MIGHT IT BE PREVENTED? , 2022, Gastroenterology.

[6]  T. Borody,et al.  Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial. , 2021, The lancet. Gastroenterology & hepatology.

[7]  G. Hartmann,et al.  Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus , 2021, Journal of clinical immunology.

[8]  Daisuke Watanabe,et al.  Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease , 2021, EMBO molecular medicine.

[9]  J. Lieberman,et al.  NLRP3 inflammasome activation triggers gasdermin D–independent inflammation , 2021, Science Immunology.

[10]  Rui Zhang,et al.  Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. , 2021, Journal of medicinal chemistry.

[11]  S. Mondot,et al.  Dynamic properties of the intestinal ecosystem call for combination therapies, targeting inflammation and microbiota, in ulcerative colitis. , 2021, Gastroenterology.

[12]  Henry C. Lin,et al.  Notch Signaling Pathway Is Activated by Sulfate Reducing Bacteria , 2021, Frontiers in Cellular and Infection Microbiology.

[13]  H. Tilg,et al.  Calprotectin: from biomarker to biological function , 2021, Gut.

[14]  B. Tang,et al.  Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration , 2021, Microbiome.

[15]  Yu-Wei Chang,et al.  Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages , 2021, Life.

[16]  Hua Zhu,et al.  Gasdermin D in pyroptosis , 2021, Acta pharmaceutica Sinica. B.

[17]  Lihong Hu,et al.  Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation , 2021, Acta pharmaceutica Sinica. B.

[18]  S. Kondo,et al.  Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk. , 2021, Bioscience, biotechnology, and biochemistry.

[19]  Biqing Chen,et al.  Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics , 2021, Gut microbes.

[20]  W. Jia,et al.  Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice , 2021, Gut microbes.

[21]  C. Bryant,et al.  Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages , 2020, The Journal of Immunology.

[22]  A. Griffiths,et al.  STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD. , 2020, Gastroenterology.

[23]  T. Hibi,et al.  Ulcerative colitis , 2020, Nature Reviews Disease Primers.

[24]  Kailiang Zhou,et al.  Role of pyroptosis in spinal cord injury and its therapeutic implications , 2020, Journal of advanced research.

[25]  G. Rogler,et al.  Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission. , 2020, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[26]  Si Ming Man,et al.  Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer , 2020, Immunological reviews.

[27]  G. Dubyak,et al.  Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis. , 2020, The Journal of clinical investigation.

[28]  I. Rauch,et al.  The NAIP/NLRC4 inflammasome in infection and pathology. , 2020, Molecular aspects of medicine.

[29]  K. Lassen,et al.  Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation , 2020, Science Advances.

[30]  Zhixing He,et al.  Early and Short-Term Interventions in the Gut Microbiota Affects Lupus Severity, Progression, and Treatment in MRL/lpr Mice , 2020, Frontiers in Microbiology.

[31]  D. Dordević,et al.  Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development , 2020, Journal of advanced research.

[32]  R. Ley,et al.  Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases , 2019, Nature Communications.

[33]  F. Shao,et al.  The gasdermins, a protein family executing cell death and inflammation , 2019, Nature Reviews Immunology.

[34]  Yu-Wei Chang,et al.  Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus , 2019, International journal of molecular sciences.

[35]  Yinan Wei,et al.  Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. , 2019, Immunity.

[36]  A. Griffiths,et al.  Clinical value of fecal calprotectin , 2019, Critical reviews in clinical laboratory sciences.

[37]  J. Ting,et al.  The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.

[38]  Honggang Zhou,et al.  Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction , 2018, EBioMedicine.

[39]  Si Ming Man.  Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis , 2018, Nature Reviews Gastroenterology & Hepatology.

[40]  T. Savidge,et al.  Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life , 2018, Cellular and molecular gastroenterology and hepatology.

[41]  V. Tešević,et al.  Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. , 2018, Journal of ethnopharmacology.

[42]  J. Duncan,et al.  The NLRC4 Inflammasome , 2018, Immunological reviews.

[43]  R. Coutinho-Silva,et al.  Sulfate‐reducing bacteria stimulate gut immune responses and contribute to inflammation in experimental colitis , 2017, Life sciences.

[44]  R. Flavell,et al.  Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation. , 2017, Cell reports.

[45]  I. Brodsky,et al.  NAIP‐NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL‐18 Release via Activation of Caspase‐1 and ‐8 , 2017, Immunity.

[46]  S. Shen-Orr,et al.  Social network architecture of human immune cells unveiled by quantitative proteomics , 2017, Nature Immunology.

[47]  Chien-Sung Tsai,et al.  Thrombomodulin regulates monocye differentiation via PKCδ and ERK1/2 pathway in vitro and in atherosclerotic artery , 2016, Scientific Reports.

[48]  Y. Sugiyama,et al.  Plant-Derived Polyphenols Interact with Staphylococcal Enterotoxin A and Inhibit Toxin Activity , 2016, PloS one.

[49]  T. Cai,et al.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death , 2015, Nature.

[50]  R. Vance.  The NAIP/NLRC4 inflammasomes. , 2015, Current opinion in immunology.

[51]  M. Totsuka,et al.  Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice. , 2015, Food chemistry.

[52]  K. Sheahan,et al.  Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis , 2014, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[53]  Y. Naito,et al.  Role of metallothionein in murine experimental colitis. , 2013, International journal of molecular medicine.

[54]  Sanjai J. Parikh,et al.  Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut , 2013, Science.

[55]  Hao Xu,et al.  The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus , 2011, Nature.

[56]  Fatih Ozsolak,et al.  RNA sequencing: advances, challenges and opportunities , 2011, Nature Reviews Genetics.

[57]  J. Coffey,et al.  Desulfovibrio Bacterial Species Are Increased in Ulcerative Colitis , 2010, Diseases of the colon and rectum.

[58]  J. Orenstein,et al.  Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research , 2007, Nature Protocols.

[59]  M. Katoh,et al.  Identification and characterization of human CXXC10 gene in silico. , 2004, International journal of oncology.