Synthesis and Characterization of Silicon-Doped Hydroxyapatite

Silicon was doped to hydroxyapatite by hydrothermal techniques for higher biocompatibility. Products contained tetra-ethyl-orthosilicate (TEOS) as a silicon source in the range of 0 to 15 mass%. In order to evaluate bioactivity of silicon-doped hydroxyapatite, the samples were soaked in simulated body fluid (SBF). Silicon doped samples showed faster apatite forming ability than the undoped samples. The samples were examined by transmission electron microscopy (TEM), X-ray diffraction patterns (XRD), Fourier transform infrared spectroscopy (FTIR) and X-ray absorption fine structure (XAFS). There results indicated that SiO4 4� ion substituted PO4 3� ion site in apatite structures. And it was found that appropriate TEOS doping ratio was 10 mass% for superior biocompatibility due to amorphous SiO2 segregation in the 15 mass% TEOS doped samples. [doi:10.2320/matertrans.MC200808]

[1]  J. G. López,et al.  Study of the composition transfer in the pulsed laser deposition of silicon substituted hydroxyapatite thin films , 2007 .

[2]  Jooho Moon,et al.  Preparation of porous Si-incorporated hydroxyapatite , 2005 .

[3]  M. Dunn,et al.  Effect of Ca/P coating resorption and surgical fit on the bone/implant interface. , 1994, Journal of biomedical materials research.

[4]  A. Nakahira,et al.  EVALUATION OF CADMIUM REMOVAL IN SOLUTION USING VARIOUS HYDROXYAPATITES AND CATTLE BONE , 2004 .

[5]  G. Logroscino,et al.  Physico-chemical properties and solubility behaviour of multi-substituted hydroxyapatite powders containing silicon , 2008 .

[6]  A. Nakahira,et al.  Synthesis of Modified Hydroxyapatite (HAP) Substituted With Fe Ion for DDS Application , 2007, IEEE Transactions on Magnetics.

[7]  T. Kokubo.  Surface chemistry of bioactive glass-ceramics , 1990 .

[8]  E M Carlisle,et al.  Silicon: A Possible Factor in Bone Calcification , 1970, Science.

[9]  P Ducheyne,et al.  Bioactive glass particulate material as a filler for bone lesions. , 2008, Journal of oral rehabilitation.

[10]  I. Rehman,et al.  Characterization of hydroxyapatite and carbonated apatite by photo acoustic FTIR spectroscopy , 1997, Journal of materials science. Materials in medicine.

[11]  V. Perdikatsis,et al.  Neutron powder diffraction studies of silicon-substituted hydroxyapatite. , 2003, Biomaterials.

[12]  J. Lacout,et al.  Synthesis of phosphate-silicate apatites at atmospheric pressure , 1997 .

[13]  H. Doggett.  Disruptive Selection in Crop Development , 1965, Nature.